Substance P analogs containing α,α-dialkylated amino acids with potent anticancer activity

2007 ◽  
Vol 13 (8) ◽  
pp. 544-548 ◽  
Author(s):  
Sudhanand Prasad ◽  
Archna Mathur ◽  
Manu Jaggi ◽  
Anu T. Singh ◽  
Rama Mukherjee
Keyword(s):  
Amino Acids ◽  
Substance P ◽  
Anticancer Activity ◽  
Substance P Analogs

Synthesis and structural characterization of substance P analogs containing a fluoroolefin peptide bond mimic

Peptides ◽  
1992 ◽  
pp. 161-162
Author(s):  
E. Felder ◽  
T. Allmendinger ◽  
H. Fritz ◽  
E. Hungerbühler ◽  
M. Keller
Keyword(s):  
Substance P ◽  
Structural Characterization ◽  
Peptide Bond ◽  
Substance P Analogs

Central sensitization following intradermal injection of capsaicin

1997 ◽  
Vol 20 (3) ◽  
pp. 471-471 ◽  
Author(s):  
William D. Willis
Keyword(s):  
Amino Acids ◽  
Substance P ◽  
Central Sensitization ◽  
Mechanical Allodynia ◽  
Excitatory Amino Acids ◽  
Intradermal Injection ◽  
Mechanical Hyperalgesia ◽  
Spinothalamic Tract ◽  
Nociceptive Neurons ◽  
Primary Hyperalgesia

Intradermal capsaicin in humans causes pain, primary hyperalgesia, and secondary mechanical hyperalgesia and allodynia. Parallel changes occur in the responses of primate spinothalamic tract cells and in rat behavior. Neurotransmitters that trigger secondary mechanical hyperalgesia and allodynia include excitatory amino acids and substance P. Secondary mechanical allodynia is actively maintained by central mechanisms. Our group has investigated mechanisms of central sensitization of nociceptive neurons by examining the responses to intradermal injection of capsaicin. These experiments are pertinent to issues raised by coderre & katz (sect. 2).

Systematic study of substance P analogs

2009 ◽  
Vol 42 (4) ◽  
pp. 384-391 ◽  
Author(s):  
JIAN-XIN WANG ◽  
ANDREW M. BRAY ◽  
ANGELA J. DIPASQUALE ◽  
N. JOE MAEJI ◽  
H. MARIO GEYSEN
Keyword(s):  
Substance P ◽  
Systematic Study ◽  
Substance P Analogs

scholarly journals Transmitters Involved in Central Processing of Nociceptive Information

1982 ◽  
Vol 10 (2) ◽  
pp. 133-138 ◽  
Author(s):  
Arthur W. Duggan
Keyword(s):  
Amino Acids ◽  
Substance P ◽  
Primary Afferents ◽  
Aminobutyric Acid ◽  
Membrane Properties ◽  
Central Processing ◽  
Nociceptive Information ◽  
Nociceptive Afferents ◽  
Distribution Studies ◽  
Dorsal Horn Neurones

Distribution studies suggest that substance P is a transmitter released by nociceptive primary afferent fibres. Acceptance of this role, however, needs more electro-physiological comparisons of the effects of substance P and the transmitter released by primary afferents on the membrane properties of dorsal horn neurones. The transmission of impulses from nociceptive afferents to supraspinal areas is subject to inhibition of both segmental and supraspinal origin. Segmental inhibition probably involves glycine and γ-aminobutyric acid as transmitters. Of supraspinal inhibitions investigated in the cat none have been shown to involve amino acids, enkephalins or 5-hydroxytryptamine but there is evidence to suggest a role for noradrenaline.

Disulfide-bonding affinity labelling of neurokinin-1 (NK-1) receptors by Cys(Npys)-containing substance P analogs

1992 ◽  
Vol 37 ◽  
pp. S106
Author(s):  
H. Matsumoto ◽  
Y. Shimohigashi ◽  
K. Tateishi ◽  
R. Saito ◽  
Y. Takano ◽  
...  
Keyword(s):  
Substance P ◽  
Disulfide Bonding ◽  
Affinity Labelling ◽  
Neurokinin 1 ◽  
Substance P Analogs
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