Quasi-localized low-frequency vibrational modes of disordered solids: Study by single-molecule spectroscopy

2004 ◽  
Vol 241 (15) ◽  
pp. 3435-3435 ◽  
Author(s):  
A. V. Naumov ◽  
Yu. G. Vainer ◽  
M. Bauer ◽  
L. Kador
Keyword(s):  
Single Molecule ◽  
Low Frequency ◽  
Vibrational Modes ◽  
Single Molecule Spectroscopy ◽  
Disordered Solids

Quasi-localized low-frequency vibrational modes of disordered solids I. Study by photon echo

2004 ◽  
Vol 241 (15) ◽  
pp. 3480-3486 ◽  
Author(s):  
Yu. G. Vainer ◽  
A. V. Naumov ◽  
M. A. Kol'chenko ◽  
R. I. Personov
Keyword(s):  
Low Frequency ◽  
Photon Echo ◽  
Vibrational Modes ◽  
Disordered Solids

scholarly journals Low frequency vibrational modes of oxygenated myoglobin, hemoglobins, and modified derivatives.

1994 ◽  
Vol 269 (49) ◽  
pp. 31047-31050
Author(s):  
S Jeyarajah ◽  
L M Proniewicz ◽  
H Bronder ◽  
J R Kincaid
Keyword(s):  
Low Frequency ◽  
Vibrational Modes

scholarly journals A role for the fusogen eff-1 in epidermal stem cell number robustness in Caenorhabditis elegans

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Sneha L. Koneru ◽  
Fu Xiang Quah ◽  
Ritobrata Ghose ◽  
Mark Hintze ◽  
Nicola Gritti ◽  
...  
Keyword(s):  
Stem Cell ◽  
Caenorhabditis Elegans ◽  
Cell Fate ◽  
Single Molecule ◽  
Phenotypic Variability ◽  
Low Frequency ◽  
Time Lapse ◽  
Cell Number ◽  
Seam Cell ◽  
Neuronal Tissues

AbstractDevelopmental patterning in Caenorhabditis elegans is known to proceed in a highly stereotypical manner, which raises the question of how developmental robustness is achieved despite the inevitable stochastic noise. We focus here on a population of epidermal cells, the seam cells, which show stem cell-like behaviour and divide symmetrically and asymmetrically over post-embryonic development to generate epidermal and neuronal tissues. We have conducted a mutagenesis screen to identify mutants that introduce phenotypic variability in the normally invariant seam cell population. We report here that a null mutation in the fusogen eff-1 increases seam cell number variability. Using time-lapse microscopy and single molecule fluorescence hybridisation, we find that seam cell division and differentiation patterns are mostly unperturbed in eff-1 mutants, indicating that cell fusion is uncoupled from the cell differentiation programme. Nevertheless, seam cell losses due to the inappropriate differentiation of both daughter cells following division, as well as seam cell gains through symmetric divisions towards the seam cell fate were observed at low frequency. We show that these stochastic errors likely arise through accumulation of defects interrupting the continuity of the seam and changing seam cell shape, highlighting the role of tissue homeostasis in suppressing phenotypic variability during development.

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