scholarly journals Further applications of classical amide coupling reagents: Microwave-assisted esterification on solid phase

2018 ◽  
Vol 24 (8-9) ◽  
pp. e3111 ◽  
Author(s):  
Risa Takayama ◽  
Shun Hayakawa ◽  
Hiroshi Hinou ◽  
Fernando Albericio ◽  
Fayna Garcia-Martin
Keyword(s):  
Solid Phase ◽  
Coupling Reagents ◽  
Microwave Assisted ◽  
Amide Coupling

scholarly journals Identification of VOCs in essential oils extracted using ultrasound- and microwave-assisted methods from sweet cherry flower

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Huimin Zhang ◽  
Hongguang Yan ◽  
Quan Li ◽  
Hui Lin ◽  
Xiaopeng Wen
Keyword(s):  
Essential Oil ◽  
Sweet Cherry ◽  
Dimethyl Sulfide ◽  
Solid Phase ◽  
Oil Yield ◽  
Gas Chromatography Mass Spectrometry ◽  
Process Conditions ◽  
Important Indicator ◽  
Microwave Assisted ◽  
Essential Oil Yield

AbstractThe floral fragrance of plants is an important indicator in their evaluation. The aroma of sweet cherry flowers is mainly derived from their essential oil. In this study, based on the results of a single-factor experiment, a Box–Behnken design was adopted for ultrasound- and microwave-assisted extraction of essential oil from sweet cherry flowers of the Brooks cultivar. With the objective of extracting the maximum essential oil yield (w/w), the optimal extraction process conditions were a liquid–solid ratio of 52 mL g−1, an extraction time of 27 min, and a microwave power of 435 W. The essential oil yield was 1.23%, which was close to the theoretical prediction. The volatile organic compounds (VOCs) of the sweet cherry flowers of four cultivars (Brooks, Black Pearl, Tieton and Summit) were identified via headspace solid phase microextraction (SPME) and gas chromatography–mass spectrometry (GC–MS). The results showed that a total of 155 VOCs were identified and classified in the essential oil from sweet cherry flowers of four cultivars, 65 of which were shared among the cultivars. The highest contents of VOCs were aldehydes, alcohols, ketones and esters. Ethanol, linalool, lilac alcohol, acetaldehyde, (E)-2-hexenal, benzaldehyde and dimethyl sulfide were the major volatiles, which were mainly responsible for the characteristic aroma of sweet cherry flowers. It was concluded that the VOCs of sweet cherry flowers were qualitatively similar; however, relative content differences were observed in the four cultivars. This study provides a theoretical basis for the metabolism and regulation of the VOCs of sweet cherry flowers.

Microwave-Assisted Solid-Phase Synthesis (MASS): Parallel and Combinatorial Chemical Library Synthesis

ChemInform ◽  
2004 ◽  
Vol 35 (7) ◽  
Author(s):  
Fahad Al-Obeidi ◽  
Richard E. Austin ◽  
John F. Okonya ◽  
Daniel R. S. Bond
Keyword(s):  
Solid Phase Synthesis ◽  
Solid Phase ◽  
Library Synthesis ◽  
Chemical Library ◽  
Phase Synthesis ◽  
Microwave Assisted

scholarly journals Racemization-free synthesis of Nα-2-thiophenoyl-phenylalanine-2-morpholinoanilide enantiomers and their antimycobacterial activity

Amino Acids ◽  
2021 ◽  
Author(s):  
Lea Mann ◽  
Markus Lang ◽  
Philipp Schulze ◽  
Jan Henrik Halz ◽  
René Csuk ◽  
...  
Keyword(s):  
Title Compound ◽  
Mammalian Cells ◽  
Antimycobacterial Activity ◽  
Lead Compound ◽  
Coupling Reagents ◽  
Hydrogen Bonding Interactions ◽  
Amide Coupling ◽  
Subsequent Separation ◽  
Synthetic Routes ◽  
Insight Into

AbstractNα-2-thiophenoyl-d-phenylalanine-2-morpholinoanilide (MMV688845, IUPAC: N-(1-((2-morpholinophenyl)amino)-1-oxo-3-phenylpropan-2-yl)thiophene-2-carboxamide) from the Pathogen Box® library (Medicines for Malaria Ventures, MMV) is a promising lead compound for antimycobacterial drug development. Two straightforward synthetic routes to the title compound starting from phenylalanine or its Boc-protected derivative are reported. Employing Boc-phenylalanine as starting material and the T3P® and PyBOP® amide coupling reagents enables racemization-free synthesis, avoiding the need for subsequent separation of the enantiomers. The crystal structure of the racemic counterpart gives insight into the molecular structure and hydrogen bonding interactions in the solid state. The R-enantiomer of the title compound (derived from d-phenylalanine) exhibits activity against non-pathogenic and pathogenic mycobacterial strains, whereas the S-enantiomer is inactive. Neither of the enantiomers and the racemate of the title compound shows cytotoxicity against various mammalian cells.

Microwave-assisted guanidinylation in solid phase peptide synthesis: comparison of various reagents

2014 ◽  
Vol 55 (45) ◽  
pp. 6198-6203 ◽  
Author(s):  
Ewa Witkowska ◽  
Karolina Kubik ◽  
Jolanta Krosnicka ◽  
Karolina Grabowska ◽  
Anna Niescioruk ◽  
...  
Keyword(s):  
Peptide Synthesis ◽  
Solid Phase ◽  
Solid Phase Peptide Synthesis ◽  
Microwave Assisted

Microwave-Assisted Solid-Phase Synthesis of a 1,2-Disubstituted Benzimidazole Library by Using a Phosphonium Linker

2013 ◽  
Vol 50 (3) ◽  
pp. 720-726 ◽  
Author(s):  
Natalia Ríos ◽  
Cecilia Chavarría ◽  
Carmen Gil ◽  
Williams Porcal
Keyword(s):  
Solid Phase Synthesis ◽  
Solid Phase ◽  
Phase Synthesis ◽  
Microwave Assisted
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