scholarly journals NR1I2 genetic polymorphisms and the risk of anti‐tuberculosis drug‐induced hepatotoxicity: A systematic review and meta‐analysis

2020 ◽  
Vol 8 (6) ◽  
Author(s):  
Miaomiao Yang ◽  
Yunliang Qiu ◽  
Yanyu Jin ◽  
Wenpei Liu ◽  
Qingliang Wang ◽  
...  
Keyword(s):  
Systematic Review ◽  
Genetic Polymorphisms ◽  
Meta Analysis ◽  
Drug Induced

scholarly journals Association of genetic polymorphisms of CYP2E1, NAT2, GST and SLCO1B1 with the risk of anti-tuberculosis drug-induced liver injury: a systematic review and meta-analysis

BMJ Open ◽  
2019 ◽  
Vol 9 (8) ◽  
pp. e027940 ◽  
Author(s):  
Seungwon Yang ◽  
Se Jung Hwang ◽  
Jung Yun Park ◽  
Eun Kyoung Chung ◽  
Jangik I Lee
Keyword(s):  
Systematic Review ◽  
Liver Injury ◽  
Genetic Polymorphisms ◽  
Fixed Effects ◽  
Meta Analysis ◽  
Organic Anion ◽  
Close Monitoring ◽  
Drug Induced ◽  
Slow Acetylator ◽  
Drug Induced Liver Injury

ObjectivesThe objective of this study was to investigate the association between genetic polymorphisms of N-acetyltransferase 2 (NAT2), cytochrome P450 2E1 (CYP2E1), glutathione S-transferase (GST) and solute carrier organic anion transporter family member 1B1 (SLCO1B1) and the risk of anti-tuberculosis drug-induced liver injury (ATDILI).DesignSystematic review and meta-analysis.Data sourcesPubMed, Embase, Web of Science and Cochrane Reviews databases were searched through April 2019.Eligibility criteriaWe included case-control or cohort studies investigating an association between NAT2, CYP2E1, GST or SLCO1B1 polymorphisms and the ATDILI risk in patients with tuberculosis.Data extraction and synthesisThree authors screened articles, extracted data and assessed study quality. The strength of association was evaluated for each gene using the pooled OR with a 95% CI based on the fixed-effects or random-effects model. Sensitivity analysis was performed to confirm the reliability and robustness of the results.ResultsFifty-four studies were included in this analysis (n=26 for CYP2E1, n=35 for NAT2, n=19 for GST, n=4 for SLCO1B1). The risk of ATDILI was significantly increased with the following genotypes: CYP2E1 RsaI/PstI c1/c1 (OR=1.39, 95% CI 1.06 to 1.83), NAT2 slow acetylator (OR=3.30, 95% CI 2.65 to 4.11) and GSTM1 null (OR=1.30, 95% CI 1.12 to 1.52). No significant association with ATDILI was found for the genetic polymorphisms of CYP2E1 DraI, GSTT1, GSTM1/GSTT1, SLCO1B1 388A>G and SLCO1B1 521T>C (p>0.05).ConclusionsATDILI is more likely to occur in patients with NAT2 slow acetylator genotype, CYP2E1 RsaI/PstI c1/c1 genotype and GSTM1 null genotype. Close monitoring may be warranted for patients with these genotypes.

scholarly journals Prevention and management of idiosyncratic drug-induced liver injury: Systematic review and meta-analysis of randomised clinical trials

2021 ◽  
Vol 164 ◽  
pp. 105404
Author(s):  
Hao Niu ◽  
Judith Sanabria-Cabrera ◽  
Ismael Alvarez-Alvarez ◽  
Mercedes Robles-Diaz ◽  
Simona Stankevičiūtė ◽  
...  
Keyword(s):  
Systematic Review ◽  
Clinical Trials ◽  
Liver Injury ◽  
Meta Analysis ◽  
Randomised Clinical Trials ◽  
Drug Induced ◽  
Drug Induced Liver Injury

scholarly journals The toxic effects of chloroquine and hydroxychloroquine on skeletal muscle: a systematic review and meta-analysis

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Claudia Cristina Biguetti ◽  
Joel Ferreira Santiago Junior ◽  
Matthew William Fiedler ◽  
Mauro Toledo Marrelli ◽  
Marco Brotto
Keyword(s):  
Systematic Review ◽  
Quantitative Analysis ◽  
Qualitative Analysis ◽  
Observational Studies ◽  
Skeletal Muscles ◽  
Case Reports ◽  
Meta Analysis ◽  
Toxic Effects ◽  
Drug Induced ◽  
Qualitative And Quantitative

AbstractThe aim of this systematic review was to perform qualitative and quantitative analysis on the toxic effects of chloroquine (CQ) and hydroxychloroquine (HCQ) on skeletal muscles. We designed the study according to PRISMA guidelines. Studies for qualitative and quantitative analyses were selected according to the following inclusion criteria: English language; size of sample (> 5 patients), adult (> age of 18) patients, treated with CQ/HCQ for inflammatory diseases, and presenting and not presenting with toxic effects on skeletal muscles. We collected data published from 1990 to April 2020 using PubMed, Cochrane Library, EMBASE, and SciELO. Risk of bias for observational studies was assessed regarding the ROBIN-I scale. Studies with less than five patients (case reports) were selected for an additional qualitative analysis. We used the software Comprehensive Meta-Analysis at the confidence level of 0.05. We identified 23 studies for qualitative analysis (17 case-reports), and five studies were eligible for quantitative analysis. From case reports, 21 patients presented muscle weakness and confirmatory biopsy for CQ/HCQ induced myopathy. From observational studies, 37 patients out of 1,367 patients from five studies presented muscle weakness related to the use of CQ/HCQ, and 252 patients presented elevated levels of muscle enzymes (aldolase, creatine phosphokinase, and lactate dehydrogenase). Four studies presented data on 34 patients with confirmatory biopsy for drug-induced myopathy. No study presented randomized samples. The chronic use of CQ/HCQ may be a risk for drug-induced myopathy. There is substantiated need for proper randomized trials and controlled prospective studies needed to assess the clinical and subclinical stages of CQ/HCQ -induced muscle myopathy.

scholarly journals Association of the genetic polymorphisms in inhibiting and activating molecules of immune system with rheumatoid arthritis: A systematic review and meta-analysis

2021 ◽  
Vol 26 (1) ◽  
pp. 22
Author(s):  
Nima Rezaei ◽  
MohammadJavad Mousavi ◽  
MohammadReza Hooshangi Shayesteh ◽  
Sirous Jamalzehi ◽  
Reza Alimohammadi ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Systematic Review ◽  
Immune System ◽  
Genetic Polymorphisms ◽  
Meta Analysis

scholarly journals Drug-induced sedation endoscopy (DISE) classification systems: a systematic review and meta-analysis

2017 ◽  
Vol 21 (4) ◽  
pp. 983-994 ◽  
Author(s):  
Esuabom Dijemeni ◽  
Gabriele D’Amone ◽  
Israel Gbati
Keyword(s):  
Systematic Review ◽  
Meta Analysis ◽  
Classification Systems ◽  
Drug Induced

Sa1558 Risk of Non-Steroidal Anti-Inflammatory Drugs-Related Serious Drug-Induced Liver Injury: A Systematic Review and Meta-Analysis

2016 ◽  
Vol 150 (4) ◽  
pp. S1066
Author(s):  
Sakkarin Chirapongsathorn ◽  
Chayakrit Krittanawong ◽  
Ann M. Farrell ◽  
Mohammad H. Murad ◽  
Patrick Kamath
Keyword(s):  
Systematic Review ◽  
Liver Injury ◽  
Meta Analysis ◽  
Drug Induced ◽  
Drug Induced Liver Injury ◽  
Inflammatory Drugs ◽  
Anti Inflammatory

Genetic polymorphisms and response to medications for alcohol use disorders: a systematic review and meta-analysis

2014 ◽  
Vol 15 (13) ◽  
pp. 1687-1700 ◽  
Author(s):  
Daniel E Jonas ◽  
Halle R Amick ◽  
Cynthia Feltner ◽  
Roberta Wines ◽  
Ellen Shanahan ◽  
...  
Keyword(s):  
Systematic Review ◽  
Alcohol Use ◽  
Genetic Polymorphisms ◽  
Meta Analysis ◽  
Alcohol Use Disorders

Human papillomavirus and host genetic polymorphisms in carcinogenesis: A systematic review and meta-analysis

2014 ◽  
Vol 61 (2) ◽  
pp. 220-229 ◽  
Author(s):  
Steven Habbous ◽  
Vincent Pang ◽  
Wei Xu ◽  
Eitan Amir ◽  
Geoffrey Liu
Keyword(s):  
Systematic Review ◽  
Human Papillomavirus ◽  
Genetic Polymorphisms ◽  
Meta Analysis ◽  
Host Genetic
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