scholarly journals Effect of a common missense variant in LIPA gene on fatty liver disease and lipid phenotype: New perspectives from a single‐center observational study

2021 ◽  
Vol 9 (5) ◽  
Author(s):  
Andrea Pasta ◽  
Paolo Borro ◽  
Anna Laura Cremonini ◽  
Elena Formisano ◽  
Giulia Tozzi ◽  
...  
Keyword(s):  
Liver Disease ◽  
Observational Study ◽  
Fatty Liver ◽  
Fatty Liver Disease ◽  
Missense Variant ◽  
Single Center ◽  
Lipid Phenotype ◽  
Single Center Observational Study

scholarly journals Cognitive-Behavioral Treatment of Nonalcoholic Fatty Liver Disease: A Propensity Score-Adjusted Observational Study

Obesity ◽  
2011 ◽  
Vol 19 (4) ◽  
pp. 763-770 ◽  
Author(s):  
Simona Moscatiello ◽  
Raffaella Di Luzio ◽  
Elisabetta Bugianesi ◽  
Alessandro Suppini ◽  
Ingrid J. Hickman ◽  
...  
Keyword(s):  
Liver Disease ◽  
Propensity Score ◽  
Observational Study ◽  
Fatty Liver ◽  
Nonalcoholic Fatty Liver Disease ◽  
Fatty Liver Disease ◽  
Behavioral Treatment ◽  
Cognitive Behavioral ◽  
Cognitive Behavioral Treatment ◽  
Nonalcoholic Fatty Liver

scholarly journals Prevalence trends in non-alcoholic fatty liver disease at the global, regional and national levels, 1990–2017: a population-based observational study

BMJ Open ◽  
2020 ◽  
Vol 10 (8) ◽  
pp. e036663
Author(s):  
Xiaojun Ge ◽  
Limei Zheng ◽  
Mei Wang ◽  
Yuxuan Du ◽  
Junyao Jiang
Keyword(s):  
Liver Disease ◽  
Middle East ◽  
Observational Study ◽  
Fatty Liver ◽  
North Africa ◽  
Fatty Liver Disease ◽  
Population Based ◽  
Prevention Strategies ◽  
Alcoholic Fatty Liver ◽  
Alcoholic Fatty Liver Disease

ObjectiveNon-alcoholic fatty liver disease (NAFLD) is the leading cause of end-stage liver diseases worldwide. Understanding NAFLD prevalence and trends over time at the global, regional and national levels is critical to understanding the NAFLD disease burden and creating more tailored prevention strategies.DesignPopulation-based observational study.SettingThe study was global, including 21 regions and 195 countries or territories.Main outcomes measureThe estimated annual percentage change for NAFLD prevalence.ResultsWorldwide, cases of NAFLD have increased from 391.2 million in 1990 to 882.1 million in 2017, with the prevalence rate increasing from 8.2% to 10.9% during the same period. The increasing trends were consistent across sexes. Case numbers were highest in East Asia, followed by South Asia, then North Africa and the Middle East. The highest prevalence of NAFLD was observed in North Africa and the Middle East, while the greatest increase was detected in Western Europe, followed by Tropical Latin America, then high-income North America.ConclusionNearly all countries or territories worldwide have experienced a significant increase in NAFLD prevalence. The greatest increase was observed in Oman. Almost all countries showed a significant increasing trend in NAFLD prevalence over the past three decades. This drastic increase is alarming and suggests that NAFLD has emerged as a new public health concern worldwide. As such, more efficient prevention strategies are urgently needed.

scholarly journals Prevalence of nonalcoholic fatty liver disease in mental disorder inpatients in China: an observational study

2021 ◽  
Vol 15 (1) ◽  
pp. 127-136
Author(s):  
Qiuyue Ma ◽  
Fude Yang ◽  
Botao Ma ◽  
Wenzhan Jing ◽  
Jue Liu ◽  
...  
Keyword(s):  
Risk Factors ◽  
Bipolar Disorder ◽  
Liver Disease ◽  
Mental Disorders ◽  
Observational Study ◽  
Depressive Disorder ◽  
Mental Disorder ◽  
Fatty Liver ◽  
Fatty Liver Disease ◽  
Alcoholic Fatty Liver

Abstract Background and Purpose Non-alcoholic fatty liver disease (NAFLD) is becoming the most common liver disease in China. However, the understanding of NAFLD prevalence among Chinese mental disorder inpatients remains insufficient. We aim to investigate the prevalence of NAFLD among mental disorder inpatients in Beijing, China. Methods In this observational study, we included 66,273 mental disorder inpatients between 2014 and 2018, including inpatients with schizophrenia, bipolar disorder, depressive disorder and other mental disorders. Data were obtained from electronic health records of 19 specialized psychiatric hospitals in Beijing. NAFLD was defined by ICD-10 code, excluding other causes of liver disease. We calculated the overall and annual prevalence rates of NAFLD from 2014 to 2018, and compared NAFLD prevalence between sexes, age groups, mental disorders types, antipsychotics use, and comorbidities. Multivariable logistic regression was used to examine risk factors associated with NAFLD. Subgroup analysis was performed in different mental disorder types. Results The prevalence of NAFLD was 17.63% (95% CI 17.34–17.92%) in mental disorder inpatients, increasing from 16.88% in 2014 to 19.07% in 2018. The NAFLD prevalence in participants with schizophrenia (22.44%) was higher than that in participants with bipolar disorder (17.89%), depressive disorder (12.62%), and other mental disorders (12.99%). Women had similar or even higher NAFLD prevalence than men after 50 years. Men, 50–59 years (aOR = 1.71), schizophrenia (aOR = 1.56), bipolar disorder (aOR = 1.47), antipsychotics use (aOR = 1.46), hypertension (aOR = 1.50), diabetes (aOR = 1.83), dyslipidemia (aOR = 2.50) were risk factors for NAFLD in mental disorder inpatients. Conclusion NAFLD was common among Chinese mental disorder inpatients, and increased over years. The prevalence of NAFLD was higher among men, old women, inpatients with schizophrenia, bipolar disorder, antipsychotics, hypertension, diabetes, and dyslipidemia. Fatty liver disease among mental disorder population warrants the attention of psychiatric specialists and health policy-makers.

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