Quantitative Systems Pharmacology
            and
            Physiologically‐Based Pharmacokinetic
            Modeling With mrgsolve: A Hands‐On Tutorial

Ahmed Elmokadem; Matthew M. Riggs; Kyle T. Baron

doi:10.1002/psp4.12467

Quantitative Systems Pharmacology and Physiologically‐Based Pharmacokinetic Modeling With mrgsolve: A Hands‐On Tutorial

CPT Pharmacometrics & Systems Pharmacology ◽

10.1002/psp4.12467 ◽

2019 ◽

Vol 8 (12) ◽

pp. 883-893 ◽

Cited By ~ 5

Author(s):

Ahmed Elmokadem ◽

Matthew M. Riggs ◽

Kyle T. Baron

Keyword(s):

Pharmacokinetic Modeling ◽

Systems Pharmacology ◽

Physiologically Based Pharmacokinetic Modeling ◽

Quantitative Systems Pharmacology ◽

Physiologically Based Pharmacokinetic ◽

Hands On ◽

Physiologically Based

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Data Digitizing: Accurate and Precise Data Extraction for Quantitative Systems Pharmacology and Physiologically‐Based Pharmacokinetic Modeling

CPT Pharmacometrics & Systems Pharmacology ◽

10.1002/psp4.12511 ◽

2020 ◽

Vol 9 (6) ◽

pp. 322-331 ◽

Cited By ~ 8

Author(s):

Jan‐Georg Wojtyniak ◽

Hannah Britz ◽

Dominik Selzer ◽

Matthias Schwab ◽

Thorsten Lehr

Keyword(s):

Data Extraction ◽

Pharmacokinetic Modeling ◽

Systems Pharmacology ◽

Physiologically Based Pharmacokinetic Modeling ◽

Quantitative Systems Pharmacology ◽

Precise Data ◽

Physiologically Based Pharmacokinetic ◽

Physiologically Based

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Pain Chemogenomics Knowledgebase (Pain-CKB) for Systems Pharmacology Target Mapping and Physiologically Based Pharmacokinetic Modeling Investigation of Opioid Drug–Drug Interactions

ACS Chemical Neuroscience ◽

10.1021/acschemneuro.0c00372 ◽

2020 ◽

Vol 11 (20) ◽

pp. 3245-3258

Author(s):

Mingzhe Shen ◽

Maozi Chen ◽

Tianjian Liang ◽

Siyi Wang ◽

Ying Xue ◽

...

Keyword(s):

Drug Interactions ◽

Pharmacokinetic Modeling ◽

Systems Pharmacology ◽

Physiologically Based Pharmacokinetic Modeling ◽

Physiologically Based Pharmacokinetic ◽

Physiologically Based

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Physiologically-based pharmacokinetic modeling of different size polyethylene glycol-coated gold nanoparticles in mice

10.1615/ihtc16.nmt.023362 ◽

2018 ◽

Author(s):

Linjing Deng ◽

Jinping Zhao ◽

Yufeng Miao ◽

Xu Hu ◽

Qihong Deng

Keyword(s):

Gold Nanoparticles ◽

Polyethylene Glycol ◽

Pharmacokinetic Modeling ◽

Physiologically Based Pharmacokinetic Modeling ◽

Physiologically Based Pharmacokinetic ◽

Physiologically Based

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Physiologically-Based Pharmacokinetic Modeling to Predict Changes in Drug Exposure during Pregnancy Using the Simcyp Simulator

10.26226/morressier.57d6b2b7d462b8028d88e945 ◽

2016 ◽

Author(s):

Suvarchala Kiranmai Avvari

Keyword(s):

Drug Exposure ◽

Pharmacokinetic Modeling ◽

Physiologically Based Pharmacokinetic Modeling ◽

Physiologically Based Pharmacokinetic ◽

Physiologically Based ◽

Exposure During Pregnancy

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Physiologically‐Based Pharmacokinetic Modeling of Atorvastatin Incorporating Delayed Gastric Emptying and Acid‐to‐Lactone Conversion

CPT Pharmacometrics & Systems Pharmacology ◽

10.1002/psp4.12447 ◽

2019 ◽

Vol 8 (9) ◽

pp. 664-675 ◽

Cited By ~ 5

Author(s):

Bridget L. Morse ◽

Jeffrey J. Alberts ◽

Maria M. Posada ◽

Jessica Rehmel ◽

Anil Kolur ◽

...

Keyword(s):

Gastric Emptying ◽

Delayed Gastric Emptying ◽

Pharmacokinetic Modeling ◽

Physiologically Based Pharmacokinetic Modeling ◽

Physiologically Based Pharmacokinetic ◽

Physiologically Based

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Preliminary physiologically based pharmacokinetic modeling of renally cleared drugs in Chinese pregnant women

Biopharmaceutics & Drug Disposition ◽

10.1002/bdd.2243 ◽

2020 ◽

Vol 41 (6) ◽

pp. 248-267 ◽

Cited By ~ 1

Author(s):

Ling Song ◽

Zhiheng Yu ◽

Yifan Xu ◽

Xiaobei Li ◽

Xuanlin Liu ◽

...

Keyword(s):

Pregnant Women ◽

Pharmacokinetic Modeling ◽

Physiologically Based Pharmacokinetic Modeling ◽

Physiologically Based Pharmacokinetic ◽

Physiologically Based

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Prediction of fluoxetine and norfluoxetine pharmacokinetic profiles using physiologically based pharmacokinetic modeling

The Journal of Clinical Pharmacology ◽

10.1002/jcph.1927 ◽

2021 ◽

Author(s):

Hyeon‐Cheol Jeong ◽

Yoon‐Jee Chae ◽

Sooyeun Lee ◽

Wonku Kang ◽

Hwi‐yeol Yun ◽

...

Keyword(s):

Pharmacokinetic Modeling ◽

Physiologically Based Pharmacokinetic Modeling ◽

Physiologically Based Pharmacokinetic ◽

Pharmacokinetic Profiles ◽

Physiologically Based

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Physiologically Based Pharmacokinetic Modeling Approach to Predict Drug‐Drug Interactions With Ethionamide Involving Impact of Genetic Polymorphism on FMO3

The Journal of Clinical Pharmacology ◽

10.1002/jcph.1378 ◽

2019 ◽

Vol 59 (6) ◽

pp. 880-889 ◽

Cited By ~ 1

Author(s):

Phuong Thi Thu Nguyen ◽

Md Masud Parvez ◽

Min Jung Kim ◽

Sung Eun Yoo ◽

Sangzin Ahn ◽

...

Keyword(s):

Genetic Polymorphism ◽

Drug Interactions ◽

Pharmacokinetic Modeling ◽

Physiologically Based Pharmacokinetic Modeling ◽

Modeling Approach ◽

Physiologically Based Pharmacokinetic ◽

Physiologically Based

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Physiologically Based Pharmacokinetic Modeling and Tissue Distribution Characteristics of SHetA2 in Tumor-Bearing Mice

The AAPS Journal ◽

10.1208/s12248-020-0421-z ◽

2020 ◽

Vol 22 (2) ◽

Author(s):

Ankur Sharma ◽

Mengjie Li ◽

Elangovan Thavathiru ◽

Mariam Ibrahim ◽

Lucila Garcia-Contreras ◽

...

Keyword(s):

Tissue Distribution ◽

Pharmacokinetic Modeling ◽

Distribution Characteristics ◽

Physiologically Based Pharmacokinetic Modeling ◽

Tumor Bearing ◽

Physiologically Based Pharmacokinetic ◽

Physiologically Based

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Physiologically Based Pharmacokinetic Modeling of the Temperature-Dependent Dermal Absorption of Chloroform by Humans following Bath Water Exposures

Toxicological Sciences ◽

10.1093/toxsci/53.1.13 ◽

2000 ◽

Vol 53 (1) ◽

pp. 13-23 ◽

Cited By ~ 50

Author(s):

R. A. Corley

Keyword(s):

Pharmacokinetic Modeling ◽

Dermal Absorption ◽

Physiologically Based Pharmacokinetic Modeling ◽

Temperature Dependent ◽

Physiologically Based Pharmacokinetic ◽

Physiologically Based ◽

Bath Water

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