Peptide hydrogels for affinity‐controlled release of therapeutic cargo: Current and potential strategies

2021 ◽  
Author(s):  
Monessha Nambiar ◽  
Joel P. Schneider
Keyword(s):  
Controlled Release ◽  
Peptide Hydrogels

NIR light-responsive short peptide/2D NbSe2 nanosheets composite hydrogel with controlled-release capacity

2019 ◽  
Vol 7 (19) ◽  
pp. 3134-3142 ◽  
Author(s):  
Can Wu ◽  
Jing Liu ◽  
Bin Liu ◽  
Suyun He ◽  
Guoru Dai ◽  
...  
Keyword(s):  
Controlled Release ◽  
Drug Release ◽  
Composite Hydrogel ◽  
Short Peptide ◽  
Nir Light ◽  
Release Capacity ◽  
Peptide Hydrogels

The design of light-responsive peptide hydrogels with controllable drug release characteristics is still a challenge.

Injectable peptide hydrogels for controlled-release of opioids

MedChemComm ◽  
2016 ◽  
Vol 7 (3) ◽  
pp. 542-549 ◽  
Author(s):  
Charlotte Martin ◽  
Edith Oyen ◽  
Jeroen Mangelschots ◽  
Mathieu Bibian ◽  
Tanila Ben Haddou ◽  
...  
Keyword(s):  
Controlled Release ◽  
Drug Carrier ◽  
Subcutaneous Administration ◽  
Carrier System ◽  
Drug Carrier System ◽  
Peptide Hydrogels

Peptide-based hydrogels as a drug carrier system for the subcutaneous administration of morphine.

Controlled release antibiotics for dry powder lung delivery

2009 ◽  
Vol 00 (00) ◽  
pp. 090805050810080-8 ◽  
Author(s):  
Handoko Adi ◽  
Paul Michael Young ◽  
Hak-Kim Chan ◽  
Rania Salama ◽  
Daniela Traini
Keyword(s):  
Controlled Release ◽  
Dry Powder ◽  
Lung Delivery

Controlled Release of Metformin Hydrochloride I. In vitro Release from Physical Mixture Containing Xanthan Gum as Hydrophilic Rate Retarding Polymer

1970 ◽  
Vol 4 (1) ◽  
Author(s):  
Mashkura Ashrafi ◽  
Jakir Ahmed Chowdhury ◽  
Md Selim Reza
Keyword(s):  
Controlled Release ◽  
Xanthan Gum ◽  
In Vitro Release ◽  
Correlation Coefficients ◽  
High Ratio ◽  
Water Soluble ◽  
Metformin Hydrochloride ◽  
Model Drug ◽  
Very High

Capsules of different formulations were prepared by using a hydrophilic polymer, xanthan gum and a filler Ludipress. Metformin hydrochloride, which is an anti-diabetic agent, was used as a model drug here with the aim to formulate sustained release capsules. In the first 6 formulations, metformin hydrochloride and xanthan gum were used in different ratio. Later, Ludipress was added to the formulations in a percentage of 8% to 41%. The total procedure was carried out by physical mixing of the ingredients and filling in capsule shells of size ‘1’. As metformin hydrochloride is a highly water soluble drug, the dissolution test was done in 250 ml distilled water in a thermal shaker (Memmert) with a shaking speed of 50 rpm at 370C &plusmn 0.50C for 6 hours. After the dissolution, the data were treated with different kinetic models. The results found from the graphs and data show that the formulations follow the Higuchian release pattern as they showed correlation coefficients greater than 0.99 and the sustaining effect of the formulations was very high when the xanthan gum was used in a very high ratio with the drug. It was also investigated that the Ludipress extended the sustaining effect of the formulation to some extent. But after a certain period, Ludipress did not show any significant effect as the pores made by the xanthan gum network were already blocked. It is found here that when the metformin hydrochloride and the xanthan gum ratio was 1:1, showed a high percentage of drug release, i.e. 91.80% of drug was released after 6 hours. But With a xanthan gum and metformin hydrochloride ratio of 6:1, a very slow release of the drug was obtained. Only 66.68% of the drug was released after 6 hours. The percent loading in this case was 14%. Again, when Ludipress was used in high ratio, it was found to retard the release rate more prominently. Key words: Metformin Hydrochloride, Xanthan Gum, Controlled release capsule Dhaka Univ. J. Pharm. Sci. Vol.4(1) 2005 The full text is of this article is available at the Dhaka Univ. J. Pharm. Sci. website

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