Orexin-A is composed of a highly conservedC-terminal and a specific, hydrophilicN-terminal region, revealing the structural basis of specific recognition by the orexin-1 receptor

2006 ◽  
Vol 12 (7) ◽  
pp. 443-454 ◽  
Author(s):  
Tomoyo Takai ◽  
Takao Takaya ◽  
Mutsuko Nakano ◽  
Hideo Akutsu ◽  
Atsushi Nakagawa ◽  
...  
Keyword(s):  
Terminal Region ◽  
Structural Basis ◽  
Orexin A ◽  
Specific Recognition

scholarly journals Structural basis for the binding of the membrane-proximal C-terminal region of chemokine receptor CCR2 with the cytosolic regulator FROUNT

FEBS Journal ◽  
2014 ◽  
Vol 281 (24) ◽  
pp. 5552-5566 ◽  
Author(s):  
Kaori Esaki ◽  
Sosuke Yoshinaga ◽  
Tatsuichiro Tsuji ◽  
Etsuko Toda ◽  
Yuya Terashima ◽  
...  
Keyword(s):  
Chemokine Receptor ◽  
Terminal Region ◽  
Structural Basis ◽  
Chemokine Receptor Ccr2

scholarly journals Structural Basis for the Specific Recognition of RET by the Dok1 Phosphotyrosine Binding Domain

2003 ◽  
Vol 279 (6) ◽  
pp. 4962-4969 ◽  
Author(s):  
Ning Shi ◽  
Sheng Ye ◽  
Mark Bartlam ◽  
Maojun Yang ◽  
Jing Wu ◽  
...  
Keyword(s):  
Binding Domain ◽  
Structural Basis ◽  
Specific Recognition ◽  
Phosphotyrosine Binding Domain

scholarly journals Contrasting Use of CCR5 Structural Determinants by R5 and R5X4 Variants within a Human Immunodeficiency Virus Type 1 Primary Isolate Quasispecies

2003 ◽  
Vol 77 (22) ◽  
pp. 12057-12066 ◽  
Author(s):  
Yanjie Yi ◽  
Anjali Singh ◽  
Farida Shaheen ◽  
Andrew Louden ◽  
ChuHee Lee ◽  
...  
Keyword(s):  
Human Immunodeficiency Virus ◽  
Human Immunodeficiency Virus Type ◽  
Virus Type ◽  
Terminal Region ◽  
Primary Isolate ◽  
Structural Basis ◽  
Immunodeficiency Virus ◽  
Hiv 1

ABSTRACT Macrophagetropic R5 human immunodeficiency virus type 1 (HIV-1) isolates often evolve into dualtropic R5X4 variants during disease progression. The structural basis for CCR5 coreceptor function has been studied in a limited number of prototype strains and suggests that R5 and R5X4 Envs interact differently with CCR5. However, differences between unrelated viruses may reflect strain-specific factors and do not necessarily represent changes resulting from R5 to R5X4 evolution of a virus in vivo. Here we addressed CCR5 domains involved in fusion for a large set of closely related yet functionally distinct variants within a primary isolate swarm, employing R5 and R5X4 Envs derived from the HIV-1 89.6PI quasispecies. R5 variants of 89.6PI could fuse using either N-terminal or extracellular loop CCR5 sequences in the context of CCR5/CXCR2 chimeras, similar to the unrelated R5 strain JRFL, but R5X4 variants of 89.6PI were highly dependent on the CCR5 N terminus. Similarly, R5 89.6PI variants and isolate JRFL tolerated N-terminal CCR5 deletions, but fusion by most R5X4 variants was markedly impaired. R5 89.6PI Envs also tolerated multiple extracellular domain substitutions, while R5X4 variants did not. In contrast to CCR5 use, fusion by R5X4 variants of 89.6PI was largely independent of the CXCR4 N-terminal region. Thus, R5 and R5X4 species from a single swarm differ in how they interact with CCR5. These results suggest that R5 Envs possess a highly plastic capacity to interact with multiple CCR5 regions and support the concept that viral evolution in vivo results from the emergence of R5X4 variants with the capacity to use the CXCR4 extracellular loops but demonstrate less-flexible interactions with CCR5 that are strongly dependent on the N-terminal region.

scholarly journals Structural Basis for Specific Recognition of Reelin by Its Receptors

Structure ◽  
2010 ◽  
Vol 18 (3) ◽  
pp. 320-331 ◽  
Author(s):  
Norihisa Yasui ◽  
Terukazu Nogi ◽  
Junichi Takagi
Keyword(s):  
Structural Basis ◽  
Specific Recognition

scholarly journals Structural basis of phosphodiesterase 6 inhibition by the C-terminal region of the γ-subunit

2009 ◽  
Vol 28 (22) ◽  
pp. 3613-3622 ◽  
Author(s):  
Brandy Barren ◽  
Lokesh Gakhar ◽  
Hakim Muradov ◽  
Kimberly K Boyd ◽  
S Ramaswamy ◽  
...  
Keyword(s):  
Terminal Region ◽  
Structural Basis ◽  
Γ Subunit

Structural basis for 5′-nucleotide base-specific recognition of guide RNA by human AGO2

Nature ◽  
2010 ◽  
Vol 465 (7299) ◽  
pp. 818-822 ◽  
Author(s):  
Filipp Frank ◽  
Nahum Sonenberg ◽  
Bhushan Nagar
Keyword(s):  
Structural Basis ◽  
Guide Rna ◽  
Specific Recognition ◽  
Nucleotide Base

Structural basis for specific recognition of single-stranded RNA by Toll-like receptor 13

2015 ◽  
Vol 22 (10) ◽  
pp. 782-787 ◽  
Author(s):  
Wen Song ◽  
Jia Wang ◽  
Zhifu Han ◽  
Yifan Zhang ◽  
Heqiao Zhang ◽  
...  
Keyword(s):  
Structural Basis ◽  
Toll Like Receptor ◽  
Specific Recognition

scholarly journals Structural Basis for Sequence-Specific Recognition of DNA by TAL Effectors

Science ◽  
2012 ◽  
Vol 335 (6069) ◽  
pp. 720-723 ◽  
Author(s):  
D. Deng ◽  
C. Yan ◽  
X. Pan ◽  
M. Mahfouz ◽  
J. Wang ◽  
...  
Keyword(s):  
Structural Basis ◽  
Tal Effectors ◽  
Specific Recognition
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