An inhibitory mechanism of action of coiled‐coil peptides against type three secretion system from enteropathogenicEscherichia coli

2019 ◽  
Vol 25 (3) ◽  
Author(s):  
Mariano Larzábal ◽  
Hector A. Baldoni ◽  
Fernando D. Suvire ◽  
Lucrecia M. Curto ◽  
Gabriela E. Gomez ◽  
...  
Keyword(s):  
Mechanism Of Action ◽  
Coiled Coil ◽  
Secretion System ◽  
Inhibitory Mechanism ◽  
Type Three Secretion System ◽  
Type Three Secretion

scholarly journals Designed Coiled-Coil Peptides Inhibit the Type Three Secretion System of Enteropathogenic Escherichia coli

PLoS ONE ◽  
2010 ◽  
Vol 5 (2) ◽  
pp. e9046 ◽  
Author(s):  
Mariano Larzábal ◽  
Elsa C. Mercado ◽  
Daniel A. Vilte ◽  
Hector Salazar-González ◽  
Angel Cataldi ◽  
...  
Keyword(s):  
Escherichia Coli ◽  
Coiled Coil ◽  
Secretion System ◽  
Enteropathogenic Escherichia Coli ◽  
Type Three Secretion System ◽  
Type Three Secretion

scholarly journals Plasmid composition in Aeromonas salmonicida subsp. salmonicida 01-B526 unravels unsuspected type three secretion system loss patterns

BMC Genomics ◽  
2017 ◽  
Vol 18 (1) ◽  
Author(s):  
Katherine H. Tanaka ◽  
Antony T. Vincent ◽  
Jean-Guillaume Emond-Rheault ◽  
Marcin Adamczuk ◽  
Michel Frenette ◽  
...  
Keyword(s):  
Secretion System ◽  
Aeromonas Salmonicida ◽  
Type Three Secretion System ◽  
Type Three Secretion

scholarly journals Type Three Secretion System-Dependent Microvascular Thrombosis and Ischemic Enteritis in Human Gut Xenografts Infected with Enteropathogenic Escherichia coli

2017 ◽  
Vol 85 (11) ◽  
Author(s):  
Einat Nissim-Eliraz ◽  
Eilam Nir ◽  
Irit Shoval ◽  
Noga Marsiano ◽  
Israel Nissan ◽  
...  
Keyword(s):  
Escherichia Coli ◽  
Blood Vessels ◽  
Secretion System ◽  
Infection Model ◽  
Apical Surface ◽  
Muscularis Mucosa ◽  
Human Gut ◽  
Type Three Secretion System ◽  
Type Three Secretion ◽  
Ischemic Enteritis

ABSTRACT Enteropathogenic Escherichia coli (EPEC) is a leading cause of severe intestinal disease and infant mortality in developing countries. Virulence is mediated by a type three secretion system (T3SS), causing the hallmark attaching and effacing (AE) lesions and actin-rich pedestal formation beneath the infecting bacteria on the apical surface of enterocytes. EPEC is a human-specific pathogen whose pathogenesis cannot be studied in animal models. We therefore established an EPEC infection model in human gut xenografts in SCID mice and used it to study the role of T3SS in the pathogenesis of the disease. Following EPEC O127:H6 strain E2348/69 infection, T3SS-dependent AE lesions and pedestals were demonstrated in all infected xenografts. We report here the development of T3SS-dependent intestinal thrombotic microangiopathy (iTMA) and ischemic enteritis in ∼50% of infected human gut xenografts. Using species-specific CD31 immunostaining, we showed that iTMA was limited to the larger human-mouse chimeric blood vessels, which are located between the muscularis mucosa and circular muscular layer of the human gut. These blood vessels were massively invaded by bacteria, which adhered to and formed pedestals on endothelial cells and aggregated with mouse neutrophils in the lumen. We conclude that endothelial infection, iTMA, and ischemic enteritis might be central mechanisms underlying severe EPEC-mediated disease.

Aeromonas salmonicida Ati2 is an effector protein of the type three secretion system

Microbiology ◽  
2013 ◽  
Vol 159 (Pt_9) ◽  
pp. 1937-1945 ◽  
Author(s):  
Stéphanie Dallaire-Dufresne ◽  
Xavier Barbeau ◽  
Darren Sarty ◽  
Katherine H. Tanaka ◽  
Alix M. Denoncourt ◽  
...  
Keyword(s):  
Secretion System ◽  
Aeromonas Salmonicida ◽  
Effector Protein ◽  
Type Three Secretion System ◽  
Type Three Secretion
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