scholarly journals Effects of omecamtiv mecarbil on failing human ventricular trabeculae and interaction with (−)‐noradrenaline

2021 ◽  
Vol 9 (3) ◽  
Author(s):  
Alexander Dashwood ◽  
Elizabeth Cheesman ◽  
Yee Weng Wong ◽  
Haris Haqqani ◽  
Nicole Beard ◽  
...  
Keyword(s):  
Omecamtiv Mecarbil ◽  
Ventricular Trabeculae

Effect of Varying Degrees of Hepatic Impairment on the Pharmacokinetics of Omecamtiv Mecarbil

2021 ◽  
Author(s):  
Ashit Trivedi ◽  
Rajneet K. Oberoi ◽  
Mia Mackowski ◽  
Pegah Jafarinasabian ◽  
Hanze Zhang ◽  
...  
Keyword(s):  
Hepatic Impairment ◽  
Omecamtiv Mecarbil

Effect of Omecamtiv Mecarbil on the Pharmacokinetics of Metformin, a Probe Substrate for MATE1/MATE2-K, in Healthy Subjects

2021 ◽  
Author(s):  
Ashit Trivedi ◽  
Rajneet K. Oberoi ◽  
Pegah Jafarinasabian ◽  
Hanze Zhang ◽  
Marintan Spring ◽  
...  
Keyword(s):  
Healthy Subjects ◽  
Omecamtiv Mecarbil

Contractile effects of cardiac neuropeptides in isolated canine atrial and ventricular muscles

1989 ◽  
Vol 257 (4) ◽  
pp. H1082-H1087 ◽  
Author(s):  
D. F. Rigel ◽  
I. L. Grupp ◽  
A. Balasubramaniam ◽  
G. Grupp
Keyword(s):  
Isometric Force ◽  
Contractile Force ◽  
Adrenergic Blockade ◽  
Canine Heart ◽  
Inotropic Action ◽  
Inotropic Effects ◽  
Calcitonin Gene ◽  
Positive Inotropic Effects ◽  
The Right ◽  
Ventricular Trabeculae

Contractile effects of the cardiac neuropeptides vasoactive intestinal polypeptide (VIP), peptide histidine isoleucine (PHI), neuropeptide Y (NPY), calcitonin gene-related peptide (CGRP), and neurotensin (NT) were compared with those of l-isoproterenol (ISO) in isolated canine atrial and ventricular trabeculae muscles stimulated to contract at 1 Hz. In ventricular muscles, ISO, VIP, and PHI augmented developed isometric force by approximately 100%. VIP and PHI were three times and 1/10, respectively, as potent as ISO. VIP also exhibited positive inotropic effects in atrial trabeculae. The contractile responses to VIP were unchanged after beta-adrenergic blockade with nadolol at a concentration (10 microM) that shifted the ISO dose-response curve two to three orders of magnitude to the right. In atrial and ventricular trabeculae, NPY (1 microM) attenuated contractile force by 36 +/- 8 and 30 +/- 4%, respectively. Each peptide also caused comparable increases or decreases in the rate of development of force and the rate of relaxation. CGRP and NT caused no significant changes in developed force in either atrial or ventricular muscles in concentrations up to 1 microM. Our results indicate a potential positive inotropic action of endogenous VIP and PHI and a cardiodepressant effect of endogenous NPY in the canine heart.

Pharmacokinetics, disposition, and biotransformation of [14C]-omecamtiv mecarbil in healthy male subjects after a single intravenous or oral dose.

2021 ◽  
pp. DMD-AR-2021-000444
Author(s):  
Ashit Trivedi ◽  
Jan Wahlstrom ◽  
Mia Mackowski ◽  
Sandeep Dutta ◽  
Edward Lee
Keyword(s):  
Oral Dose ◽  
Healthy Male ◽  
Omecamtiv Mecarbil ◽  
Male Subjects
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