Multiple mechanisms account for variation in base-line sensitivity to azole fungicides in field isolates ofMycosphaerella graminicola

2003 ◽  
Vol 59 (12) ◽  
pp. 1333-1343 ◽  
Author(s):  
Ioannis Stergiopoulos ◽  
Johannes GM van Nistelrooy ◽  
Gert HJ Kema ◽  
Maarten A De Waard
Keyword(s):  
Base Line ◽  
Field Isolates ◽  
Azole Fungicides

On the Fibrinolytic System in Aged Rats, and Its Reactivity to Endotoxin and Cytokines

1992 ◽  
Vol 67 (06) ◽  
pp. 697-701 ◽  
Author(s):  
J J Emeis ◽  
A Brouwer ◽  
R J Barelds ◽  
M A Horan ◽  
S K Durham ◽  
...  
Keyword(s):  
Plasminogen Activator ◽  
Fibrinolytic Activity ◽  
Fibrinolytic System ◽  
Tissue Type ◽  
High Dose ◽  
Base Line ◽  
Aged Rats ◽  
Tissue Type Plasminogen Activator ◽  
Young Rats ◽  
Type Plasminogen Activator

SummaryAged rats are more susceptible to endotoxin-induced effects, including microthrombosis and platelet aggregation, than are young rats. To investigate whether changes in the fibrinolytic system might be involved, we investigated the fibrinolytic activity in plasma euglobulin fractions and tissues (lung and heart) of young (6-months old) and aged (24-months old) rats under baseline conditions and after challenge with endotoxin. Aged rats had lower plasma levels of tissue-type plasminogen activator (t-PA) and of urokinase-type PA (u-PA) activity. PA inhibitor (PAI) activity was higher in the plasma of aged rats, as was t-PA activity in lung and heart.Rats were treated with either a low dose (1 μg/kg) or a high dose (10 mg/kg) of endotoxin. Both treatments induced a transient phase of increased blood fibrinolytic activity, as evidenced by higher levels of tissue-type plasminogen activator (t-PA) activity and decreased levels of PA inhibitor (PAI) activity. Over time, the fibrinolytic activity decreased, probably due to increased levels of PA inhibitor.Both the early increase in t-PA activity, and the subsequent increase in PAI activity, were more pronounced in the aged rats, as compared with the younger rats, after the high dose of endotoxin. The aged rats also responded to an injection of interleukin-1β or tumor necrosis factor-α with a larger increase of PAI activity than did the younger rats.Together the data suggest that, compared to young rats, aged rats have a decreased base-line plasma fibrinolytic activity, while their fibrinolytic system is more responsive to challenge by endotoxin and cytokines.

Aggregation of Cat Platelets in Vitro

1970 ◽  
Vol 23 (03) ◽  
pp. 601-620 ◽  
Author(s):  
Th. B Tschopp
Keyword(s):  
Adenosine Monophosphate ◽  
Blood Collection ◽  
Base Line ◽  
Reversible Aggregation ◽  
Low Concentrations ◽  
Irreversible Aggregation ◽  
High Concentrations ◽  
Two Phases ◽  
Improved Technique

SummaryAggregation of cat platelets in the citrated plasma is examined by means of Born’s absorptiometer. A marked tendency of the platelets of this species to spontaneous aggregation necessitated first of all the development of an improved technique of blood collection.A hypothesis according to which 5-HT is released from the platelets, explains the absence of oscillations on the base line of the absorptiometer, the absence of platelet swelling, when ADP is added, and the effect of stirring on the aggregation curves in cat PRP. The average volume of cat platelets amounts to 10.46 μ3 when directly fixed in the blood, when fixed from PRP to 12.17 μ3, when fixed from stirred PRP to 13.51 μ3.In low concentrations (0.3-2 μM) ADP produce reversible aggregation; in narrowly restricted, individually dissimilar mean concentrations irreversible aggregation in two phases and in high concentrations, irreversible aggregation in one phase. Like ADP serotonin produces 2 phase irreversible aggregation in concentrations of 3-10 μM, but unlike ADP, the aggregation velocity decreases again with high 5-HT concentrations (>100 μM). Adrenaline does not produce aggregation and it is likely that adenosine and adenosine monophosphate inhibit the aggregation by serotonin but not by ADP. Species differences in the aggregation of human, rabbit and cat platelets are discussed.

Association of Variables of Coagulation, Fibrinolysis and Acute-phase with Atherosclerosis in Coronary and Peripheral Arteries and those Arteries Supplying the Brain

1995 ◽  
Vol 73 (03) ◽  
pp. 374-379 ◽  
Author(s):  
Jürgen Heinrich ◽  
Helmut Schulte ◽  
Rainer Schönfeld ◽  
Ekkehart Köhler ◽  
Gerd Assmann
Keyword(s):  
Acute Phase ◽  
Coronary Atherosclerosis ◽  
Plasminogen Activator Inhibitor ◽  
Arterial Disease ◽  
Plasma Fibrinogen ◽  
Base Line ◽  
Peripheral Arteries ◽  
Brain Vessels ◽  
The Brain ◽  
D Dimer

SummaryWe investigated the vessel status of coronary and peripheral arteries and those arteries supplying the brain in 929 consecutive male patients admitted to a coronary rehabilitation unit. The severity of coronary atherosclerosis was scored using coronary angiography. Changes in extracranial brain vessels and manifest cerebrovascular disease (CVD) were determined by B-mode ultrasound and Doppler examination. Peripheral arterial disease (PAD) was diagnosed using base-line and stress oscillography. We assessed variables of coagulation, fibrinolysis, and the acute phase response.There was a significant increase in plasma fibrinogen, plasminogen, d-dimer and C-reactive protein (CRP) with increasing severity of coronary heart disease. Compared to men with unaffected arteries, men with 3 diseased coronary arteries had 58% greater d-dimer concentrations. Patients with CVD and PAD, respectively, also had significantly higher fibrinogen, d-dimer and CRP concentrations. We did not find an association between plasminogen activator inhibitor activity and the severity of coronary atherosclerosis.In conclusion, plasma fibrinogen, d-dimer and CRP concentrations were significantly related to atherosclerosis in the coronary, peripheral and extracranial brain arteries.

STATISTICAL METHODS FOR THE ASSESSMENT OF AIR POLLUTION OF JHANSI CITY, UTTAR PRADESH, INDIA

2018 ◽  
Vol 24 (1) ◽  
Author(s):  
V. S. CHAUHAN ◽  
BHANUMATI SINGH ◽  
SHREE GANESH ◽  
JAMSHED ZAIDI
Keyword(s):  
Air Pollution ◽  
Uttar Pradesh ◽  
Ambient Air ◽  
Ambient Air Pollution ◽  
Base Line ◽  
Multivariate Statistical ◽  
Large Cities ◽  
Governmental Organizations ◽  
Non Governmental Organizations ◽  
The Status

Studies on air pollution in large cities of India showed that ambient air pollution concentrations are at such levels where serious health effects are possible. This paper presents overview on the status of air quality index (AQI) of Jhansi city by using multivariate statistical techniques. This base line data can help governmental and non-governmental organizations for the management of air pollution.

Vitamin D levels in Lebanese population: do we need to alter the base line for insufficiency?

2014 ◽  
Author(s):  
Yasser Yaghi ◽  
Ziad El Zaatari ◽  
Hassan Kazma ◽  
Wajih Zaiour ◽  
Ahmad Abdallah
Keyword(s):  
Vitamin D ◽  
Base Line ◽  
Vitamin D Levels ◽  
Lebanese Population

An assessment of toxic metals content in the marine sediments of the Shuaiba Industrial Area, Kuwait, after the oil spill during the Gulf War

1996 ◽  
Vol 34 (7-8) ◽  
pp. 203-210 ◽  
Author(s):  
S. Al-Muzaini ◽  
P. G. Jacob
Keyword(s):  
Oil Spill ◽  
Marine Sediment ◽  
Oil Spills ◽  
Industrial Area ◽  
Gulf War ◽  
Oil Wells ◽  
Environmental Damage ◽  
Base Line ◽  
Sampling Locations ◽  
Very High

A field study was carried out involving seven fixed sampling stations. The sampling locations were selected to cover the distribution of pollutants in the Shuaiba Industrial Area (SIA), which was contaminated with oil released from oil wells and broken pipelines and with a vast amount of burnt and unburnt crude oil from the burning and gushing oil wells. The samples were collected biweekly between July 1993 and July 1994. The concentrations of V, Ni, Cr, Cd and Pb were determined and compared with the previously collected baseline data to assess the degree of environmental damage caused due to the oil spills during the Gulf war. The average concentrations (mg/kg) of various elements in the marine sediment were 17.3 for V, 30.8 for Ni, 55.5 for Cr, 0.02 for Cd and 1.95 for Pb. Our results show that even after the heavy spillage of oil, associated metal concentrations were not very high compared with previously reported base line values.

Sign in / Sign up

Export Citation Format

Share Document