Cytochrome P450 ‐mediated herbicide metabolism in plants: current understanding and prospects

2020 ◽  
Vol 77 (1) ◽  
pp. 22-32
Author(s):  
Niña Gracel Dimaano ◽  
Satoshi Iwakami
Keyword(s):  
Cytochrome P450 ◽  
Current Understanding ◽  
Herbicide Metabolism

Cytochrome P450 Endowed Herbicide Metabolism

1997 ◽  
pp. 101-108 ◽  
Author(s):  
F. Durst ◽  
J. P. Salaün ◽  
D. Werck-Reichhart ◽  
F. Zimmerlin
Keyword(s):  
Cytochrome P450 ◽  
Herbicide Metabolism

scholarly journals Engineering Herbicide Metabolism in Tobacco and Arabidopsis with CYP76B1, a Cytochrome P450 Enzyme from Jerusalem Artichoke

2002 ◽  
Vol 130 (1) ◽  
pp. 179-189 ◽  
Author(s):  
Luc Didierjean ◽  
Laurence Gondet ◽  
Roberta Perkins ◽  
Sze-Mei Cindy Lau ◽  
Hubert Schaller ◽  
...  
Keyword(s):  
Cytochrome P450 ◽  
Jerusalem Artichoke ◽  
Cytochrome P450 Enzyme ◽  
Herbicide Metabolism ◽  
P450 Enzyme

scholarly journals Resistance Mechanism to Metsulfuron-Methyl in Polypogon fugax

Plants ◽  
2021 ◽  
Vol 10 (7) ◽  
pp. 1309
Author(s):  
Xiaoyue Yu ◽  
Hanwen Wu ◽  
Jianping Zhang ◽  
Yongjie Yang ◽  
Wei Tang ◽  
...  
Keyword(s):  
Cytochrome P450 ◽  
Sequence Analysis ◽  
Synergistic Effect ◽  
Enzymatic Activity ◽  
Resistance Mechanism ◽  
Acetolactate Synthase ◽  
Metsulfuron Methyl ◽  
Herbicide Metabolism ◽  
Glutathione S Transferases ◽  
Gst Activity

Polypogon fugax is a common winter weed in China and other Asia countries. We have previously found a P. fugax biotype (R) resistant to acetyl co-enzyme A carboxylase (ACCase) herbicides also cannot be effectively controlled by some acetolactate synthase (ALS) herbicides. This study evaluated the level of resistance to four ALS herbicides (metsulfuron-methyl, chlorsulfuron, monosulfuron, pyribambenz isopropyl) in the R biotype and the associated resistance mechanism. The R biotype exhibited moderate level of resistance to metsulfuron-methyl (6.0-fold) compared with the sensitive biotype (S). Sequence analysis of ALS gene revealed that two ALS genes existed in P. fugax. However, no substitution associated with ALS resistance mechanism were found in ALS genes between the S and R biotypes. The activity of ALS enzyme isolated from the R biotype was inherently higher and less sensitive to metsulfuron-methyl than the S biotype. Glutathione S-transferases (GST) activity was also less sensitive to metsulfuron-methyl in the R than as the S biotypes. Malathion, a cytochrome P450 (CYP) monooxygenase inhibitor, had much greater synergistic effect with metsulfuron-methyl on the R than as the S plants, reducing the ED50 value (herbicide dose to inhibit growth by 50%) of metsulfuron-methyl by 23- and 6-fold, respectively, suggesting that CYP mediated enhanced metabolism might contribute to the resistance to ALS herbicides. These results suggest that metsulfuron-methyl resistance in the R biotype was associated with the up-regulated ALS enzymatic activity and the GST and CYP-mediated enhanced herbicide metabolism.

Purification and herbicide metabolism studies on tulip (Tulipa gesneriana) cytochrome P450

1993 ◽  
Vol 38 (1) ◽  
pp. 9-15 ◽  
Author(s):  
Ayşegül Topal ◽  
Nancy Adams ◽  
Walter C. Dauterman ◽  
Ernest Hodgson ◽  
Steven L. Kelly
Keyword(s):  
Cytochrome P450 ◽  
Tulipa Gesneriana ◽  
Herbicide Metabolism

Factors Affecting Differential Sensitivity of Sweet Corn to HPPD-Inhibiting Herbicides

Weed Science ◽  
2010 ◽  
Vol 58 (3) ◽  
pp. 289-294 ◽  
Author(s):  
Martin M. Williams ◽  
Jerald K. Pataky
Keyword(s):  
Cytochrome P450 ◽  
Mutant Allele ◽  
Genetic Basis ◽  
Sweet Corn ◽  
Differential Sensitivity ◽  
Corn Hybrids ◽  
Factors Affecting ◽  
Functional Allele ◽  
Herbicide Metabolism ◽  
Corn Hybrid

Mutation of a cytochrome P450 (CYP) allele on the short arm of chromosome 5 affects sensitivity in sweet corn to mesotrione and to tembotrione plus isoxadifen applied POST. Hybrids that are homozygous for the functional allele (i.e.,CYPCYP) are rarely injured at registered use rates, hybrids that are homozygous for mutant alleles (i.e.,cypcyp) are frequently injured, and hybrids that are heterozygous for a functional and mutant allele (i.e.,CYPcyp) have more variable responses over trials. The objectives of this work were (1) to conduct side-by-side comparisons of sweet corn hybrid responses to mesotrione, tembotrione plus isoxadifen, and topramezone under field conditions; and (2) to compare dose–response relationships amongCYPCYP,CYPcyp, andcypcyphybrids. Among 4-hydroxyphenylpyruvate dioxygenase (HPPD) inhibitors used POST in sweet corn, topramezone was safe on the 746 hybrids tested. When environmental conditions favored crop growth, mesotrione injured the largest number of hybrids, and these hybrids were almost exclusivelycypcyporCYPcyp. The safener isoxadifen added to the tembotrione product greatly reduced occurrence of injury to theCYPcypgenotypic class but not to thecypcyphybrids. Despite a common genetic basis for herbicide metabolism, genotypic classes of sweet corn hybrids did not have identical field responses to mesotrione, tembotrione plus isoxadifen, and topramezone.

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