From synthetic control to natural products: a focus on N -heterocycles

2019 ◽  
Vol 75 (9) ◽  
pp. 2385-2402 ◽  
Author(s):  
Cristina Prandi ◽  
Ernesto G Occhiato
Keyword(s):  
Natural Products ◽  
Synthetic Control

N,O-Heterocycles as synthetic intermediates

2008 ◽  
Vol 80 (4) ◽  
pp. 681-685 ◽  
Author(s):  
Roderick W. Bates ◽  
Jutatip Boonsombat ◽  
Yongna Lu ◽  
Joseph A. Nemeth ◽  
Kanicha Sa-Ei ◽  
...  
Keyword(s):  
Natural Products ◽  
Ring Opening ◽  
Cyclization Reaction ◽  
Synthetic Control ◽  
Synthetic Intermediates

Hydroxylamines can be cyclized under various conditions according to the nature of the unsaturation in the N-substituent. Both isoxazolidines and tetrahydrooxazines can be formed with good synthetic control. The choice of the appropriate cyclization reaction leads to syntheses of the natural products sedamine and monomorine. The related N,O-acetals are shown to undergo efficient ring-opening under Sakurai conditions.

Synthetic control leading to natural products

1982 ◽  
Vol 54 (12) ◽  
pp. 2455-2464 ◽  
Author(s):  
T. Mukaiyama
Keyword(s):  
Natural Products ◽  
Synthetic Control
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