Chemical synthesis of the ubiquitinated form of histone H3 and its effect on DNA methyltransferase 1

2019 ◽  
Vol 25 (9) ◽  
Author(s):  
Toru Kawakami ◽  
Yuichi Mishima ◽  
Masaya Takazawa ◽  
Hironobu Hojo ◽  
Isao Suetake
Keyword(s):  
Chemical Synthesis ◽  
Dna Methyltransferase ◽  
Histone H3 ◽  
Dna Methyltransferase 1 ◽  
Methyltransferase 1

scholarly journals Human DNA Methyltransferase 1 Is Required for Maintenance of the Histone H3 Modification Pattern

2004 ◽  
Vol 279 (35) ◽  
pp. 37175-37184 ◽  
Author(s):  
Jesus Espada ◽  
Esteban Ballestar ◽  
Mario F. Fraga ◽  
Ana Villar-Garea ◽  
Angeles Juarranz ◽  
...  
Keyword(s):  
Dna Methyltransferase ◽  
Histone H3 ◽  
Dna Methyltransferase 1 ◽  
Human Dna ◽  
Methyltransferase 1

scholarly journals DNMT1 reads heterochromatic H4K20me3 to reinforce LINE-1 DNA methylation

2021 ◽  
Vol 12 (1) ◽  
Author(s):  
Wendan Ren ◽  
Huitao Fan ◽  
Sara A. Grimm ◽  
Jae Jin Kim ◽  
Linhui Li ◽  
...  
Keyword(s):  
Dna Methylation ◽  
Dna Methyltransferase ◽  
Histone H3 ◽  
Genomic Stability ◽  
Mammalian Genome ◽  
Dna Methyltransferase 1 ◽  
Chromatin Modifications ◽  
Direct Link ◽  
Histone H4 ◽  
Radiation Induced

AbstractDNA methylation and trimethylated histone H4 Lysine 20 (H4K20me3) constitute two important heterochromatin-enriched marks that frequently cooperate in silencing repetitive elements of the mammalian genome. However, it remains elusive how these two chromatin modifications crosstalk. Here, we report that DNA methyltransferase 1 (DNMT1) specifically ‘recognizes’ H4K20me3 via its first bromo-adjacent-homology domain (DNMT1BAH1). Engagement of DNMT1BAH1-H4K20me3 ensures heterochromatin targeting of DNMT1 and DNA methylation at LINE-1 retrotransposons, and cooperates with the previously reported readout of histone H3 tail modifications (i.e., H3K9me3 and H3 ubiquitylation) by the RFTS domain to allosterically regulate DNMT1’s activity. Interplay between RFTS and BAH1 domains of DNMT1 profoundly impacts DNA methylation at both global and focal levels and genomic resistance to radiation-induced damage. Together, our study establishes a direct link between H4K20me3 and DNA methylation, providing a mechanism in which multivalent recognition of repressive histone modifications by DNMT1 ensures appropriate DNA methylation patterning and genomic stability.

scholarly journals DNA methyltransferase 1, cytosine methylation, and cytosine hydroxymethylation in mammalian mitochondria

2011 ◽  
Vol 108 (9) ◽  
pp. 3630-3635 ◽  
Author(s):  
Lisa S. Shock ◽  
Prashant V. Thakkar ◽  
Erica J. Peterson ◽  
Richard G. Moran ◽  
Shirley M. Taylor
Keyword(s):  
Dna Methyltransferase ◽  
Cytosine Methylation ◽  
Dna Methyltransferase 1 ◽  
Mammalian Mitochondria ◽  
Methyltransferase 1

scholarly journals Role of DNA methyltransferase 1 on the altered eNOS expression in human umbilical endothelium from intrauterine growth restricted fetuses

Epigenetics ◽  
2013 ◽  
Vol 8 (9) ◽  
pp. 944-952 ◽  
Author(s):  
Bernardo J Krause ◽  
Paula M Costello ◽  
Ernesto Muñoz-Urrutia ◽  
Karen A Lillycrop ◽  
Mark A Hanson ◽  
...  
Keyword(s):  
Dna Methyltransferase ◽  
Dna Methyltransferase 1 ◽  
Enos Expression ◽  
Intrauterine Growth ◽  
Methyltransferase 1

scholarly journals DNA Methyltransferase 1 Is Indispensable for Development of the Hippocampal Dentate Gyrus

2016 ◽  
Vol 36 (22) ◽  
pp. 6050-6068 ◽  
Author(s):  
Hirofumi Noguchi ◽  
Naoya Murao ◽  
Ayaka Kimura ◽  
Taito Matsuda ◽  
Masakazu Namihira ◽  
...  
Keyword(s):  
Dentate Gyrus ◽  
Dna Methyltransferase ◽  
Dna Methyltransferase 1 ◽  
Hippocampal Dentate Gyrus ◽  
Methyltransferase 1
Sign in / Sign up

Export Citation Format

Share Document