scholarly journals Ocular safety of repeated intravitreal injections of Carboplatin and Digoxin: A preclinical study on the healthy rabbits

2021 ◽  
Vol 9 (4) ◽  
Author(s):  
Alireza Khodabande ◽  
Fariba Ghassemi ◽  
Fahimeh Asadi Amoli ◽  
Hamid Riazi‐Esfahani ◽  
Raziyeh Mahmoudzadeh ◽  
...  
Keyword(s):  
Preclinical Study ◽  
Intravitreal Injections ◽  
Ocular Safety

scholarly journals Vitreous Inflammation Associated with Intravitreal Anti-VEGF Pharmacotherapy

2013 ◽  
Vol 2013 ◽  
pp. 1-6 ◽  
Author(s):  
Shivi Agrawal ◽  
Malav Joshi ◽  
John B. Christoforidis
Keyword(s):  
Vascular Endothelial Growth Factor ◽  
Growth Factor ◽  
Safety Profile ◽  
Intravitreal Injections ◽  
Retinal Diseases ◽  
Vascular Endothelial ◽  
Vital Importance ◽  
Anti Vegf ◽  
Endothelial Growth Factor ◽  
Ocular Safety

Vascular endothelial growth factor (VEGF) is a potent promoter of angiogenesis involved in a wide variety of physiologic processes. Intravitreal injections targeting VEGF have transformed the treatment of neovascular retinal diseases. Currently, there are four anti-VEGF agents in use: bevacizumab, ranibizumab, pegaptanib, and aflibercept. The success and frequency of anti-VEGF therapy have made the ocular safety profile of these agents of vital importance. This paper focuses on sterile endophthalmitis. In this paper, we compare the incidences of posttreatment sterile endophthalmitis among the four agents, review the mechanism of actions, and discuss the most prevalent hypotheses leading to sterile endophthalmitis.

PRECLINICAL STUDY OF THE VETERINARY DRUGS TOXICITY

1970 ◽  
pp. 61-64
Author(s):  
E. K. Rakhmatullin ◽  
O. D. Sklyarov
Keyword(s):  
Lethal Dose ◽  
Clinical Manifestations ◽  
Preclinical Study ◽  
Veterinary Drugs ◽  
Toxic Effects ◽  
Laboratory Animals ◽  
Therapeutic Effects ◽  
Significant Information ◽  
Important Indicator ◽  
Organ Systems

Preclinical study of the drugs toxicity was analysed it allows predicting the safety of veterinary drugs in laboratory animals. The fundamental normative instruments in the field of preclinical study of drugs for veterinary medicine and animal husbandry are Order of the Ministry of Agriculture of the Russian Federation dated 06.03.2018 N 101 and GOST 33044-2014 Principles of Good Laboratory Practice. An important indicator of the preclinical study of the veterinary drugs is the determination (calculation) of median lethal dose value (lethal dose for half of the animals tested) or concentration (LD50 or LC50). Existing methods for determining this indicator make it possible at the initial study stage to determine the degree and class the drug of toxicity. Studying the symptoms of intoxication in the analysis of pharmacological substances one obtains significant information about the nature of the action of the future drug. The clinical manifestations of intoxication with damage to various organ systems are presented. As criteria for assessing the toxic effects of veterinary drugs it is recommended to determine LD50, cumulation coefficient, latitude index of therapeutic effects, dose level of toxic effects in the experiment which allows predicting the nature and degree of toxic effects of the drug even at the stage of preclinical veterinary drugs study.

PRECLINICAL STUDY OF GENERAL TOXIC PROPERTIES OF THE TOOL Z-88 ON WHITE RATS

2020 ◽  
Vol 242 (2) ◽  
pp. 112-115
Author(s):  
F.A. Medetkhanov ◽  
◽  
V.G. Sofronov ◽  
E.K. Papunidi ◽  
M.I. Gilemkhanov ◽  
...  
Keyword(s):  
Preclinical Study ◽  
White Rats
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