Inhibition of TNF-α-Induced MUC5AC Mucin Gene Expression and Production by Wogonin Through the Inactivation of NF-κB Signaling in Airway Epithelial Cells

2013 ◽  
Vol 28 (1) ◽  
pp. 62-68 ◽  
Author(s):  
Md. Asaduzzaman Sikder ◽  
Hyun Jae Lee ◽  
Md. Zakaria Mia ◽  
Su Hyun Park ◽  
Jiho Ryu ◽  
...  
Keyword(s):  
Gene Expression ◽  
Epithelial Cells ◽  
Airway Epithelial Cells ◽  
Airway Epithelial ◽  
Mucin Gene ◽  
Tnf Α

scholarly journals Effect of Berberine on MUC5AC Mucin Gene Expression and Mucin Production from Human Airway Epithelial Cells

2011 ◽  
Vol 19 (3) ◽  
pp. 320-323 ◽  
Author(s):  
Md. Asaduzzaman Sikder ◽  
Hyun-Jae Lee ◽  
Su-Yel Lee ◽  
Heung-Seog Bae ◽  
Jang-Hyun Kim ◽  
...  
Keyword(s):  
Gene Expression ◽  
Epithelial Cells ◽  
Airway Epithelial Cells ◽  
Airway Epithelial ◽  
Mucin Production ◽  
Human Airway ◽  
Mucin Gene ◽  
Human Airway Epithelial Cells

Resistin upregulates MUC5AC/B mucin gene expression in human airway epithelial cells

2018 ◽  
Vol 499 (3) ◽  
pp. 655-661 ◽  
Author(s):  
Soyoung Kwak ◽  
Yong-Dae Kim ◽  
Hyung Gyun Na ◽  
Chang Hoon Bae ◽  
Si-Youn Song ◽  
...  
Keyword(s):  
Gene Expression ◽  
Epithelial Cells ◽  
Airway Epithelial Cells ◽  
Airway Epithelial ◽  
Human Airway ◽  
Mucin Gene ◽  
Human Airway Epithelial Cells

Regulation of RANTES promoter activation in alveolar epithelial cells after cytokine stimulation

2002 ◽  
Vol 283 (6) ◽  
pp. L1280-L1290 ◽  
Author(s):  
Antonella Casola ◽  
Allyne Henderson ◽  
Tianshuang Liu ◽  
Roberto P. Garofalo ◽  
Allan R. Brasier
Keyword(s):  
Gene Expression ◽  
Epithelial Cells ◽  
Viral Infection ◽  
Molecular Mechanisms ◽  
Airway Epithelial Cells ◽  
Airway Epithelial ◽  
Mrna Stabilization ◽  
Tnf Α ◽  
Ifn Γ ◽  
Responsive Element

Regulated on activation, normal T cell expressed, and presumably secreted (RANTES) is a member of the CC chemokine family of proteins implicated in a variety of diseases characterized by lung eosinophilia and inflammation, strongly produced by stimulated airway epithelial cells. Because such cytokines as tumor necrosis factor (TNF)-α and interferon-γ (IFN-γ) have been shown to enhance RANTES induction in airway epithelial cells and RANTES gene expression appears to be differentially regulated depending on the cell type and the stimulus applied, in this study we have elucidated mechanisms that operate to control RANTES induction on exposure to TNF-α and/or IFN-γ. Our results indicate that TNF-α and IFN-γ synergistically induce RANTES protein secretion and mRNA expression. RANTES transcription is activated only after stimulation with TNF-α, but not IFN-γ, which affects RANTES mRNA stabilization. Promoter deletion and mutagenesis experiments indicate that the nuclear factor (NF)-κB site is the most important cis-regulatory element controlling TNF-induced RANTES transcription, although NF-interleukin-6 binding site, cAMP responsive element (CRE), and interferon-stimulated responsive element (ISRE) also play a significant role. TNF-α stimulation induces nuclear translocation of interferon regulatory factor (IRF)-3, which in viral infection binds the RANTES ISRE and is necessary for activation of RANTES transcription. However, TNF-induced IRF-3 translocation does not result in IRF-3 binding to the RANTES ISRE. Although viral infection can activate an ISRE-driven promoter, TNF cannot, indicating that RANTES gene enhancers are controlled in a stimulus-specific fashion. Identification of molecular mechanisms involved in RANTES gene expression is fundamental for developing strategies to modulate lung inflammatory responses.

scholarly journals Rhinovirus-Induced Mucin Gene Expression in Airway Epithelial Cells

2009 ◽  
Vol 52 (8) ◽  
pp. 670 ◽  
Author(s):  
Yong Ju Jang ◽  
Hyun Ja Kwon ◽  
Jong Whan Wang ◽  
Bong-Jae Lee ◽  
Yoo-Sam Chung
Keyword(s):  
Gene Expression ◽  
Epithelial Cells ◽  
Airway Epithelial Cells ◽  
Airway Epithelial ◽  
Mucin Gene

46 HYPERCAPNIA INDUCES MUCIN GENE EXPRESSION IN HUMAN AIRWAY EPITHELIAL CELLS.

2006 ◽  
Vol 54 (2) ◽  
pp. S351.1-S351
Author(s):  
N. Wang ◽  
M. C. Nlend ◽  
A. Nair ◽  
J. I. Sznajder ◽  
P. H.S. Sporn
Keyword(s):  
Gene Expression ◽  
Epithelial Cells ◽  
Airway Epithelial Cells ◽  
Airway Epithelial ◽  
Human Airway ◽  
Mucin Gene ◽  
Human Airway Epithelial Cells

Resveratrol Inhibits Mucin Gene Expression, Production and Secretion From Airway Epithelial Cells

2011 ◽  
Vol 26 (7) ◽  
pp. 1082-1087 ◽  
Author(s):  
Su Yel Lee ◽  
Hyun Jae Lee ◽  
Md. Asaduzzaman Sikder ◽  
Hyun-Dae Shin ◽  
Jang-Hyun Kim ◽  
...  
Keyword(s):  
Gene Expression ◽  
Epithelial Cells ◽  
Airway Epithelial Cells ◽  
Airway Epithelial ◽  
Mucin Gene

Human Airway Trypsin-Like Protease Increases Mucin Gene Expression in Airway Epithelial Cells

2004 ◽  
Vol 30 (4) ◽  
pp. 470-478 ◽  
Author(s):  
Manabu Chokki ◽  
Satoshi Yamamura ◽  
Hiroshi Eguchi ◽  
Tsukio Masegi ◽  
Hideki Horiuchi ◽  
...  
Keyword(s):  
Gene Expression ◽  
Epithelial Cells ◽  
Airway Epithelial Cells ◽  
Airway Epithelial ◽  
Human Airway ◽  
Mucin Gene
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