scholarly journals Tissue‐Specific Analysis of Pharmacological Pathways

2018 ◽  
Vol 7 (7) ◽  
pp. 453-463 ◽  
Author(s):  
Yun Hao ◽  
Kayla Quinnies ◽  
Ronald Realubit ◽  
Charles Karan ◽  
Nicholas P. Tatonetti
Keyword(s):  
Tissue Specific ◽  
Specific Analysis

Mechanisms of glycolytic control during facultative anaerobiosis in a marine mollusc: tissue-specific analysis of glycogen phosphorylase and fructose-2,6-bisphosphate

1988 ◽  
Vol 66 (8) ◽  
pp. 1767-1771 ◽  
Author(s):  
Kenneth B. Storey
Keyword(s):  
Glycogen Phosphorylase ◽  
Retractor Muscle ◽  
Dramatic Reduction ◽  
Metabolic Rate Depression ◽  
Tissue Specific ◽  
Marine Mollusc ◽  
Energy Needs ◽  
Specific Analysis ◽  
Anaerobic Energy ◽  
Glycolytic Control

Changes in the activity of glycogen phosphorylase and the content of fructose-2,6-bisphosphate (F-2, 6-P2) were monitored in tissues of the whelk, Busycotypus canaliculatum, over a 21-h course of environmental anoxia. Tissue-specific responses to anoxia were seen with respect to phosphorylase content: in the radular retractor muscle and foot, the content of phosphorylase a expressed rose rapidly over the initial hours of anoxia (maximal increases were 4.3- and 2.5-fold, respectively) while in the gill, content dropped 2-fold during anoxia. Phosphorylase content was modulated by two mechanisms, changes in the percentage of enzyme in the active a form and changes in the total amount (a + b) of enzyme expressed. Anoxia stimulated a dramatic reduction in F-2,6-P2 content in five tissues. In the ventricle, content fell by 224-fold with a t1/2 of only 35 min. Levels in gill, radular retractor, hepatopancreas, and kidney fell to 2.5–3.5% of control values within the first 8 h of anoxia. F-2,6-P2 content in foot muscle was not altered during anoxia. Changes in glycogen phosphorylase activities and F-2,6-P2 contents help to produce tissue-specific responses of glycolysis to environmental anoxia that acknowledge competing metabolic demands including metabolic rate depression, changes in fuel use, anaerobic energy needs, and carbohydrate use for anabolic purposes.

Tissue specific analysis of bioconversion traits in the bioenergy grass Sorghum bicolor

2013 ◽  
Vol 50 ◽  
pp. 118-130 ◽  
Author(s):  
Joshua P. Vandenbrink ◽  
Ryan E. Hammonds ◽  
Roger N. Hilten ◽  
K.C. Das ◽  
J. Michael Henson ◽  
...  
Keyword(s):  
Sorghum Bicolor ◽  
Tissue Specific ◽  
Specific Analysis

scholarly journals A unique mouse strain expressing Cre recombinase for tissue-specific analysis of gene function in palate and kidney development

genesis ◽  
2007 ◽  
Vol 45 (10) ◽  
pp. 618-624 ◽  
Author(s):  
Yu Lan ◽  
Qingru Wang ◽  
Catherine E. Ovitt ◽  
Rulang Jiang
Keyword(s):  
Gene Function ◽  
Mouse Strain ◽  
Kidney Development ◽  
Cre Recombinase ◽  
Tissue Specific ◽  
Specific Analysis

Preparative laser capture microdissection and single-pot cell wall material preparation: a novel method for tissue-specific analysis

Planta ◽  
2006 ◽  
Vol 224 (1) ◽  
pp. 228-232 ◽  
Author(s):  
Guillermo Angeles ◽  
Jimmy Berrio-Sierra ◽  
Jean-Paul Joseleau ◽  
Philippe Lorimier ◽  
Andrée Lefèbvre ◽  
...  
Keyword(s):  
Cell Wall ◽  
Laser Capture Microdissection ◽  
Wall Material ◽  
Cell Wall Material ◽  
Tissue Specific ◽  
Specific Analysis ◽  
Novel Method ◽  
Laser Capture ◽  
Material Preparation

Species and tissue specific analysis based on quantitative proteomics from allotetraploid and the parents

2021 ◽  
Vol 232 ◽  
pp. 104073
Author(s):  
Xiaoping Dong ◽  
Yujie Yan ◽  
Ping Chen ◽  
Chun Zhang ◽  
Li Ren ◽  
...  
Keyword(s):  
Quantitative Proteomics ◽  
Tissue Specific ◽  
Specific Analysis

scholarly journals MR Perfusion and Diffusion in Acute Ischemic Stroke: Human Gray and White Matter have Different Thresholds for Infarction

2005 ◽  
Vol 25 (10) ◽  
pp. 1280-1287 ◽  
Author(s):  
Michael S Bristow ◽  
Jessica E Simon ◽  
Robert A Brown ◽  
Michael Eliasziw ◽  
Michael D Hill ◽  
...  
Keyword(s):  
At Risk ◽  
Ischemic Stroke ◽  
White Matter ◽  
Acute Ischemic Stroke ◽  
Cerebral Blood Volume ◽  
Mean Transit Time ◽  
Mr Perfusion ◽  
Tissue Specific ◽  
Specific Analysis ◽  
And Diffusion

It is thought that gray and white matter (GM and WM) have different perfusion and diffusion thresholds for cerebral infarction in humans. We sought to determine these thresholds with voxel-by-voxel, tissue-specific analysis of coregistered acute and follow-up magnetic resonance (MR) perfusion- and diffusion-weighted imaging. Quantitative cerebral blood flow (CBF), cerebral blood volume (CBV), mean transit time (MTT), and apparent diffusion coefficient (ADC) maps were analyzed from nine acute stroke patients (imaging acquired within 6 h of onset). The average values of each measure were calculated for GM and WM in normally perfused tissue, the region of recovered tissue and in the final infarct. Perfusion and diffusion thresholds for infarction were determined on a patient-by-patient basis in GM and WM separately by selecting thresholds with equal sensitivities and specificities. Gray matter has higher thresholds for infarction than WM ( P<0.009) for CBF (20.0 mL/100 g min in GM and 12.3 mL/100 g min in WM), CBV (2.4 mL/100 g in GM and 1.7 mL/100 g in WM), and ADC (786 × 10−6 mm2/s in GM and 708 × 10−6 mm2/s in WM). The MTT threshold for infarction in GM is lower ( P = 0.014) than for WM (6.8 secs in GM and 7.1 secs in WM). A single common threshold applied to both tissues overestimates tissue at risk in WM and underestimates tissue at risk in GM. This study suggests that tissue-specific analysis of perfusion and diffusion imaging is required to accurately predict tissue at risk of infarction in acute ischemic stroke.

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