Inhibition of TNF-α-mediated endothelial cell-monocyte cell adhesion and adhesion molecules expression by the resveratrol derivative, trans-3,5,4′-trimethoxystilbene

2010 ◽  
pp. n/a-n/a ◽  
Author(s):  
Yan-Hui Deng ◽  
Deepa Alex ◽  
He-Qing Huang ◽  
Nan Wang ◽  
Nan Yu ◽  
...  
Keyword(s):  
Cell Adhesion ◽  
Endothelial Cell ◽  
Adhesion Molecules ◽  
Tnf Α ◽  
Monocyte Cell ◽  
Resveratrol Derivative

scholarly journals Endothelial cell adhesion molecule expression in gene-targeted mice

1997 ◽  
Vol 273 (4) ◽  
pp. H1903-H1908 ◽  
Author(s):  
Michael J. Eppihimer ◽  
Janice Russell ◽  
Donald C. Anderson ◽  
Barry A. Wolitzky ◽  
D. Neil Granger
Keyword(s):  
Cell Adhesion ◽  
Endothelial Cell ◽  
Adhesion Molecules ◽  
Cell Adhesion Molecules ◽  
Wild Type ◽  
Tnf Α ◽  
Endothelial Cell Adhesion Molecules ◽  
Vascular Beds ◽  
Deficient Mice ◽  
Endothelial Cell Adhesion

Gene-targeted mice are now routinely employed as tools for defining the contribution of different leukocyte and endothelial cell adhesion molecules to the leukocyte recruitment and tissue injury associated with acute and chronic inflammation. The objective of this study was to determine whether gene-targeted mice that are deficient in CD11/CD18, intracellular adhesion molecule-1 (ICAM-1), or P-selectin exhibit an altered constitutive or induced expression of the endothelial cell adhesion molecules E- and P-selectin. The gene-targeted mice were all developed in the 129Sv mouse strain and backcrossed into C57Bl/6J mice. The number of backcrosses ranged between 8 (P-selectin) and 10 (CD18 and ICAM-1) generations. The dual-radiolabeled monoclonal antibody technique was used to quantify E- and P-selectin expression in different vascular beds. In the unstimulated state, E-selectin expression was significantly elevated (relative to wild-type mice) in the stomach, large intestine, and brain of mutants deficient in ICAM-1. In general, constitutive expression of P-selectin did not differ between wild-type, ICAM-1-deficient, and CD11/CD18-deficient mutants. In CD11/CD18-deficient mice, tumor necrosis factor-α (TNF-α) administration elicited a more profound upregulation of P-selectin in several vascular beds, compared with wild-type and ICAM-1-deficient mice. E-selectin expression in brain of TNF-α-stimulated, ICAM-1-deficient, and P-selectin-deficient mice was attenuated compared with wild-type mice. These findings indicate that chronic deficiency of some of the adhesion glycoproteins that mediate leukocyte recruitment alters basal and induced surface expression of other adhesion molecules on endothelial cells.

Association between Serum Carcinoembryonic Antigen and Endothelial Cell Adhesion Molecules in Colorectal Cancer

Oncology ◽  
2003 ◽  
Vol 65 (2) ◽  
pp. 132-138 ◽  
Author(s):  
Mario Roselli ◽  
Fiorella Guadagni ◽  
Francesca Martini ◽  
Antonella Spila ◽  
Sabrina Mariotti ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Cell Adhesion ◽  
Endothelial Cell ◽  
Carcinoembryonic Antigen ◽  
Adhesion Molecules ◽  
Cell Adhesion Molecules ◽  
Serum Carcinoembryonic Antigen ◽  
Endothelial Cell Adhesion Molecules ◽  
Endothelial Cell Adhesion

INFLUENCE OF DIFFERENT COLLOIDS ON THE EXPRESSION OF ENDOTHELIAL CELL ADHESION MOLECULES

Shock ◽  
1997 ◽  
Vol 7 (Supplement) ◽  
pp. 50
Author(s):  
H. J. Dieterich ◽  
B. Nohé ◽  
A. Rothmund ◽  
M. Eichner ◽  
K. Unertl
Keyword(s):  
Cell Adhesion ◽  
Endothelial Cell ◽  
Adhesion Molecules ◽  
Cell Adhesion Molecules ◽  
Endothelial Cell Adhesion Molecules ◽  
Endothelial Cell Adhesion

Effect of Linomide on adhesion molecules, TNF-α, nitrogen oxide, and cell adhesion

2005 ◽  
Vol 5 (2) ◽  
pp. 231-239 ◽  
Author(s):  
A. Abdul-Hai ◽  
R. Hershkoviz ◽  
L. Weiss ◽  
O. Lider ◽  
S. Slavin
Keyword(s):  
Cell Adhesion ◽  
Nitrogen Oxide ◽  
Adhesion Molecules ◽  
Tnf Α
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