Synthesis, radiolabeling, and preclinical evaluation of a new octreotide analog for somatostatin receptor-positive tumor scintigraphy

2012 ◽  
Vol 18 (12) ◽  
pp. 720-730 ◽  
Author(s):  
Kakali De ◽  
Arijit Bhowmik ◽  
Ashok Behera ◽  
Indranil Banerjee ◽  
Mrinal Kanti Ghosh ◽  
...  
Keyword(s):  
Somatostatin Receptor ◽  
Preclinical Evaluation ◽  
Tumor Scintigraphy

scholarly journals Preclinical Evaluation of the α-Particle Generator Nuclide 225Ac for Somatostatin Receptor Radiotherapy of Neuroendocrine Tumors

2008 ◽  
Vol 14 (11) ◽  
pp. 3555-3561 ◽  
Author(s):  
Matthias Miederer ◽  
Gjermund Henriksen ◽  
Andrea Alke ◽  
Ilona Mossbrugger ◽  
Leticia Quintanilla-Martinez ◽  
...  
Keyword(s):  
Neuroendocrine Tumors ◽  
Somatostatin Receptor ◽  
Preclinical Evaluation ◽  
Particle Generator

scholarly journals “In-house” preparation of 99mTc-EDDA/HYNIC-TOC, a specific targeting agent for somatostatin receptor scintigraphy

2011 ◽  
Vol 57 ◽  
pp. 65-70
Author(s):  
Sonja Kuzmanovska ◽  
Olivija Vaskova ◽  
Marina Zdraveska Kocovska
Keyword(s):  
Somatostatin Receptor ◽  
Somatostatin Receptors ◽  
Somatostatin Receptor Scintigraphy ◽  
Safe Alternative ◽  
Energy Agency ◽  
Preclinical Evaluation ◽  
Specific Targeting ◽  
Evaluation Procedures ◽  
Freeze Dried ◽  
Receptor Scintigraphy

The use of radiolabeled peptide ligands as diagnostics and therapeutics in nuclear oncology has increased recently. One of the most frequently used radiopharmaceutical is 99mTc-EDDA/HYNIC-TOC, a somatostatin analog with affinity for certain types of somatostatin receptors, overexpressed in tumors of neuroendocrine origin. The radiopharmaceutical is not readily available; therefore we introduced its “in house” preparation within project activities supported by the International Atomic Energy Agency (IAEA). We optimized the radiolabeling protocol, prepared a small batch of frozen kits, performed ITLC quality control and animal biodistribution during the preclinical evaluation procedures. The co-ligand exchange labeling procedure was carried out at 100°C during 10 min, resulting in radiochemical purity >90%. The biodistribution scintigrams in normal Wistar rats showed rapid blood clearance after 15 min and predominant kidney accumulation after 4 h, in accordance with the data reported by other authors. Storage stability of the formulated small batch frozen kit (-20°C) was evaluated within 6 months, with radiolabeling yield ranging between 94,3% and 96,9%. We conclude that frozen kit can be a safe alternative to the freeze-dried for small batch in house production, and after the satisfactory preclinical evaluation, the “in house” prepared 99mTc-EDDA/ HYNIC-TOC can be introduced in clinical practice as specific targeting agent for somatostatin receptor scintigraphy.

Radiosynthesis and Preclinical Evaluation of18F-Fluoroglycosylated Octreotate for Somatostatin Receptor Imaging

2016 ◽  
Vol 27 (11) ◽  
pp. 2707-2714 ◽  
Author(s):  
Simone Maschauer ◽  
Marcus Heilmann ◽  
Carmen Wängler ◽  
Ralf Schirrmacher ◽  
Olaf Prante
Keyword(s):  
Somatostatin Receptor ◽  
Receptor Imaging ◽  
Preclinical Evaluation ◽  
Somatostatin Receptor Imaging

Preclinical evaluation of [99mTc/EDDA/tricine/HYNIC0, 1-Nal3, Thr8]-octreotide as a new analogue in the detection of somatostatin-receptor-positive tumors

2007 ◽  
Vol 34 (6) ◽  
pp. 651-657 ◽  
Author(s):  
Mostafa Gandomkar ◽  
Reza Najafi ◽  
Mohammad Shafiei ◽  
Mohammad Mazidi ◽  
Sayed Esmaeil Sadat Ebrahimi
Keyword(s):  
Somatostatin Receptor ◽  
Preclinical Evaluation

Immunolocalization of somatostatin receptor ss12A in the human gastro-entero-pancreatic tract

2001 ◽  
Vol 120 (5) ◽  
pp. A511-A511
Author(s):  
P ROCHAIX ◽  
E PUENTE ◽  
P CORDELIER ◽  
T SAATI ◽  
G DELSOL ◽  
...  
Keyword(s):  
Somatostatin Receptor

Somatostatin receptor 5

2006 ◽  
Author(s):  
Chamel Khoury ◽  
Michael Greenwood
Keyword(s):  
Somatostatin Receptor

Preclinical evaluation of red grapes seeds extract from Vitis vinifera, Burgund Mare, Recas, Romania as skin photochemoprotective agent

Planta Medica ◽  
2011 ◽  
Vol 77 (12) ◽  
Author(s):  
P Bolfa ◽  
F Sarac ◽  
A Filip ◽  
A Gal ◽  
M Taulescu ◽  
...  
Keyword(s):  
Vitis Vinifera ◽  
Red Grapes ◽  
Preclinical Evaluation

Preclinical evaluation of the PARP-inhibitor olaparib for the treatment of ovarian clear cell cancer

2011 ◽  
Vol 71 (08) ◽  
Author(s):  
KJ Dedes ◽  
P Wilkerson ◽  
D Wetterskog ◽  
MB Lambros ◽  
R Natrajan ◽  
...  
Keyword(s):  
Clear Cell ◽  
Parp Inhibitor ◽  
Cell Cancer ◽  
Preclinical Evaluation
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