Intermediate derivatisation method in the discovery of new acaricide candidates: synthesis ofN-substituted piperazine derivatives and their activity against phytophagous mites

2016 ◽  
Vol 73 (5) ◽  
pp. 945-952 ◽  
Author(s):  
Yong Xie ◽  
Ying Xu ◽  
Changling Liu ◽  
Aiying Guan ◽  
Lanfeng Ban ◽  
...  
Keyword(s):  
Phytophagous Mites ◽  
Piperazine Derivatives ◽  
Substituted Piperazine

scholarly journals Synthesis and Antimicrobial Activity of Some New Piperazine Derivaties Containing Aryl Sulfonyloxy Group

2004 ◽  
Vol 1 (2) ◽  
pp. 93-98 ◽  
Author(s):  
H. S. Patel ◽  
H. D. Desai ◽  
H. J. Mistry
Keyword(s):  
Antimicrobial Activity ◽  
Acetyl Chloride ◽  
Condensation Reaction ◽  
Piperazine Derivatives ◽  
Substituted Piperazine

NovelN-substituted piperazine derivatives containing sulfonyloxy aniline moiety have been prepared. The various 4-sulfonyloxy aniline (SA) derivatives (2a-h) have been prepared by the condensation reaction ofN-Acetyl Sulfanilyl chloride (ASC) and sodium phenates followed by hydrolysis. The SA derivatives are then reacted with chloro acetyl chloride to give corresponding (N-Chloroacetyl) derivatives (3a-h). These derivatives are then reacted withN-phenyl piperazine to yield the corresponding piperazine derivatives (4a-h).

Novel Tri-substituted Thiazoles Bearing Piperazine Ring: Synthesis and Evaluation of their Anticancer Activity

2019 ◽  
Vol 16 (5) ◽  
pp. 547-555 ◽  
Author(s):  
Asaf Evrim Evren ◽  
Leyla Yurttaş ◽  
Busra Eksellı ◽  
Gulsen Akalın-Cıftcı
Keyword(s):  
Anticancer Activity ◽  
Glioma Cells ◽  
Rat Glioma ◽  
Piperazine Derivatives ◽  
Lung Carcinoma Cells ◽  
Mtt Method ◽  
Human Lung Carcinoma ◽  
Abnormal Cells ◽  
Substituted Piperazine

Background: Cancer cells are described as an unregulated growth and spread of abnormal cells. Recently, cancer has become the most important major reason for deaths in the world. Methods: For anticancer activity, we have used the MTT method and determine the early/late apoptosis by flow cytometry. Results: The title compounds were procured by reacting 2-chloro-N-[4-(pyridin-4-yl)thiazol-2- yl]acetamide with some substituted piperazine derivatives. The in vitro anticancer activity of synthesized compounds was tested against C6 rat glioma cells and A549 human lung carcinoma cells. As a result, the compounds 3d, 3e, 3f and 3g have shown anticancer activity against both cell line. Conclusion: Specifically, compound 3f was determined as the most active compound against C6 rat glioma cells. Also, as understood, the core structure which is substituted with piperazine bridge, the heterocyclic aromatic derivatives are more active than phenyl or benzyl derivatives.

A new method for the preparation of unsymmetrical 1,4-substituted piperazine derivatives

1999 ◽  
Vol 10 (4) ◽  
pp. 799-811 ◽  
Author(s):  
Aurelio Ortiz ◽  
Norberto Farfán ◽  
Herbert Höpfl ◽  
Rosa Santillan ◽  
Marı́a E. Ochoa ◽  
...  
Keyword(s):  
New Method ◽  
Piperazine Derivatives ◽  
Substituted Piperazine

ChemInform Abstract: Synthesis, α-Adrenoceptors Affinity and α1-Adrenoceptor Antagonistic Properties of Some 1,4-Substituted Piperazine Derivatives.

ChemInform ◽  
2012 ◽  
Vol 43 (10) ◽  
pp. no-no
Author(s):  
H. Marona ◽  
M. Kubacka ◽  
B. Filipek ◽  
A. Siwek ◽  
M. Dybaia ◽  
...  
Keyword(s):  
Piperazine Derivatives ◽  
Substituted Piperazine

Synthesis and binding properties of new long-chain 4-substituted piperazine derivatives as 5-HT1A and 5-HT7 receptor ligands

2015 ◽  
Vol 25 (7) ◽  
pp. 1427-1430 ◽  
Author(s):  
Maria N. Modica ◽  
Sebastiano Intagliata ◽  
Valeria Pittalà ◽  
Loredana Salerno ◽  
Maria A. Siracusa ◽  
...  
Keyword(s):  
Receptor Ligands ◽  
Binding Properties ◽  
Piperazine Derivatives ◽  
Substituted Piperazine ◽  
Long Chain

scholarly journals Regioselective synthesis and preliminary cytotoxic activity properties of tetrazole appendage N-substituted piperazine derivatives

2017 ◽  
Vol 10 (3) ◽  
pp. 178-189
Author(s):  
Kommula Dileep ◽  
Mohana Rao Katiki ◽  
Busam Ramalingeswara Rao ◽  
V. P. S. Vishnu Vardhan ◽  
Ramakrishna Sistla ◽  
...  
Keyword(s):  
Cytotoxic Activity ◽  
Regioselective Synthesis ◽  
Piperazine Derivatives ◽  
Substituted Piperazine

Histamine Antagonists. III. 1- and 1,4-Substituted Piperazine Derivatives

1949 ◽  
Vol 71 (8) ◽  
pp. 2734-2736 ◽  
Author(s):  
K. E. Hamlin ◽  
Arthur W. Weston ◽  
Francis E. Fischer ◽  
R. J. Michaels
Keyword(s):  
Histamine Antagonists ◽  
Piperazine Derivatives ◽  
Substituted Piperazine
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