The in vivo antifungal activity of the aqueous extract from Nigella sativa seeds

2003 ◽  
Vol 17 (2) ◽  
pp. 183-186 ◽  
Author(s):  
M. A. U. Khan ◽  
M. K. Ashfaq ◽  
H. S. Zuberi ◽  
M. S. Mahmood ◽  
A. H. Gilani
Keyword(s):  
Antifungal Activity ◽  
Aqueous Extract ◽  
Nigella Sativa ◽  
In Vivo Antifungal Activity

scholarly journals In Vivo Subacute Toxicity and Antidiabetic Effect of Aqueous Extract of Nigella sativa

2017 ◽  
Vol 2017 ◽  
pp. 1-13 ◽  
Author(s):  
Karima Bensiameur-Touati ◽  
Ghouti Kacimi ◽  
El-Mehdi Haffaf ◽  
Sihem Berdja ◽  
Souhila Aouichat-Bouguerra
Keyword(s):  
Aqueous Extract ◽  
Nigella Sativa ◽  
Histological Study ◽  
Diabetic Rats ◽  
Antidiabetic Effect ◽  
Subacute Toxicity ◽  
Wide Range ◽  
Liver And Pancreas ◽  
Liver Tbars

Context. Nigella sativa seeds are usually used as traditional medicine for a wide range of therapeutic purposes. Objective. To investigate the subacute toxicity of NS aqueous extract and select its lowest dose to study its antidiabetic effect. Methods. 5 AqE.NS doses (2, 6.4, 21, 33, and 60 g/Kg) were daily administered to mice by gavage. Biochemical parameters measurements and histological study of the liver and the kidney were performed after 6 weeks of supplementation. Thereafter, and after inducing diabetes by alloxan, rats were treated by 2 g/Kg of AqE.NS during 8 weeks. Metabolic parameters were measured on sera. A horizontal electrophoresis of plasmatic lipoprotein was conducted. Glycogen, total lipids, and triglycerides were measured in the liver. TBARS were evaluated on adipose tissue, liver, and pancreas. Results. AqE.NS showed no variation in urea and albumin at the 5 doses, but hepatotoxicity from 21 g/Kg was confirmed by histopathological observations of the liver. In diabetic rats, AqE.NS significantly decreased glycemia, TG, T-cholesterol, LDL-c, and TBARS and showed a restored insulinemia and a significant increase in HDL-c. Results on the liver indicated a decrease in lipids and a possible glycogenogenesis. Conclusion. AqE.NS showed its safety at low doses and its evident antihyperglycemic, antihyperlipidemic, and antioxidant effect.

scholarly journals In Vitro and In Vivo Antifungal Activity of AmBisome Compared to Conventional Amphotericin B and Fluconazole against Candida auris

2021 ◽  
Author(s):  
Janet Herrada ◽  
Ahmed Gamal ◽  
Lisa Long ◽  
Sonia P. Sanchez ◽  
Thomas S. McCormick ◽  
...  
Keyword(s):  
Antifungal Activity ◽  
Amphotericin B ◽  
Kidney Tissue ◽  
Treated Group ◽  
Untreated Group ◽  
Candida Auris ◽  
Fungal Burden ◽  
In Vivo Antifungal Activity

Antifungal activity of AmBisome against Candida auris was determined in vitro and in vivo. AmBisome showed MIC50 and MIC90 values of 1 and 2 μg/mL, respectively. Unlike conventional amphotericin B, significant in vivo efficacy was observed in the AmBisome 7.5 mg/kg -treated group in survival and reduction of kidney tissue fungal burden compared to the untreated group. Our data shows that AmBisome shows significant antifungal activity against C. auris in vitro as well as in vivo.

Synthesis, pharmacokinetics and in vivo antifungal activity of the novel water-soluble prodrugs of itraconazole analogue YL-24

2013 ◽  
Vol 24 (4) ◽  
pp. 321-324 ◽  
Author(s):  
Yu Liu ◽  
Xu-Feng Cao ◽  
Xin Liu ◽  
Yong-Bing Cao ◽  
Wen-Jing Chu ◽  
...  
Keyword(s):  
Antifungal Activity ◽  
Water Soluble ◽  
The Novel ◽  
In Vivo Antifungal Activity

The effect of Nigella sativa aqueous extract on Dientamoeba fragilis: an in vivo experimental study

2015 ◽  
Vol 8 (1) ◽  
pp. 52
Author(s):  
OmimaM Eida ◽  
AmanyM Eida ◽  
MohamedM Eida ◽  
AminaA Dessouki
Keyword(s):  
Experimental Study ◽  
Aqueous Extract ◽  
Nigella Sativa ◽  
Dientamoeba Fragilis

In vitro and in vivo antifungal activity and preliminary mechanism of cembratrien-diols against Botrytis cinerea

2020 ◽  
Vol 154 ◽  
pp. 112745
Author(s):  
Qiong Yang ◽  
Jiao Wang ◽  
Peng Zhang ◽  
Shengnan Xie ◽  
Xiaolong Yuan ◽  
...  
Keyword(s):  
Antifungal Activity ◽  
Botrytis Cinerea ◽  
In Vivo Antifungal Activity

IN VITRO AND IN VIVO ANTIFUNGAL ACTIVITY OF EIGHT MEDICINAL PLANTS AGAINST CITRUS SOUR ROT AGENT GEOTRICHUM CANDIDUM

2015 ◽  
pp. 1563-1570 ◽  
Author(s):  
Idriss Talibi ◽  
Latifa Askarne ◽  
Hassan Boubaker ◽  
El Hassane Boudyach ◽  
Abdellah Ait Ben Oumar
Keyword(s):  
Antifungal Activity ◽  
Medicinal Plants ◽  
Geotrichum Candidum ◽  
Sour Rot ◽  
Citrus Sour Rot ◽  
In Vivo Antifungal Activity

scholarly journals In vitro and in vivo antifungal activity of natural inhibitors against Penicillium expansum

2013 ◽  
Vol 33 ◽  
pp. 40-46 ◽  
Author(s):  
Claudia Fieira ◽  
Francieli Oliveira ◽  
Rubens Perez Calegari ◽  
Alessandra Machado ◽  
Alexandre Rodrigo Coelho
Keyword(s):  
Antifungal Activity ◽  
Penicillium Expansum ◽  
Natural Inhibitors ◽  
In Vivo Antifungal Activity
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