Young Coconut Juice Supplementation Results in Greater Bone Mass and Bone Formation Indices in Ovariectomized Rats: A Preliminary Study

2015 ◽  
Vol 29 (12) ◽  
pp. 1950-1955 ◽  
Author(s):  
Yuko Morii ◽  
Hiroshi Matsushita ◽  
Akira Minami ◽  
Hiroaki Kanazawa ◽  
Takashi Suzuki ◽  
...  
Keyword(s):  
Bone Formation ◽  
Bone Mass ◽  
Ovariectomized Rats ◽  
Preliminary Study

scholarly journals A New Synthetic Steroid, Osaterone Acetate (TZP-4238), Increases Cortical Bone Mass and Strength by Enhancing Bone Formation in Ovariectomized Rats

1997 ◽  
Vol 12 (4) ◽  
pp. 590-597 ◽  
Author(s):  
Hiroaki Fuse ◽  
Seiji Fukumoto ◽  
Hideyuki Sone ◽  
Yoshiko Miyata ◽  
Tomoyuki Saito ◽  
...  
Keyword(s):  
Bone Formation ◽  
Bone Mass ◽  
Cortical Bone ◽  
Ovariectomized Rats ◽  
Cortical Bone Mass

Discovery of highly selective EP4 receptor agonists that stimulate new bone formation and restore bone mass in ovariectomized rats

2006 ◽  
Vol 16 (7) ◽  
pp. 1799-1802 ◽  
Author(s):  
Kimberly O. Cameron ◽  
Bruce A. Lefker ◽  
Margaret Y. Chu-Moyer ◽  
David T. Crawford ◽  
Paul DaSilva Jardine ◽  
...  
Keyword(s):  
Bone Formation ◽  
Bone Mass ◽  
Ovariectomized Rats ◽  
New Bone Formation ◽  
Receptor Agonists ◽  
Ep4 Receptor

Effects of Vitamin D3 Metabolites in Ovariectomized Rats

1989 ◽  
Vol 17 (3) ◽  
pp. 243-248
Author(s):  
H. Orimo ◽  
C. Tsutsumi ◽  
N. Hosoya ◽  
Y. Maeda ◽  
H. Yamato ◽  
...  
Keyword(s):  
Vitamin D ◽  
Bone Formation ◽  
Bone Mass ◽  
Dry Weight ◽  
Weight Basis ◽  
Ovariectomized Rats ◽  
Bone Gla Protein ◽  
Dihydroxyvitamin D ◽  
Vitamin D3 Metabolites ◽  
Stimulation Of

The effects of two vitamin D3 metabolites, 24 R,25-dihydroxyvitamin D3 and lα,25-dihydroxyvitamin D3, were investigated in ovariectomized rats. The amount of ash in the femur on a defatted dry weight basis was significantly greater in rats treated with 1 μg/kg 24 R,25-dihydroxyvitamin D3, or 0.01 or 0.1 μg/kg lα,25-dihydroxyvitamin D3 than in the controls. The concentration of bone gla protein in serum and amounts in the femur were significantly greater in rats treated with 1 or 10 Mg/kg 24 R,25-dihydroxyvitamin D3, but not those given 1α,25-dihydroxyvitamin D3 compared with the controls. These results suggest that 24 R,25-dihydroxyvitamin D3 increased bone mass probably through the stimulation of bone formation.

scholarly journals Increased Bone Formation and Bone Mass Induced by Sclerostin Antibody Is Not Affected by Pretreatment or Cotreatment with Alendronate in Osteopenic, Ovariectomized Rats

Endocrinology ◽  
2011 ◽  
Vol 152 (9) ◽  
pp. 3312-3322 ◽  
Author(s):  
Xiaodong Li ◽  
Michael S. Ominsky ◽  
Kelly S. Warmington ◽  
Qing-Tian Niu ◽  
Franklin J. Asuncion ◽  
...  
Keyword(s):  
Bone Formation ◽  
Bone Mass ◽  
Ovariectomized Rats ◽  
Sclerostin Antibody

Dietary fish oil results in a greater bone mass and bone formation indices in aged ovariectomized rats

2008 ◽  
Vol 26 (3) ◽  
pp. 241-247 ◽  
Author(s):  
Hiroshi Matsushita ◽  
Jill A. Barrios ◽  
Jill E. Shea ◽  
Scott C. Miller
Keyword(s):  
Bone Formation ◽  
Bone Mass ◽  
Fish Oil ◽  
Ovariectomized Rats ◽  
Dietary Fish

Time course of disassociation of bone formation signals with bone mass and bone strength in sclerostin antibody treated ovariectomized rats

Bone ◽  
2017 ◽  
Vol 97 ◽  
pp. 20-28 ◽  
Author(s):  
Yanfei L Ma ◽  
Matthew Hamang ◽  
Jonathan Lucchesi ◽  
Nicoletta Bivi ◽  
Qianqiang Zeng ◽  
...  
Keyword(s):  
Bone Formation ◽  
Bone Mass ◽  
Bone Strength ◽  
Time Course ◽  
Ovariectomized Rats ◽  
Sclerostin Antibody

β-Blocker and Other Analogous Treatments that Affect Bone Mass and Sympathetic Nerve Activity in Ovariectomized Rats

2007 ◽  
Vol 35 (01) ◽  
pp. 89-101 ◽  
Author(s):  
Wenping Zhang ◽  
Masayuki Kanehara ◽  
Yanjun Zhang ◽  
Xiaoming Wang ◽  
Torao Ishida
Keyword(s):  
Bone Formation ◽  
Bone Mass ◽  
Formation Rate ◽  
Chinese Herbs ◽  
Ovariectomized Rats ◽  
Mineral Apposition Rate ◽  
Control Group ◽  
Bone Formation Rate ◽  
Ovx Rats ◽  
Bone Formation Markers

We investigated whether treatments with beta-blockers or other administrations that have similar actions to β-blockers, such as Chinese herbs or needling, were effective in treating osteoporosis induced by ovariectomy (OVX). Female Wister rats were divided into five groups: a sham-operated control group treated with vehicle (Sham, n = 8), an ovariectomized (OVX) group treated with vehicle (Model, n = 8), an OVX group administered with propranolol (Pro, n = 10), an OVX group administered an ethanol extract of Fructus Citri Sarcodactylis (Fcs, n = 9), and an OVX punctured at Sanyinjiao (SP-6) and Neiguan (PC-6) (Needling, n = 8). The treatment started when rats were 12 weeks old and continued for 24 weeks. Serum osteocalcin and urinary deoxypyridinoline (Dpd) levels were upregulated in rats in response to OVX, together with a significantly decreased BMD and trabecular bone area. The Pro, Fcs and Needling treatment improved the decreased BMD and the trabecular area, increased the trabecular number, lowered the trabecular separation to some extent as well as significantly depressed the urinary Dpd levels ( p < 0.05). The bone formation markers, such as the mineralizing surface, mineral apposition rate and bone formation rate were not significantly changed, along with a slightly higher trend of osteocalcin levels when compared with the Model rats. The slower heart rate and lower plasma NE levels in these therapeutic groups were also found. Our results suggested that propranolol, Fcs and needling on Sanyinjiao (SP-6) and Neiguan (PC-6) may improve the bone mass of OVX rats, and it provides an alternative and potential therapy for the prevention of postmenopausal osteoporosis.

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