scholarly journals Cannabis sativa and the Endogenous Cannabinoid System: Therapeutic Potential for Appetite Regulation

2011 ◽  
Vol 25 (2) ◽  
pp. 170-188 ◽  
Author(s):  
Jonathan A. Farrimond ◽  
Marion S. Mercier ◽  
Benjamin J. Whalley ◽  
Claire M. Williams
e-Neuroforum ◽  
2012 ◽  
Vol 18 (4) ◽  
Author(s):  
E. Drews ◽  
A. Zimmer

AbstractThe hemp plant Cannabis sativa has been cultivated for thousands of years and is used as a medical plant and intoxicant. Scientif­ic research on the psychoactive substances of Cannabis sativa and their effects on the brain started around 50 years ago and led to the discovery of the endogenous cannabi­noid system. Today we know that this system represents an important feedback mechanism that modulates the communication be­tween neurons. However, this system is not only active in the brain, but is known to be activated in different tissues and organs during specific disease states. Consequently, there is increasing interest in this system as a possible target for the development of new drugs. The currently commercially available drugs are based on cannabis extracts or synthetic compounds of the plant’s active components and are mainly used to treat chron­ic pain. In this review, the mechanisms of the endogenous cannabinoid system in pain perception are elucidated and a new herbal (phyto)cannabinoid which is a constituent of our daily food is presented.


PLoS ONE ◽  
2008 ◽  
Vol 3 (3) ◽  
pp. e1797 ◽  
Author(s):  
Blerina Kola ◽  
Imre Farkas ◽  
Mirjam Christ-Crain ◽  
Gábor Wittmann ◽  
Francesca Lolli ◽  
...  

Nature ◽  
2002 ◽  
Vol 418 (6897) ◽  
pp. 530-534 ◽  
Author(s):  
Giovanni Marsicano ◽  
Carsten T. Wotjak ◽  
Shahnaz C. Azad ◽  
Tiziana Bisogno ◽  
Gerhard Rammes ◽  
...  

2001 ◽  
Vol 15 (14) ◽  
pp. 1-17 ◽  
Author(s):  
Maurizio Bifulco ◽  
Chiara Laezza ◽  
Giuseppe Portella ◽  
Mario Vitale ◽  
Pierangelo Orlando ◽  
...  

Author(s):  
Balapal S. Basavarajappa ◽  
Vikram Joshi ◽  
Madhu Shivakumar ◽  
Shivakumar Subbanna

2000 ◽  
Vol 23 (1) ◽  
pp. 14-20 ◽  
Author(s):  
Javier Fernández-Ruiz ◽  
Fernando Berrendero ◽  
Mari Luz Hernández ◽  
José A Ramos

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