scholarly journals Application of a Systems Pharmacology‐Based Placebo Population Model to Analyze Long‐Term Data of Postmenopausal Osteoporosis

2015 ◽  
Vol 4 (9) ◽  
pp. 516-526 ◽  
Author(s):  
J Berkhout ◽  
JA Stone ◽  
KM Verhamme ◽  
BH Stricker ◽  
MC Sturkenboom ◽  
...  
Keyword(s):  
Postmenopausal Osteoporosis ◽  
Population Model ◽  
Systems Pharmacology ◽  
Term Data

Hydrogeological responses in tropical mountainous springs

2019 ◽  
Author(s):  
Ricardo Sánchez-Murillo
Keyword(s):  
Costa Rica ◽  
Isotope Composition ◽  
Central Valley ◽  
Distribution Functions ◽  
Geochemical Composition ◽  
Transit Times ◽  
Management Plans ◽  
Best Fit ◽  
Term Data

This study presents a hydrogeochemical analysis of spring responses (2013-2017) in the tropical mountainous region of the Central Valley of Costa Rica. The isotopic distribution of δ18O and δ2H in rainfall resulted in a highly significant meteoric water line: δ2H = 7.93×δ18O + 10.37 (r2=0.97). Rainfall isotope composition exhibited a strong dependent seasonality. The isotopic variation (δ18O) of two springs within the Barva aquifer was simulated using the FlowPC program to determine mean transit times (MTTs). Exponential-piston and dispersion distribution functions provided the best-fit to the observed isotopic composition at Flores and Sacramento springs, respectively. MTTs corresponded to 1.23±0.03 (Sacramento) and 1.42±0.04 (Flores) years. The greater MTT was represented by a homogeneous geochemical composition at Flores, whereas the smaller MTT at Sacramento is reflected in a more variable geochemical response. The results may be used to enhance modelling efforts in central Costa Rica, whereby scarcity of long-term data limits water resources management plans.

Morphometric studies of artemia males from different populations of the Altai region

2020 ◽  
pp. 28-38
Author(s):  
L. Vesnina ◽  
G. Lukerina ◽  
T. Ronzhina ◽  
A. Savos’kin ◽  
D. Surkov
Keyword(s):  
Sexual Dimorphism ◽  
Hydrogen Index ◽  
Morphometric Parameters ◽  
Altai Region ◽  
Sexual Structure ◽  
Different Populations ◽  
Artemia Population ◽  
Term Data ◽  
Brine Salinity

The long-term data from morphometric studies of Artemia males from bisexual and parthenogenetic populations from hyperhaline reservoirs of the Altai region (Bolshoe Yarovoe Lake, Maloe Shklo Lake, and the Tanatar Lakes system) is analyzed in this paper. The description of signs of sexual dimorphism and sexual structure in different populations is given. The influence of brine salinity and hydrogen index on morphometric parameters of males was analyzed. There are differences in the sexual structure of the Artemia population: in the lakes Maloe Shklo and the thanatar system, the populations are bisexual (the share of males is 28.5 — 75.0 %), in the lake Bolshoe yarovoe — parthenogenetic (the share of males on average does not exceed 3 %). At the same time, sexual dimorphism is typical for both types of populations: females are larger than males, males have a larger head (the distance between the eyes is greater by 15.5 %, the diameter of the eye is 26.1 %, the length of the antenna is 22.3 %) and a larger number of bristles (36.1 %). The greatest variability is observed in the parameters of the Furka structure associated with the salinity of water by feedback and the pH — line indicator. Significant differences between the samples of males were revealed. The largest number of significant differences in morphometric indicators was found between samples of males from bisexual populations (lake thanatar and lake Maloe Shklo), the smallest — between males from the parthenogenetic population of lake Bolshoe yarovoe and males from lake Maloe Shklo.

Diel, lunar and seasonal vertical migration in the deep western Gulf of Mexico evidenced from a long-term data series of acoustic backscatter

2021 ◽  
pp. 102562
Author(s):  
Laura Ursella ◽  
Sara Pensieri ◽  
Enric Pallàs-Sanz ◽  
Sharon Z. Herzka ◽  
Roberto Bozzano ◽  
...  
Keyword(s):  
Gulf Of Mexico ◽  
Vertical Migration ◽  
Acoustic Backscatter ◽  
Data Series ◽  
Term Data

scholarly journals Chances and challenges of a long-term data repository in multiple sclerosis: 20th birthday of the German MS registry

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Lisa-Marie Ohle ◽  
David Ellenberger ◽  
Peter Flachenecker ◽  
Tim Friede ◽  
Judith Haas ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Sociodemographic Factors ◽  
Healthcare Research ◽  
Structure Design ◽  
Data Repository ◽  
Research Projects ◽  
Real World Data ◽  
Data Repositories ◽  
Term Data

AbstractIn 2001, the German Multiple Sclerosis Society, facing lack of data, founded the German MS Registry (GMSR) as a long-term data repository for MS healthcare research. By the establishment of a network of participating neurological centres of different healthcare sectors across Germany, GMSR provides observational real-world data on long-term disease progression, sociodemographic factors, treatment and the healthcare status of people with MS. This paper aims to illustrate the framework of the GMSR. Structure, design and data quality processes as well as collaborations of the GMSR are presented. The registry’s dataset, status and results are discussed. As of 08 January 2021, 187 centres from different healthcare sectors participate in the GMSR. Following its infrastructure and dataset specification upgrades in 2014, more than 196,000 visits have been recorded relating to more than 33,000 persons with MS (PwMS). The GMSR enables monitoring of PwMS in Germany, supports scientific research projects, and collaborates with national and international MS data repositories and initiatives. With its recent pharmacovigilance extension, it aligns with EMA recommendations and helps to ensure early detection of therapy-related safety signals.

scholarly journals 169 Secukinumab provides sustained reduction in fatigue in patients with active psoriatic arthritis through three years: long-term data from the FUTURE 1 and FUTURE 2 studies

Rheumatology ◽  
2018 ◽  
Vol 57 (suppl_3) ◽  
Author(s):  
Hector Chinoy ◽  
Laure Gossec ◽  
Tore K Kvien ◽  
Philip G Conaghan ◽  
Mikkel Østergaard ◽  
...  
Keyword(s):  
Psoriatic Arthritis ◽  
Sustained Reduction ◽  
The Future ◽  
Future 2 ◽  
Term Data

scholarly journals Classifying Data to Reduce Long-Term Data Movement in Shingled Write Disks

2016 ◽  
Vol 12 (1) ◽  
pp. 1-17 ◽  
Author(s):  
Stephanie N. Jones ◽  
Ahmed Amer ◽  
Ethan L. Miller ◽  
Darrell D. E. Long ◽  
Rekha Pitchumani ◽  
...  
Keyword(s):  
Data Movement ◽  
Term Data

Long-term data indicates that supplementary food enhances the number of breeding pairs in a Cape Vulture Gyps coprotheres colony

2016 ◽  
Vol 27 (1) ◽  
pp. 140-152 ◽  
Author(s):  
DANA G. SCHABO ◽  
SONJA HEUNER ◽  
MICHAEL V. NEETHLING ◽  
SASCHA RÖSNER ◽  
ROGER UYS ◽  
...  
Keyword(s):  
Population Dynamics ◽  
Breeding Success ◽  
Food Sources ◽  
Breeding Colony ◽  
Supplementary Food ◽  
Adequate Food ◽  
Vulture Conservation ◽  
Positive Effect ◽  
Term Data

SummaryThe number of vultures is declining in many parts of the world due to numerous threats, such as poisoning and collisions with power-lines as well as the lack of adequate food sources. Vulture restaurants, i.e. supplementary feeding stations, have become a widespread conservation tool aimed at supporting vulture colonies. However, it is poorly understood how vulture restaurants influence population dynamics and whether they affect breeding success of vulture populations. We used a 12-year dataset from a breeding colony of the Cape Vulture Gyps coprotheres and a nearby vulture restaurant in South Africa to investigate the effect of supplementary food on population dynamics and breeding success. We found a significantly positive effect of supplementary food during the nest-building stage on the number of breeding pairs. However, breeding success, i.e. the proportion of successful nests, did not depend on supplementary food during the incubation and rearing stage. Especially during the critical rearing stage, the amount of food supplied might not have been sufficient to meet food demands of the colony. Still, our results indicate that carefully managed vulture restaurants might stabilise vulture colonies and can therefore aid vulture conservation.

Sign in / Sign up

Export Citation Format

Share Document