scholarly journals Evaluating the Role of Janus Kinase Pathways in Platelet Homeostasis Using a Systems Modeling Approach

2019 ◽  
Vol 8 (7) ◽  
pp. 478-488 ◽  
Author(s):  
Sarita Koride ◽  
Satyaprakash Nayak ◽  
Christopher Banfield ◽  
Mark C. Peterson
Keyword(s):  
Janus Kinase ◽  
Systems Modeling ◽  
Modeling Approach

scholarly journals A Systems Modeling Approach to Forecast Corn Economic Optimum Nitrogen Rate

2018 ◽  
Vol 9 ◽  
Author(s):  
Laila A. Puntel ◽  
John E. Sawyer ◽  
Daniel W. Barker ◽  
Peter J. Thorburn ◽  
Michael J. Castellano ◽  
...  
Keyword(s):  
Systems Modeling ◽  
Nitrogen Rate ◽  
Modeling Approach

scholarly journals The role of ICEVs, HEVs, PHEVs, BEVs and FCVs in achieving stringent CO2 targets: results from global energy systems modeling

2009 ◽  
Vol 3 (3) ◽  
pp. 519-530 ◽  
Author(s):  
Maria Grahn ◽  
James. E. Anderson ◽  
Timothy. J. Wallington ◽  
Mats Williander
Keyword(s):  
Energy Systems ◽  
Systems Modeling ◽  
Global Energy

scholarly journals JAK/STAT Activation: A General Mechanism for Bone Development, Homeostasis, and Regeneration

2020 ◽  
Vol 21 (23) ◽  
pp. 9004
Author(s):  
Alexandra Damerau ◽  
Timo Gaber ◽  
Sarah Ohrndorf ◽  
Paula Hoff
Keyword(s):  
Signaling Pathway ◽  
Bone Development ◽  
Gene Knockout ◽  
Selective Inhibition ◽  
Janus Kinase ◽  
General Mechanism ◽  
Stat Signaling ◽  
Skeletal Phenotype ◽  
Pro Inflammatory Cytokines

The Janus kinase (JAK) signal transducer and activator of transcription (STAT) signaling pathway serves as an important downstream mediator for a variety of cytokines, hormones, and growth factors. Emerging evidence suggests JAK/STAT signaling pathway plays an important role in bone development, metabolism, and healing. In this light, pro-inflammatory cytokines are now clearly implicated in these processes as they can perturb normal bone remodeling through their action on osteoclasts and osteoblasts at both intra- and extra-articular skeletal sites. Here, we summarize the role of JAK/STAT pathway on development, homeostasis, and regeneration based on skeletal phenotype of individual JAK and STAT gene knockout models and selective inhibition of components of the JAK/STAT signaling including influences of JAK inhibition in osteoclasts, osteoblasts, and osteocytes.

Management of refractory cutaneous dermatomyositis: potential role of Janus kinase inhibition with tofacitinib

Rheumatology ◽  
2019 ◽  
Vol 58 (6) ◽  
pp. 1011-1015 ◽  
Author(s):  
Siamak Moghadam-Kia ◽  
Devon Charlton ◽  
Rohit Aggarwal ◽  
Chester V Oddis
Keyword(s):  
Potential Role ◽  
Janus Kinase ◽  
Kinase Inhibition ◽  
Janus Kinase Inhibition
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