Cytotoxic activity of Secondary Metabolites from Marine-derived FungusNeosartorya siamensisin Human Cancer Cells

2016 ◽  
Vol 30 (11) ◽  
pp. 1862-1871 ◽  
Author(s):  
M. Prata-Sena ◽  
A.A. Ramos ◽  
S. Buttachon ◽  
B. Castro-Carvalho ◽  
P. Marques ◽  
...  
Keyword(s):  
Secondary Metabolites ◽  
Cytotoxic Activity ◽  
Cancer Cells ◽  
Human Cancer ◽  
Human Cancer Cells

Glaziovianin A, a New Isoflavone, from the Leaves of Ateleia Glaziovianna and Its Cytotoxic Activity Against Human Cancer Cells.

ChemInform ◽  
2007 ◽  
Vol 38 (41) ◽  
Author(s):  
Akihito Yokosuka ◽  
Mitsue Haraguchi ◽  
Takeo Usui ◽  
Sayaka Kazami ◽  
Hiroyuki Osada ◽  
...  
Keyword(s):  
Cytotoxic Activity ◽  
Cancer Cells ◽  
Human Cancer ◽  
Human Cancer Cells

scholarly journals Maytenus disticha Extract and an Isolated β-Dihydroagarofuran Induce Mitochondrial Depolarization and Apoptosis in Human Cancer Cells by Increasing Mitochondrial Reactive Oxygen Species

Biomolecules ◽  
2020 ◽  
Vol 10 (3) ◽  
pp. 377
Author(s):  
Iván González-Chavarría ◽  
Felix Duprat ◽  
Francisco J. Roa ◽  
Nery Jara ◽  
Jorge R. Toledo ◽  
...  
Keyword(s):  
Cytotoxic Activity ◽  
Cancer Cells ◽  
Human Cancer ◽  
Ros Generation ◽  
Active Components ◽  
Total Extract ◽  
Human Cancer Cells ◽  
Mitochondrial Superoxide ◽  
Mitochondrial Membrane Depolarization ◽  
Mcf 7

Maytenus disticha (Hook F.), belonging to the Celastraceae family, is an evergreen shrub, native of the central southern mountains of Chile. Previous studies demonstrated that the total extract of M. disticha (MD) has an acetylcholinesterase inhibitory activity along with growth regulatory and insecticidal activities. β-Dihydroagarofurans sesquiterpenes are the most active components in the plant. However, its activity in cancer has not been analyzed yet. Here, we demonstrate that MD has a cytotoxic activity on breast (MCF-7), lung (PC9), and prostate (C4-2B) human cancer cells with an IC50 (µg/mL) of 40, 4.7, and 5 µg/mL, respectively, an increasing Bax/Bcl2 ratio, and inducing a mitochondrial membrane depolarization. The β-dihydroagarofuran-type sesquiterpene (MD-6), dihydromyricetin (MD-9), and dihydromyricetin-3-O-β-glucoside (MD-10) were isolated as the major compounds from MD extracts. From these compounds, only MD-6 showed cytotoxic activity on MCF-7, PC9, and C4-2B with an IC50 of 31.02, 17.58, and 42.19 µM, respectively. Furthermore, the MD-6 increases cell ROS generation, and MD and MD-6 induce a mitochondrial superoxide generation and apoptosis on MCF-7, PC9, and C4-2B, which suggests that the cytotoxic effect of MD is mediated in part by the β-dihydroagarofuran-type that induces apoptosis by a mitochondrial dysfunction.

scholarly journals Synthesis of cucurbitacin IIa derivatives with apoptosis-inducing capabilities in human cancer cells

RSC Advances ◽  
2020 ◽  
Vol 10 (7) ◽  
pp. 3872-3881
Author(s):  
Kun Yu ◽  
Xinmei Yang ◽  
Ying Li ◽  
Xue Cui ◽  
Bo Liu ◽  
...  
Keyword(s):  
Cytotoxic Activity ◽  
Cancer Cells ◽  
Human Cancer ◽  
Human Cancer Cells

Twenty-one cucurbitacin IIa derivatives were synthesized and screened for cytotoxic activity.

Phenylarsonic Acid Compounds with Broad-Spectrum and Potent Cytotoxic Activity against Human Cancer Cells

2011 ◽  
Vol 53 (06) ◽  
pp. 428-439
Author(s):  
Fatih Uckun ◽  
Osmond D’Cruz ◽  
Xing-Ping Liu ◽  
Rama Narla
Keyword(s):  
Cytotoxic Activity ◽  
Cancer Cells ◽  
Broad Spectrum ◽  
Human Cancer ◽  
Human Cancer Cells ◽  
Phenylarsonic Acid

scholarly journals Momordica charantiaExtract Induces Apoptosis in Human Cancer Cells through Caspase- and Mitochondria-Dependent Pathways

2012 ◽  
Vol 2012 ◽  
pp. 1-11 ◽  
Author(s):  
Chia-Jung Li ◽  
Shih-Fang Tsang ◽  
Chun-Hao Tsai ◽  
Hsin-Yi Tsai ◽  
Jong-Ho Chyuan ◽  
...  
Keyword(s):  
Cell Death ◽  
Cytotoxic Activity ◽  
Cancer Cells ◽  
Dna Fragmentation ◽  
Human Cancer ◽  
Momordica Charantia ◽  
Carcinoma Cells ◽  
Human Cancer Cells ◽  
Adenocarcinoma Cells ◽  
Anti Cancer

Plants are an invaluable source of potential new anti-cancer drugs.Momordica charantiais one of these plants with both edible and medical value and reported to exhibit anticancer activity. To explore the potential effectiveness ofMomordica charantia, methanol extract ofMomordica charantia(MCME) was used to evaluate the cytotoxic activity on four human cancer cell lines, Hone-1 nasopharyngeal carcinoma cells, AGS gastric adenocarcinoma cells, HCT-116 colorectal carcinoma cells, and CL1-0 lung adenocarcinoma cells, in this study. MCME showed cytotoxic activity towards all cancer cells tested, with the approximate IC50ranging from 0.25 to 0.35 mg/mL at 24 h. MCME induced cell death was found to be time-dependent in these cells. Apoptosis was demonstrated by DAPI staining and DNA fragmentation analysis using agarose gel electrophoresis. MCME activated caspase-3 and enhanced the cleavage of downstream DFF45 and PARP, subsequently leading to DNA fragmentation and nuclear condensation. The apoptogenic protein, Bax, was increased, whereas Bcl-2 was decreased after treating for 24 h in all cancer cells, indicating the involvement of mitochondrial pathway in MCME-induced cell death. These findings indicate that MCME has cytotoxic effects on human cancer cells and exhibits promising anti-cancer activity by triggering apoptosis through the regulation of caspases and mitochondria.

scholarly journals Synthesis and Cytotoxic Activity on Human Cancer Cells of Novel Isoquinolinequinone–Amino Acid Derivatives

Molecules ◽  
2016 ◽  
Vol 21 (9) ◽  
pp. 1199 ◽  
Author(s):  
Jaime Valderrama ◽  
Virginia Delgado ◽  
Sandra Sepúlveda ◽  
Julio Benites ◽  
Cristina Theoduloz ◽  
...  
Keyword(s):  
Amino Acid ◽  
Cytotoxic Activity ◽  
Cancer Cells ◽  
Human Cancer ◽  
Amino Acid Derivatives ◽  
Human Cancer Cells

scholarly journals Cytotoxic activity of Shp2 inhibitor fumosorinone in human cancer cells

2018 ◽  
Author(s):  
Chuan Chen ◽  
Tongdan Xue ◽  
Peng Fan ◽  
Linlin Meng ◽  
Jingjing Wei ◽  
...  
Keyword(s):  
Cytotoxic Activity ◽  
Cancer Cells ◽  
Human Cancer ◽  
Human Cancer Cells

Cytotoxic activity of 9,10-dihydro-2,5-dimethoxyphenanthrene-1,7-diol from Eulophia nuda against human cancer cells

2010 ◽  
Vol 128 (1) ◽  
pp. 251-253 ◽  
Author(s):  
Varsha Shriram ◽  
Vinay Kumar ◽  
P.B. Kavi Kishor ◽  
Sharad B. Suryawanshi ◽  
Ankur K. Upadhyay ◽  
...  
Keyword(s):  
Cytotoxic Activity ◽  
Cancer Cells ◽  
Human Cancer ◽  
Human Cancer Cells

Sesquiterpene lactones from Carpesium rosulatum with potential cytotoxicity against five human cancer cell lines

2010 ◽  
Vol 30 (8) ◽  
pp. 1083-1087 ◽  
Author(s):  
Hyung-In Moon ◽  
Okpyo Zee
Keyword(s):  
Cytotoxic Activity ◽  
Cancer Cells ◽  
Sesquiterpene Lactone ◽  
Cell Lines ◽  
Human Cancer ◽  
Sesquiterpene Lactones ◽  
Human Cancer Cell ◽  
Human Cancer Cell Lines ◽  
Human Cancer Cells ◽  
Whole Plant

In search for plant-derived cytotoxicity compound against human cancer cells (A549, SK-OV-3, SK-MEL-2, XF498, HCT15), it was found that the chloroform extracts obtained from the whole plant of Carpesium rosulatum MlQ. (Compositae) exhibited significant cytotoxic activity. Four sesquiterpene lactone, CRC1 (2α, 5-epoxy-5,10-dihydroxy-6-angeloyl-oxy-9β-isobutyloxy-germacran-8α,12-olide), CRC2 (2α,5-epoxy-5,10-dihydroxy-6α,9β-diangeloyloxy-germacran-8α,12-olide), CRC3 (2α,5-epoxy-5,10-dihydroxy-6α-angeloyloxy-9β-(3-methyl-butanoyloxy)-gemacran-8α,12-olide), CRC4 (2β,5-epoxy-5,10-dihydroxy-6α,9β-diangeloyloxy-germacran-8α,12-olide) were isolated from the whole parts of C. rosulatum. 2α,5-epoxy-5,10-dihydroxy-6α,9β-diangeloyloxy-germacran-8α,12-olide (CRC2) showed the most potent cytotoxicity with IC50 value of 6.01 μM against SK-MEL-2.

Secondary Metabolites from a Culture of the Fungus Neosartorya pseudofischeri and Their In Vitro Cytostatic Activity in Human Cancer Cells

Planta Medica ◽  
2012 ◽  
Vol 78 (16) ◽  
pp. 1767-1776 ◽  
Author(s):  
Amnat Eamvijarn ◽  
Anake Kijjoa ◽  
Céline Bruyère ◽  
Véronique Mathieu ◽  
Leka Manoch ◽  
...  
Keyword(s):  
Secondary Metabolites ◽  
Cancer Cells ◽  
Human Cancer ◽  
Cytostatic Activity ◽  
Human Cancer Cells
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