Ginsenoside Rg3 Up-regulates the Expression of Vascular Endothelial Growth Factor in Human Dermal Papilla Cells and Mouse Hair Follicles

2013 ◽  
Vol 28 (7) ◽  
pp. 1088-1095 ◽  
Author(s):  
Dae Hyun Shin ◽  
Youn Jeong Cha ◽  
Kyeong Eun Yang ◽  
Ik-Soon Jang ◽  
Chang-Gue Son ◽  
...  
Keyword(s):  
Vascular Endothelial Growth Factor ◽  
Growth Factor ◽  
Dermal Papilla ◽  
Hair Follicles ◽  
Vascular Endothelial ◽  
Ginsenoside Rg3 ◽  
Dermal Papilla Cells ◽  
Endothelial Growth Factor

scholarly journals Vascular Endothelial Growth Factor Is an Autocrine Growth Factor for Hair Dermal Papilla Cells

1996 ◽  
Vol 106 (1) ◽  
pp. 17-23 ◽  
Author(s):  
Souad Lachgar ◽  
Hafida Moukadiri ◽  
Frédéric Jonca ◽  
Marie Charveron ◽  
Nadia Bouhaddioui ◽  
...  
Keyword(s):  
Vascular Endothelial Growth Factor ◽  
Growth Factor ◽  
Dermal Papilla ◽  
Vascular Endothelial ◽  
Autocrine Growth ◽  
Dermal Papilla Cells ◽  
Autocrine Growth Factor ◽  
Endothelial Growth Factor

scholarly journals Expression of Vascular Endothelial Growth Factor Receptors 1, 2, and 3 in Quiescent Endothelia

2002 ◽  
Vol 50 (6) ◽  
pp. 767-777 ◽  
Author(s):  
Antonella N. Witmer ◽  
Jiapei Dai ◽  
Herbert A. Weich ◽  
Gijs F.J.M. Vrensen ◽  
Reinier O. Schlingemann
Keyword(s):  
Vascular Endothelial Growth Factor ◽  
Growth Factor ◽  
Distribution Patterns ◽  
Hair Follicles ◽  
Electron Microscopic Level ◽  
Lymphoid Tissues ◽  
Vascular Endothelial ◽  
Physiological Functions ◽  
Normal Human ◽  
Endothelial Growth Factor

The vascular endothelial growth factor (VEGF) family is involved in angiogenesis, and therefore VEGFs are considered as targets for anti-angiogenic therapeutic strategies against cancer. However, the physiological functions of VEGFs in quiescent tissues are unclear and may interfere with such systemic therapies. In pathological conditions, increased levels of expression of the VEGF receptors VEGFR-1, VEGFR-2, and VEGFR-3 accompany VEGF activity. In this study we investigated normal human and monkey tissues for expression patterns of these receptors. Immunohistochemical staining methods at the light and electron microscopic level were applied to normal human and monkey tissue samples, using monoclonal antibodies (MAbs) against the three VEGFRs and anti-endothelial MAbs PAL-E and anti-CD31 to identify blood and lymph vessels. In human and monkey, similar distribution patterns of the three VEGFRs were found. Co-expression of VEGFR-1, −2, and −3 was observed in microvessels adjacent to epithelia in the eye, gastrointestinal mucosa, liver, kidney, and hair follicles, which is in line with the reported preferential expression of VEGF-A in some of these epithelia. VEGFR-1, −2, and −3 expression was also observed in blood vessels and sinusoids of lymphoid tissues. Furthermore, VEGFR-1, but not VEGFR-2 and −3, was present in microvessels in brain and retina. Electron microscopy showed that VEGFR-1 expression was restricted to pericytes and VEGFR-2 to endothelial cells in normal vasculature of tonsils. These findings indicate that VEGFRs have specific distribution patterns in normal tissues, suggesting physiological functions of VEGFs that may be disturbed by systemic anti-VEGF therapy. One of these functions may be involvement of VEGF in paracrine relations between epithelia and adjacent capillaries.

scholarly journals Kojyl Cinnamate Ester Derivatives Increase Adiponectin Expression and Stimulate Adiponectin-Induced Hair Growth Factors in Human Dermal Papilla Cells

2019 ◽  
Vol 20 (8) ◽  
pp. 1859 ◽  
Author(s):  
Phil June Park ◽  
Eun-Gyung Cho
Keyword(s):  
Growth Factors ◽  
Growth Factor ◽  
Mrna Expression ◽  
Hair Growth ◽  
Subcutaneous Fat ◽  
Dermal Papilla ◽  
Hair Follicles ◽  
Dermal Papilla Cells ◽  
Glucose Levels ◽  
Endothelial Growth Factor

Adiponectin (APN), released mainly from adipose tissue, is a well-known homeostatic factor for regulating glucose levels, lipid metabolism, and insulin sensitivity. A recent study showed that human hair follicles express APN receptors and the presence of APN-mediated hair growth signaling, thereby suggesting that APN is a potent hair growth-promoting adipokine. Previously, kojyl cinnamate ester derivatives (KCEDs) were synthesized in our institute as new anti-aging or adiponectin-/adipogenesis-inducing compounds. Here, we tested the activity of these derivatives to induce endogenous APN secretion. Among the derivatives, KCED-1 and KCED-2 showed improved activity in inducing APN mRNA expression, secretion of APN protein, and adipogenesis in human subcutaneous fat cells (hSCFs) when compared with the effects of Seletinoid G, a verified APN inducer. When human follicular dermal papilla cells were treated with the culture supernatant of KCED-1- or KCED-2-treated hSCFs, the mRNA expression of APN-induced hair growth factors such as insulin-like growth factor, hepatocyte growth factor, and vascular endothelial growth factor was upregulated compared with that in the control. Taken together, our study shows that among kojyl cinnamate ester derivatives, KCED-1, KCED-2, as well as Seletinoid G are effective inducers of endogenous APN production in subcutaneous fat tissues, which may in turn contribute to the promotion of hair growth in the human scalp.

scholarly journals Loss of Vascular Endothelial Growth Factor in Human Alopecia Hair Follicles

1995 ◽  
Vol 104 (5) ◽  
pp. 18-20 ◽  
Author(s):  
Corey K. Goldman ◽  
Jui-Chang Tsai ◽  
Liliana Soroceanu ◽  
G. Yancey Gillespie
Keyword(s):  
Vascular Endothelial Growth Factor ◽  
Growth Factor ◽  
Hair Follicles ◽  
Vascular Endothelial ◽  
Endothelial Growth Factor
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