Some pharmacological effects of an ethanolic extract ofPalisota ambigua on the central nervous system in mice

1994 ◽  
Vol 8 (7) ◽  
pp. 426-429 ◽  
Author(s):  
P. N'Gouemo ◽  
M. Baldy-Moulinier ◽  
C. Nguemby-Bina
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Ethanolic Extract ◽  
Pharmacological Effects ◽  
The Central Nervous System

Some Pharmacological Effects of an Ethanolic Extract ofTrema guineensison the Central Nervous System in Rodents

Planta Medica ◽  
1994 ◽  
Vol 60 (04) ◽  
pp. 305-307 ◽  
Author(s):  
Prosper N’Gouemo ◽  
Honorine Pambou-Tchivounda ◽  
Michel Baldy-Moulinier ◽  
Blaise Koudogbo ◽  
Célestin N'Guemby-Bina
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Ethanolic Extract ◽  
Pharmacological Effects ◽  
The Central Nervous System

A comparison of some pharmacological effects of naloxone and N-methylnaloxone in mice

1982 ◽  
Vol 60 (5) ◽  
pp. 715-719 ◽  
Author(s):  
K. Ramabadran ◽  
C. Suaudeau ◽  
J. J. C. Jacob
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Subcutaneous Administration ◽  
Intracerebroventricular Injection ◽  
Pharmacological Effects ◽  
Opioid Antagonists ◽  
Hot Plate ◽  
Two Factors ◽  
The Central Nervous System ◽  
Derivatives Of

The effects of N-methylnaloxone following subcutaneous and intracerebroventricular administrations on nociception were investigated using the hot plate technique. Unlike naloxone, subcutaneous administration of N-methylnaloxone did not enhance the nociceptive reactions. In contrast, intracerebroventricular injection of N-methylnaloxone produced antinociception and tremor. Compared with naloxone, N-methylnaloxone was very weak in precipitating the signs of abstinence in mice rendered acutely dependent on morphine. Two factors, poor penetration into the central nervous system and steric hindrance, might render N-methylnaloxone very weak and hence both these factors must be taken into consideration while analyzing the effects following quaternary derivatives of opioid antagonists.

scholarly journals Synthesis and pharmacological properties of 3-(2-methyl-furan-3-yl)-4-substituted-Δ2-1,2,4-triazoline-5-thiones

2008 ◽  
Vol 6 (1) ◽  
pp. 47-53 ◽  
Author(s):  
Agata Siwek ◽  
Monika Wujec ◽  
Maria Dobosz ◽  
Ewa Jagiełło-Wójtowicz ◽  
Anna Chodkowska ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Carboxylic Acid ◽  
Acid Hydrazide ◽  
Pharmacological Properties ◽  
Pharmacological Effects ◽  
Carboxylic Acid Hydrazide ◽  
Wide Range ◽  
The Central Nervous System

AbstractBy the reaction of 2-methyl-furan-3-carboxylic acid hydrazide with isothiocyanates, 1-[(2-methyl-furan-3-yl)carbonyl]-4-substituted thiosemicarbazides 1 were obtained. Further cyclization with 2% NaOH led to the formation of 3-(2-methyl-furan-3-yl)-4-substituted-Δ2-1,2,4-triazoline-5-thiones 2. The pharmacological effects of 2 on the central nervous system in mice were investigated. Strong antinociceptive properties of the investigated derivatives were observed in a wide range of doses.

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