An efficient gel-phase synthesis of peptides on a high capacity flexible crosslinked polystyrene support: comparison with Merrifield resin

2002 ◽  
Vol 8 (5) ◽  
pp. 183-191 ◽  
Author(s):  
I. M. Krishna Kumar ◽  
V. N. Rajasekharan Pillai ◽  
Beena Mathew
Keyword(s):  
High Capacity ◽  
Phase Synthesis ◽  
Crosslinked Polystyrene ◽  
Polystyrene Support ◽  
Merrifield Resin ◽  
Gel Phase

Festphasensynthese von Muramyldipeptiden an isomeren Trialkoxybenzylamin-Harzen / Solid Phase Synthesis of Muramyl Dipeptides on Isomeric Trialkoxybenzylamine Resins

1998 ◽  
Vol 53 (7) ◽  
pp. 753-764 ◽  
Author(s):  
Hans-Jürgen Kohlbaua ◽  
Jochen Tschakert ◽  
Raed A. Al-Qawasmeh ◽  
Tanveer Ahmad Nizamì ◽  
Abdul Malik ◽  
...  
Keyword(s):  
Amino Acids ◽  
Trifluoroacetic Acid ◽  
Solid Phase Synthesis ◽  
Solid Phase ◽  
Subsequent Treatment ◽  
Phase Synthesis ◽  
Merrifield Resin

Abstract New isomeric trialkoxybenzylamine resins are developed coupling phthalimidomethyl-3,5-dimethoxyphenols to the Merrifield resin, followed by subsequent treatment with hydrazine. The generated benzylamine function allows DCC coupling w ith the carboxyl function of amino acids and peptides which are removed as amides after treatment with trifluoroacetic acid. These new trialkoxybenzylamine resins allow expeditious syntheses of peptide amides and glycopeptide amides as is demonstrated for muramyl peptides and analogues.

Fluorinated linkers for monitoring solid-phase synthesis using gel-phase 19F NMR spectroscopy

1998 ◽  
Vol 39 (39) ◽  
pp. 7193-7196 ◽  
Author(s):  
Anette Svensson ◽  
Karl-Erik Bergquist ◽  
Tomas Fex ◽  
Jan Kihlberg
Keyword(s):  
Nmr Spectroscopy ◽  
Solid Phase Synthesis ◽  
Solid Phase ◽  
19F Nmr ◽  
Phase Synthesis ◽  
19F Nmr Spectroscopy ◽  
Gel Phase
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