Cross resistance to juvenile hormone analogues in insecticide-resistant strains ofMusca domesticaL

1974 ◽  
Vol 5 (6) ◽  
pp. 759-767 ◽  
Author(s):  
David C. Cerf ◽  
George P. Georghiou
Keyword(s):  
Juvenile Hormone ◽  
Cross Resistance ◽  
Juvenile Hormone Analogues ◽  
Resistant Strains

Larva lights: A decade of photoaffinity labeling with juvenile hormone analogues

1994 ◽  
Vol 24 (8) ◽  
pp. 747-761 ◽  
Author(s):  
Glenn D. Prestwich ◽  
Kazushige Touhara ◽  
Lynn M. Riddiford ◽  
Bruce D. Hammock
Keyword(s):  
Juvenile Hormone ◽  
Photoaffinity Labeling ◽  
Juvenile Hormone Analogues

scholarly journals Development and silk production by silkworm larvae after topical application of methoprene

2002 ◽  
Vol 59 (3) ◽  
pp. 585-588 ◽  
Author(s):  
José Ednilson Miranda ◽  
Sérgio Antonio de Bortoli ◽  
Roque Takahashi
Keyword(s):  
Juvenile Hormone ◽  
Larval Instar ◽  
Negative Effects ◽  
Hormone Analogue ◽  
Insect Growth Regulators ◽  
Silkworm Larvae ◽  
Silk Production ◽  
Juvenile Hormone Analogues ◽  
Chemical Products ◽  
Silkworm Bombyx Mori

Juvenile hormone analogues have been tested as insect growth regulators in silkworm (Bombyx mori), seeking an increment of silk production. These chemical products, when applied in small or moderate rates, promote the extension of the last larval instar. To understand the physiologic consequences on silk production by the silkworm strain C115 x N108, the application of methoprene, a juvenile hormone analogue, was performed to evaluate its effects on larval development and silk production. Methoprene was topically applied 48h after the fourth larval ecdysis, on the dorsal integument of the 2nd thoracic segment of the insects, at seven rates between 0 and 20 ng a.i. Methoprene influenced positively the duration of the fifth instar and the weight gain of the insects. The application of 1ng methoprene resulted in the heaviest silkglands, cocoons, shell cocoons and pupae weights. Comparatively to the control, the increment on silk production (approximately 24%) by the use of 1ng methoprene was more accentuated than the corresponding negative effects on the cocooning rate (approximately 12%).

Effects of juvenile hormone mimics on the codling moth Cydia Pomonella (L.) (Lep., Olethreutidae)

1973 ◽  
Vol 63 (1) ◽  
pp. 7-16 ◽  
Author(s):  
I. Gelbič ◽  
F. Sehnal
Keyword(s):  
Juvenile Hormone ◽  
Laboratory Experiments ◽  
Cydia Pomonella ◽  
Codling Moth ◽  
The Other ◽  
Wide Range ◽  
Juvenile Hormone Analogues ◽  
Juvenile Hormone Mimics

AbstractLaboratory experiments with juvenile hormone analogues on Cydia pomonella (L.) showed that Cecropia C17 juvenile hormone (methyl 10,ll-epoxy-3,7,ll-trimethyl-2,6-dodecadienoate) was the most active of the 28 compounds tested. When applied to four-hour-old eggs at 0.1 μg/egg, the hormone caused 100% failure in embryogenesis, while the other compounds were at least five times less effective. Depending on the time since ecdysis and the dose, juvenile hormone mimics applied to last-instar larvae resulted in a wide range of intermediate forms. Against three-day-old last-instar larvae, the Cecropia C17 hormone gave 100% inhibition of development at a dose of 1 μg/larva, while three other compounds (methyl 10,11-epoxy-3,7,11-trimethyl-2,6-dodecadienoate, ethyl 11-chloro-3,7,11-trimethyl-2-dodecenoate and ethyl 3,7,11-tri-methyl-2,4-dodecadienoate) gave the same effect at 2–5 μg/larva. Against newly emerged adults, the last two compounds at 10–50 μg/insect reduced fecundity and fertility to 0–81% and 0–50%, respectively, of their normal levels.

Effects of 5 Juvenile Hormone Analogues Applied Topically to Cattle Naturally Infested with Hypoderma Larvae (Diptera: Oestridae)1

1975 ◽  
Vol 12 (5) ◽  
pp. 517-524
Author(s):  
R. L. Younger ◽  
J. E. Wright ◽  
H. E. Smalley ◽  
H. R. Crookshank ◽  
J. O. Norman
Keyword(s):  
Juvenile Hormone ◽  
Juvenile Hormone Analogues

scholarly journals Lead Optimization of Dehydroemetine for Repositioned Use in Malaria

2020 ◽  
Vol 64 (4) ◽  
Author(s):  
Priyanka Panwar ◽  
Kepa K. Burusco ◽  
Muna Abubaker ◽  
Holly Matthews ◽  
Andrey Gutnov ◽  
...  
Keyword(s):  
De Novo ◽  
Antimalarial Activity ◽  
Drug Repositioning ◽  
Multidrug Resistant ◽  
Cross Resistance ◽  
Synthetic Analogue ◽  
80S Ribosome ◽  
Content Type ◽  
Resistant Strains

ABSTRACT Drug repositioning offers an effective alternative to de novo drug design to tackle the urgent need for novel antimalarial treatments. The antiamoebic compound emetine dihydrochloride has been identified as a potent in vitro inhibitor of the multidrug-resistant strain K1 of Plasmodium falciparum (50% inhibitory concentration [IC50], 47 nM ± 2.1 nM [mean ± standard deviation]). Dehydroemetine, a synthetic analogue of emetine dihydrochloride, has been reported to have less-cardiotoxic effects than emetine. The structures of two diastereomers of dehydroemetine were modeled on the published emetine binding site on the cryo-electron microscopy (cryo-EM) structure with PDB code 3J7A (P. falciparum 80S ribosome in complex with emetine), and it was found that (−)-R,S-dehydroemetine mimicked the bound pose of emetine more closely than did (−)-S,S-dehydroisoemetine. (−)-R,S-dehydroemetine (IC50 71.03 ± 6.1 nM) was also found to be highly potent against the multidrug-resistant K1 strain of P. falciparum compared with (−)-S,S-dehydroisoemetine (IC50, 2.07 ± 0.26 μM), which loses its potency due to the change of configuration at C-1′. In addition to its effect on the asexual erythrocytic stages of P. falciparum, the compound exhibited gametocidal properties with no cross-resistance against any of the multidrug-resistant strains tested. Drug interaction studies showed (−)-R,S-dehydroemetine to have synergistic antimalarial activity with atovaquone and proguanil. Emetine dihydrochloride and (−)-R,S-dehydroemetine failed to show any inhibition of the hERG potassium channel and displayed activity affecting the mitochondrial membrane potential, indicating a possible multimodal mechanism of action.

PRELIMINARY STUDIES OF EFFECTS OF JUVENILE HORMONE ANALOGUES ON ADULT EMERGENCE OF BLACK FLIES (DIPTERA: SIMULIIDAE)

1973 ◽  
Vol 105 (3) ◽  
pp. 509-511 ◽  
Author(s):  
J. E. Cumming ◽  
B. McKague
Keyword(s):  
Juvenile Hormone ◽  
Adult Emergence ◽  
Complete Inhibition ◽  
Black Flies ◽  
Breeding Sites ◽  
Juvenile Hormone Analogues ◽  
Simulium Decorum

AbstractBreeding sites for Simulium venustum, Simulium arcticum, Simulium pugetense, Simulium hunteri, Simulium canadense, and Simulium decorum were found in the Vancouver area. Addition of juvenile hormone analogues to the rearing water of S. decorum resulted in virtually complete inhibition of adult emergence.

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