Pharmacological Basis for Medicinal Use ofLens culinarisin Gastrointestinal and Respiratory Disorders

2014 ◽  
Vol 28 (9) ◽  
pp. 1349-1358 ◽  
Author(s):  
Munasib Khan ◽  
Arif-ullah Khan ◽  
Najeeb-ur- Rehman ◽  
Anwarul-Hassan Gilani
Keyword(s):  
Respiratory Disorders ◽  
Medicinal Use ◽  
Pharmacological Basis

Pharmacological basis for the medicinal use of Carissa carandas in constipation and diarrhea

2014 ◽  
Vol 153 (2) ◽  
pp. 359-367 ◽  
Author(s):  
Malik Hassan Mehmood ◽  
Nfn Anila ◽  
Sabira Begum ◽  
Saqib A. Syed ◽  
Bina S. Siddiqui ◽  
...  
Keyword(s):  
Medicinal Use ◽  
Carissa Carandas ◽  
Pharmacological Basis

scholarly journals Pharmacological Basis for the Medicinal Use ofLepidium sativumin Airways Disorders

2012 ◽  
Vol 2012 ◽  
pp. 1-8 ◽  
Author(s):  
Najeeb-ur Rehman ◽  
Arif-ullah Khan ◽  
Khalid M. Alkharfy ◽  
Anwarul-Hassan Gilani
Keyword(s):  
Crude Extract ◽  
Folk Medicine ◽  
Maximum Response ◽  
Lepidium Sativum ◽  
Response Curves ◽  
Leftward Shift ◽  
Inhibitory Pathways ◽  
Low Concentrations ◽  
Medicinal Use ◽  
Pharmacological Basis

Lepidium sativumis widely used in folk medicine for treatment of hyperactive airways disorders, such as asthma, bronchitis and cough. The crude extract ofLepidium sativum(Ls.Cr) inhibited carbachol (CCh, 1 μM-) and K+(80 mM-) induced contractions in a pattern similar to that of dicyclomine. Ls.Cr at 0.03 mg/mL produced a rightward parallel shift of CCh curves, followed by nonparallel shift at higher concentration (0.1 mg/mL), suppressing maximum response, similar to that caused by dicyclomine. Pretreatment of tissues with Ls.Cr (0.1–0.3 mg/mL) shifted Ca++concentration-response curves (CRCs) to right, as produced by verapamil. Ls.Cr at low concentrations (0.03–0.1 mg/mL) caused leftward shift of isoprenaline-induced inhibitory CRCs, like that caused by rolipram, a phosphodiesterase (PDE) inhibitor. These results indicate that bronchodilatory effect ofLepidium sativumis mediated through a combination of anticholinergic, Ca++antagonist and PDE inhibitory pathways, which provides sound mechanistic background for its medicinal use in the overactive airways disorders.

Pharmacological explanation for the medicinal use of Juniperus excelsa in hyperactive gastrointestinal and respiratory disorders

2011 ◽  
Vol 66 (2) ◽  
pp. 292-301 ◽  
Author(s):  
Munasib Khan ◽  
Arif-ullah Khan ◽  
Najeeb-ur-Rehman ◽  
Anwarul-Hassan Gilani
Keyword(s):  
Respiratory Disorders ◽  
Medicinal Use ◽  
Juniperus Excelsa

scholarly journals Pharmacological basis for the medicinal use of Rhus coriaria in hyperactive gut disorders

2014 ◽  
Vol 9 (4) ◽  
Author(s):  
Khalid Hussain Janbaz ◽  
Arham Shabbir ◽  
Malik Hassan Mehmood ◽  
Anwarul Hassan Gilani
Keyword(s):  
Medicinal Use ◽  
Rhus Coriaria ◽  
Pharmacological Basis

Pharmacological basis for the use of turmeric in gastrointestinal and respiratory disorders

Life Sciences ◽  
2005 ◽  
Vol 76 (26) ◽  
pp. 3089-3105 ◽  
Author(s):  
Anwarul Hassan Gilani ◽  
Abdul Jabbar Shah ◽  
Muhammad Nabeel Ghayur ◽  
Kashif Majeed
Keyword(s):  
Respiratory Disorders ◽  
Pharmacological Basis

Pharmacological basis for the medicinal use ofHolarrhena antidysentericain gut motility disorders

2010 ◽  
Vol 48 (11) ◽  
pp. 1240-1246 ◽  
Author(s):  
Anwarul Hassan Gilani ◽  
Aslam Khan ◽  
Arif-ullah Khan ◽  
Samra Bashir ◽  
Najeeb-ur Rehman ◽  
...  
Keyword(s):  
Gut Motility ◽  
Motility Disorders ◽  
Medicinal Use ◽  
Pharmacological Basis

Dual Inhibition of Ca+2Influx and Phosphodiesterase Enzyme Provides Scientific Base for the Medicinal Use ofChrozophora prostrataDalz. in Respiratory Disorders

2016 ◽  
Vol 30 (6) ◽  
pp. 1010-1015 ◽  
Author(s):  
Usman Arshad ◽  
Samra Bashir ◽  
Najeeb -ur-Rehman ◽  
Tahir Yaqub ◽  
Anwarul-Hassan Gilani
Keyword(s):  
Respiratory Disorders ◽  
Medicinal Use ◽  
Dual Inhibition ◽  
Scientific Base

scholarly journals Pharmacological basis for medicinal use of Ziziphyus nummularia (Rhamnaceae) leaves in gastrointestinal disorders

2017 ◽  
Vol 16 (10) ◽  
pp. 2379-2385
Author(s):  
Sayed Muzahir Hussain ◽  
Aslam Khan ◽  
Arif-ullah Khan ◽  
Neelum Gul Qazi ◽  
Fawad Ali
Keyword(s):  
Castor Oil ◽  
Saline Group ◽  
Antagonistic Effect ◽  
Fluid Accumulation ◽  
Response Curves ◽  
Medicinal Use ◽  
Gastrointestinal Ulcer ◽  
Rabbit Jejunum ◽  
Ziziphus Nummularia ◽  
Pharmacological Basis

Purpose: To explore the pharmacological basis for the folkloric use of Ziziphus nummularia for treating diarrhea and gastrointestinal spasm.Methods: Ziziphus nummularia crude extract (Zn.Cr) was investigated for  antidiarrheal activity (50, 100 and 300 mg/kg) in terms of reduction diarrhea  droppings as well as for antisecretory activity (300 and 1000 mg/kg) in castor-oil induced model in mice. The effect of the extract on potassium chloride (KCl, 80 mM)-induced contractions in isolated rabbit jejunum tissues were was also  examined. Furthermore, the antiulcer properties of the extract was assessed in an ethanol-induced gastrointestinal ulcer model.Results: Zn.Cr (50 – 1000 mg/kg) exhibited protective effect against castor  oil-induced diarrhea (p <0.05, p < 0.01 vs saline group) and intestinal fluid  accumulation (p < 0.001 vs. castor oil group) in mice. In isolated rabbit jejunum model, Zn.Cr concentration-dependently (0.01, 0.1, 0.3, 0.5, 1 and 3 mg/mL) caused relaxation of spontaneous and KCl-induced contractions, similar to  verapamil. Calcium antagonistic effect was indicated, as pretreatment of intestinal tissues with Zn.Cr (0.3, 0.5 and 1.0 mg/mL) produced a rightward shift in Ca2+ concentration-response curves, with suppression of maximum contraction. In ethanol-induced gastric ulceration assay, Zn.Cr (300 and 1000 mg/kg) caused52.5 and 93.6 % inhibition, respectively (p < 0.001 vs. saline group).Conclusion: These results reveal that Ziziphus nummularia possesses anti-diarrheal, anti-secretory, anti-spasmodic and anti-ulcer actions, mediated possibly through voltage-gated Ca2+channel blockade.Keywords: Ziziphus nummularia, Anti-diarrheal, Anti-secretory, Anti-spasmodic, Anti-ulcer

scholarly journals Pharmacological basis for the medicinal use of Viola odorata in diarrhea, bronchial asthma and hypertension

2015 ◽  
Vol 10 (4) ◽  
pp. 836 ◽  
Author(s):  
Khalid Hussain Janbaz ◽  
Waseem Ullah Khan ◽  
Fatima Saqib ◽  
Mamoona Khalid
Keyword(s):  
Channel Blocker ◽  
Response Curves ◽  
Relaxant Effect ◽  
Viola Odorata ◽  
Medicinal Use ◽  
Channel Blocking ◽  
Blocking Activity ◽  
Rabbit Jejunum ◽  
Spontaneous Contractions ◽  
Pharmacological Basis

<p class="Abstract"><em>Viola odorata</em> is traditionally used in the management of gastrointestinal,  respiratory and vascular disorders. The present study was undertaken to validate its folkloric uses. The application of <em>V. odorata</em> to spontaneous contractions in isolated rabbit jejunum preparation exerted relaxant effect through decrease in magnitude and frequency of contractions. Moreover, it also caused relaxation of K<sup>+ </sup>(80 mM)-induced contractions and shifted the Ca<sup>2+ </sup>concentration response curves toward right in isolated jejunum similar to verapamil (standard Ca<sup>2+ </sup>channel blocker), confirming Ca<sup>2+ </sup>channel blocking activity. <em>V. odorata</em> also caused relaxation of carbachol (1 µM)- and K<sup>+ </sup>(80 mM)-induced contractions in isolated rabbit tracheal preparations comparable to verapamil, reflecting that observed relaxant effect may be the outcome of anti-muscarinic and/or Ca<sup>2+ </sup>channel blocking activities. It also exerted relaxant effect on phenylephrine (1 µM)- and K<sup>+ </sup>(80 mM)-induced contractions in isolated rabbit aortic preparations thus providing rationale for  its folkloric  uses to treat diarrhea, asthma and hypertension.</p>

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