scholarly journals Modeling Suggests a Mechanism of Synergy Between Hepatitis C Virus Entry Inhibitors and Drugs of Other Classes

2015 ◽  
Vol 4 (8) ◽  
pp. 445-453 ◽  
Author(s):  
P Padmanabhan ◽  
NM Dixit
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Virus Entry ◽  
Entry Inhibitors ◽  
Virus Entry Inhibitors

scholarly journals Reply to Padmanabhan and Dixit: Hepatitis C virus entry inhibitors for optimally boosting direct-acting antiviral-based treatments

2017 ◽  
Vol 114 (23) ◽  
pp. E4527-E4529 ◽  
Author(s):  
Hirofumi Ohashi ◽  
Yoshiki Koizumi ◽  
Kento Fukano ◽  
Takaji Wakita ◽  
Alan S. Perelson ◽  
...  
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Virus Entry ◽  
Direct Acting Antiviral ◽  
Entry Inhibitors ◽  
Virus Entry Inhibitors ◽  
Direct Acting

Identification of a series of 1,3,4-trisubstituted pyrazoles as novel hepatitis C virus entry inhibitors

2013 ◽  
Vol 23 (23) ◽  
pp. 6467-6473 ◽  
Author(s):  
Jong Yeon Hwang ◽  
Hee-Young Kim ◽  
Dong-Sik Park ◽  
Jihyun Choi ◽  
Sung Min Baek ◽  
...  
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Virus Entry ◽  
Entry Inhibitors ◽  
Virus Entry Inhibitors

Lamiridosins, Hepatitis C Virus Entry Inhibitors fromLamium album

2009 ◽  
Vol 72 (12) ◽  
pp. 2158-2162 ◽  
Author(s):  
Hongjie Zhang ◽  
Katharina Rothwangl ◽  
Andrew D. Mesecar ◽  
Ali Sabahi ◽  
Lijun Rong ◽  
...  
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Virus Entry ◽  
Entry Inhibitors ◽  
Virus Entry Inhibitors

Discovery of highly potent small molecule Hepatitis C Virus entry inhibitors

2011 ◽  
Vol 21 (22) ◽  
pp. 6852-6855 ◽  
Author(s):  
Gopi Kumar Mittapalli ◽  
Andrew Jackson ◽  
Fang Zhao ◽  
Haekyung Lee ◽  
Stephine Chow ◽  
...  
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Small Molecule ◽  
Virus Entry ◽  
Entry Inhibitors ◽  
Virus Entry Inhibitors

scholarly journals Thiophen urea derivatives as a new class of hepatitis C virus entry inhibitors

2021 ◽  
Vol 36 (1) ◽  
pp. 462-468
Author(s):  
Hyung Chul Ryu ◽  
Marc Windisch ◽  
Jee Woong Lim ◽  
Inhee Choi ◽  
Eun Kyu Lee ◽  
...  
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Virus Entry ◽  
Urea Derivatives ◽  
Entry Inhibitors ◽  
New Class ◽  
Virus Entry Inhibitors

scholarly journals Hepatitis C Virus Entry: An Intriguingly Complex and Highly Regulated Process

2020 ◽  
Vol 21 (6) ◽  
pp. 2091 ◽  
Author(s):  
Che Colpitts ◽  
Pei-Ling Tsai ◽  
Mirjam Zeisel
Keyword(s):  
Chronic Hepatitis ◽  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Viral Entry ◽  
Chronic Infection ◽  
Molecular Mechanisms ◽  
Therapeutic Potential ◽  
Virus Entry ◽  
Host Factors ◽  
Entry Inhibitors

Hepatitis C virus (HCV) is a major cause of chronic hepatitis and liver disease worldwide. Its tissue and species tropism are largely defined by the viral entry process that is required for subsequent productive viral infection and establishment of chronic infection. This review provides an overview of the viral and host factors involved in HCV entry into hepatocytes, summarizes our understanding of the molecular mechanisms governing this process and highlights the therapeutic potential of host-targeting entry inhibitors.

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