Pachymic Acid Induces Apoptosis of EJ Bladder Cancer Cells by DR5 Up-Regulation, ROS Generation, Modulation of Bcl-2 and IAP Family Members

2015 ◽  
Vol 29 (10) ◽  
pp. 1516-1524 ◽  
Author(s):  
Jin-Woo Jeong ◽  
Won Sup Lee ◽  
Se-il Go ◽  
Arulkumar Nagappan ◽  
Jun Young Baek ◽  
...  
Keyword(s):  
Bladder Cancer ◽  
Cancer Cells ◽  
Family Members ◽  
Ros Generation ◽  
Pachymic Acid ◽  
Bladder Cancer Cells

scholarly journals Induction of Apoptosis by Costunolide in Bladder Cancer Cells is Mediated through ROS Generation and Mitochondrial Dysfunction

Molecules ◽  
2013 ◽  
Vol 18 (2) ◽  
pp. 1418-1433 ◽  
Author(s):  
Azhar Rasul ◽  
Rui Bao ◽  
Mahadev Malhi ◽  
Bing Zhao ◽  
Ichiro Tsuji ◽  
...  
Keyword(s):  
Bladder Cancer ◽  
Mitochondrial Dysfunction ◽  
Cancer Cells ◽  
Ros Generation ◽  
Bladder Cancer Cells ◽  
Induction Of Apoptosis

TRAIL attenuates sulforaphane-mediated Nrf2 and sustains ROS generation, leading to apoptosis of TRAIL-resistant human bladder cancer cells

2018 ◽  
Vol 352 ◽  
pp. 132-141 ◽  
Author(s):  
Cheng-Yun Jin ◽  
Ilandarage Menu Neelaka Molagoda ◽  
Wisurumuni Arachchilage Hasitha Maduranga Karunarathne ◽  
Sang-Hyuck Kang ◽  
Cheol Park ◽  
...  
Keyword(s):  
Bladder Cancer ◽  
Cancer Cells ◽  
Ros Generation ◽  
Human Bladder Cancer ◽  
Human Bladder ◽  
Bladder Cancer Cells ◽  
Human Bladder Cancer Cells

scholarly journals Induction of Apoptosis by Pachymic Acid in T24 Human Bladder Cancer Cells

2015 ◽  
Vol 25 (1) ◽  
pp. 93-100 ◽  
Author(s):  
Jin-Woo Jeong ◽  
Jun Young Baek ◽  
Kwang Dong Kim ◽  
Yung Hyun Choi ◽  
Jae-Dong Lee
Keyword(s):  
Bladder Cancer ◽  
Cancer Cells ◽  
Human Bladder Cancer ◽  
Human Bladder ◽  
Pachymic Acid ◽  
Bladder Cancer Cells ◽  
Induction Of Apoptosis ◽  
Human Bladder Cancer Cells

scholarly journals Liposome-Encapsulated Bacillus Calmette–Guérin Cell Wall Skeleton Enhances Antitumor Efficiency for Bladder Cancer In Vitro and In Vivo via Induction of AMP-Activated Protein Kinase

Cancers ◽  
2020 ◽  
Vol 12 (12) ◽  
pp. 3679
Author(s):  
Young Mi Whang ◽  
Da Hyeon Yoon ◽  
Gwang Yong Hwang ◽  
Hoyub Yoon ◽  
Serk In Park ◽  
...  
Keyword(s):  
Bladder Cancer ◽  
Cell Wall ◽  
Protein Kinase ◽  
Cancer Cells ◽  
Ros Generation ◽  
Bacillus Calmette Guerin ◽  
Bladder Cancer Cells ◽  
Amp Activated Protein Kinase

The Mycobacterium Bacillus Calmette-Guérin cell wall skeleton (BCG-CWS), the main immune active center of BCG, is a potent candidate non-infectious immunotherapeutic drug and an alternative to live BCG for use against urothelial carcinoma. However, its application in anticancer therapy is limited, as BCG-CWS tends to aggregate in both aqueous and non-aqueous solvents. To improve the internalization of BCG-CWS into bladder cancer cells without aggregation, BCG-CWS was nanoparticulated at a 180 nm size in methylene chloride and subsequently encapsulated with conventional liposomes (CWS-Nano-CL) using an emulsified lipid (LEEL) method. In vitro cell proliferation assays showed that CWS-Nano-CL was more effective at suppressing bladder cancer cell growth compared to nonenveloped BCG-CWS. In an orthotopic implantation model of luciferase-tagged MBT2 bladder cancer cells, encapsulated BCG-CWS nanoparticles could enhance the delivery of BCG-CWS into the bladder and suppress tumor growth. Treatment with CWS-Nano-CL induced the inhibition of the mammalian target of rapamycin (mTOR) pathway and the activation of AMP-activated protein kinase (AMPK) phosphorylation, leading to apoptosis, both in vitro and in vivo. Furthermore, the antitumor activity of CWS-Nano-CL was mediated predominantly by reactive oxygen species (ROS) generation and AMPK activation, which induced endoplasmic reticulum (ER) stress, followed by c-Jun N-terminal kinase (JNK) signaling-mediated apoptosis. Therefore, our data suggest that the intravesical instillation of liposome-encapsulated BCG-CWS nanoparticles can facilitate BCG-CW cellular endocytosis and provide a promising drug-delivery system as a therapeutic strategy for BCG-mediated bladder cancer treatment.

758: Inflammatory and Anti-Inflammatory Regulators alter Levels of an Inhibitor of Apoptosis (IAP), Survivin, in T-24 Bladder Cancer Cells

2007 ◽  
Vol 177 (4S) ◽  
pp. 254-254
Author(s):  
Justin J. Cohen ◽  
Bayan T. Takizawa ◽  
Hristos Z. Kaimkliotis ◽  
David J. Rosenberg ◽  
Marcia A. Wheeler ◽  
...  
Keyword(s):  
Bladder Cancer ◽  
Cancer Cells ◽  
Inhibitor Of Apoptosis ◽  
Bladder Cancer Cells ◽  
Anti Inflammatory

792: Role of Oxidative Stress in Tumorigenic Potential of Bladder Cancer Cells

2005 ◽  
Vol 173 (4S) ◽  
pp. 214-215 ◽  
Author(s):  
Daniel Cho ◽  
Xiao Fang Ha ◽  
J. Andre Melendez ◽  
Louis J. Giorgi ◽  
Badar M. Mian
Keyword(s):  
Oxidative Stress ◽  
Bladder Cancer ◽  
Cancer Cells ◽  
Tumorigenic Potential ◽  
Bladder Cancer Cells

627: Multitarget Gene Inhibition by Synthetic Nucleic Acids in Bladder Cancer Cells

2006 ◽  
Vol 175 (4S) ◽  
pp. 202-202 ◽  
Author(s):  
Yvonne Burmeister ◽  
Kai Kraemer ◽  
Susanne Fuessel ◽  
Matthias Kotzsch ◽  
Axel Meye ◽  
...  
Keyword(s):  
Bladder Cancer ◽  
Nucleic Acids ◽  
Cancer Cells ◽  
Bladder Cancer Cells ◽  
Gene Inhibition

723: Chemokine Receptor CXCR4 Mediates Migration and Invasion of Bladder Cancer Cells

2004 ◽  
Vol 171 (4S) ◽  
pp. 192-192 ◽  
Author(s):  
Margitta Retz ◽  
Sukhvinder S. Sidhu ◽  
Gregory M. Dolganov ◽  
Jan Lehmann ◽  
Peter R. Carroll ◽  
...  
Keyword(s):  
Bladder Cancer ◽  
Cancer Cells ◽  
Chemokine Receptor ◽  
Migration And Invasion ◽  
Chemokine Receptor Cxcr4 ◽  
Bladder Cancer Cells

Pirarubicin inhibits proliferation of bladder cancer cells through PLCε-Bcl-2 pathway

2014 ◽  
Vol 35 (7) ◽  
pp. 708
Author(s):  
Li-ping OU ◽  
Hong-fei DU ◽  
Chang-kun Lv ◽  
Xue-dong SONG ◽  
Yan-ru FAN ◽  
...  
Keyword(s):  
Bladder Cancer ◽  
Cancer Cells ◽  
Bladder Cancer Cells
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