A practical comparison of blinded methods for sample size reviews in survival data clinical trials

2012 ◽  
Vol 11 (2) ◽  
pp. 141-148 ◽  
Author(s):  
Susan Todd ◽  
Elsa Valdés-Márquez ◽  
Jodie West
Keyword(s):  
Clinical Trials ◽  
Sample Size ◽  
Survival Data

Planning the Size of Clinical Trials with Allowance for Patient Noncompliance

1990 ◽  
Vol 29 (03) ◽  
pp. 243-246 ◽  
Author(s):  
M. A. A. Moussa
Keyword(s):  
Clinical Trial ◽  
Clinical Trials ◽  
Sample Size ◽  
Event Rate ◽  
Survival Functions ◽  
Time Intervals ◽  
Patient Noncompliance ◽  
Event Rates ◽  
Larger Sample

AbstractVarious approaches are considered for adjustment of clinical trial size for patient noncompliance. Such approaches either model the effect of noncompliance through comparison of two survival distributions or two simple proportions. Models that allow for variation of noncompliance and event rates between time intervals are also considered. The approach that models the noncompliance adjustment on the basis of survival functions is conservative and hence requires larger sample size. The model to be selected for noncompliance adjustment depends upon available estimates of noncompliance and event rate patterns.

scholarly journals Do patient characteristics matter when calculating sample size for eczema clinical trials?

2021 ◽  
Author(s):  
L. Howells ◽  
S. Gran ◽  
J. R. Chalmers ◽  
B. Stuart ◽  
M. Santer ◽  
...  
Keyword(s):  
Clinical Trials ◽  
Sample Size ◽  
Patient Characteristics

Sample size calculation for clinical trials in which entry criteria and outcomes are counts of events

1994 ◽  
Vol 13 (8) ◽  
pp. 859-870 ◽  
Author(s):  
Robert P. McMahon ◽  
Michael Proschan ◽  
Nancy L. Geller ◽  
Peter H. Stone ◽  
George Sopko
Keyword(s):  
Clinical Trials ◽  
Sample Size ◽  
Sample Size Calculation

scholarly journals Maximum type 1 error rate inflation in multiarmed clinical trials with adaptive interim sample size modifications

2014 ◽  
Vol 56 (4) ◽  
pp. 614-630 ◽  
Author(s):  
Alexandra C. Graf ◽  
Peter Bauer ◽  
Ekkehard Glimm ◽  
Franz Koenig
Keyword(s):  
Clinical Trials ◽  
Sample Size ◽  
Error Rate ◽  
Type 1 Error ◽  
Multiarmed Clinical Trials
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