Simultaneous confidence interval for assessing non‐inferiority with assay sensitivity in a three‐arm trial with binary endpoints

2020 ◽  
Vol 19 (5) ◽  
pp. 518-531
Author(s):  
Niansheng Tang ◽  
Bin Yu
Keyword(s):  
Confidence Interval ◽  
Assay Sensitivity ◽  
Simultaneous Confidence Interval

scholarly journals AMSM- Multivariate Inferential Statistics- Chapter Eight

2018 ◽  
Author(s):  
Mohammed R. Dahman
Keyword(s):  
Central Limit Theorem ◽  
Limit Theorem ◽  
Confidence Interval ◽  
Linear Combination ◽  
Central Limit ◽  
Confidence Region ◽  
Inferential Statistics ◽  
Single Population ◽  
Simultaneous Confidence Interval

In this chapter we discus the multivariate central limit theorem. Then in thorough the Hotelling's T-square distribution. Armed with these information we explain the inferential of single population using the confidence region and the simultaneous confidence interval with two techniques the linear combination and the Bonferroni approach. At the end we discus the hypothesis teasing.

scholarly journals A Dual-Antigen Enzyme-Linked Immunosorbent Assay Allows the Assessment of Severe Acute Respiratory Syndrome Coronavirus 2 Antibody Seroprevalence in a Low-Transmission Setting

2020 ◽  
Vol 223 (1) ◽  
pp. 10-14 ◽  
Author(s):  
Sarah M Hicks ◽  
Kai Pohl ◽  
Teresa Neeman ◽  
Hayley A McNamara ◽  
Kate M Parsons ◽  
...  
Keyword(s):  
Severe Acute Respiratory Syndrome ◽  
Confidence Interval ◽  
Sensitivity And Specificity ◽  
Immunosorbent Assay ◽  
Elective Surgery ◽  
Enzyme Linked Immunosorbent Assay ◽  
Receptor Binding Domain ◽  
Assay Sensitivity ◽  
Specific Antibodies ◽  
Transmission Setting

Abstract Estimates of seroprevalence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) antibodies have been hampered by inadequate assay sensitivity and specificity. Using an enzyme-linked immunosorbent assay–based approach that combines data about immunoglobulin G responses to both the nucleocapsid and spike receptor binding domain antigens, we show that excellent sensitivity and specificity can be achieved. We used this assay to assess the frequency of virus-specific antibodies in a cohort of elective surgery patients in Australia and estimated seroprevalence in Australia to be 0.28% (95% Confidence Interval, 0–1.15%). These data confirm the low level of transmission of SARS-CoV-2 in Australia before July 2020 and validate the specificity of our assay.

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