scholarly journals A Novel PBPK Modeling Approach to Assess Cytochrome P450 Mediated Drug-Drug Interaction Potential of the Cytotoxic Prodrug Evofosfamide

2018 ◽  
Vol 7 (12) ◽  
pp. 829-837 ◽  
Author(s):  
Christian Lüpfert ◽  
Martin Dyroff ◽  
Oliver von Richter ◽  
Dieter Gallemann ◽  
Samer El Bawab ◽  
...  
Keyword(s):  
Cytochrome P450 ◽  
Drug Interaction ◽  
Interaction Potential ◽  
Pbpk Modeling ◽  
Modeling Approach ◽  
Drug Drug Interaction

Use of Multiple Probes to Assess Transporter- and Cytochrome P450-Mediated Drug–Drug Interaction Potential of the Pangenotypic HCV NS5A Inhibitor Velpatasvir

2015 ◽  
Vol 55 (5) ◽  
pp. 605-613 ◽  
Author(s):  
Erik Mogalian ◽  
Polina German ◽  
Brian P. Kearney ◽  
Cheng Yong Yang ◽  
Diana Brainard ◽  
...  
Keyword(s):  
Cytochrome P450 ◽  
Drug Interaction ◽  
Interaction Potential ◽  
Ns5a Inhibitor ◽  
Drug Drug Interaction

Cyclosporine Inhibition of Hepatic and Intestinal CYP3A4, Uptake and Efflux Transporters: Application of PBPK Modeling in the Assessment of Drug-Drug Interaction Potential

2012 ◽  
Vol 30 (3) ◽  
pp. 761-780 ◽  
Author(s):  
Michael Gertz ◽  
Catherine M. Cartwright ◽  
Michael J. Hobbs ◽  
Kathryn E. Kenworthy ◽  
Malcolm Rowland ◽  
...  
Keyword(s):  
Drug Interaction ◽  
Interaction Potential ◽  
Pbpk Modeling ◽  
Efflux Transporters ◽  
Drug Drug Interaction
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