scholarly journals In vitro and in vivo human metabolism and pharmacokinetics of S‐ and R‐praziquantel

2020 ◽  
Vol 8 (4) ◽  
Author(s):  
Nyasha Nicole Kapungu ◽  
Xueqing Li ◽  
Charles Nhachi ◽  
Collen Masimirembwa ◽  
Roslyn Stella Thelingwani
Keyword(s):  
Human Metabolism

scholarly journals Microdialysis of skeletal muscle at rest

1999 ◽  
Vol 58 (4) ◽  
pp. 919-923 ◽  
Author(s):  
Jan Henriksson
Keyword(s):  
Skeletal Muscle ◽  
Blood Flow ◽  
Human Skeletal Muscle ◽  
Human Metabolism ◽  
High Expectations ◽  
Perfusate Flow ◽  
Muscle Research ◽  
Interstitial Glucose

Techniques in human skeletal muscle research are by necessity predominantly 'descriptive'.Microdialysis has raised high expectations that it could meet the demand for a method that allows 'mechanistic' investigations to be performed in human skeletal muscle. In the present review, some views are given on how well the initial expectations on the use of the microdialysis technique in skeletal muscle have been fulfilled, and the areas in which additional work is needed in order to validate microdialysis as an important metabolic technique in this tissue. The microdialysis catheter has been equated to an artificial blood vessel, which is introduced into the tissue. By means of this 'vessel' the concentrations of compounds in the interstitial space can be monitored. The concentration of substances in the collected samples is dependent on the rate of perfusate flow. When perfusate flow is slow enough to allow complete equilibration between interstitial and perfusate fluids, the concentration in the perfusate is maximal and identical to the interstitial concentration. Microdialysis data may be influenced by changes in blood flow, especially in instances where the tissue diffusivity limits the recovery in vivo, i.e. when recovery in vitro is 100 %, whereas the recovery in vivo is less than 100 %. Microdialysis data indicate that a significant arterial-interstitial glucose concentration gradient exists in skeletal muscle but not in adipose tissue at rest. While the concentrations of glucose and lactate in the dialysate from skeletal muscle are close to the expected values, the glycerol values obtained for muscle are still puzzling. Ethanol added to the perfusate will be cleared by the tissue at a rate that is determined by the nutritive blood flow (the microdialysis ethanol technique). It is concluded that microdialysis of skeletal muscle has become an important technique for mechanistic studies in human metabolism and nutrition.

In vitro and in vivo human metabolism of a synthetic cannabinoid EAM-2201 detected by LC–quadrupole-ion trap-MS/MS and high-resolution LC–Orbitrap-MS/MS

2019 ◽  
Vol 37 (2) ◽  
pp. 432-442 ◽  
Author(s):  
Kayoko Minakata ◽  
Itaru Yamagishi ◽  
Koutaro Hasegawa ◽  
Hideki Nozawa ◽  
Masako Suzuki ◽  
...  
Keyword(s):  
High Resolution ◽  
Ion Trap ◽  
Quadrupole Ion Trap ◽  
Synthetic Cannabinoid ◽  
Human Metabolism ◽  
Orbitrap Ms

Different in vitro and in vivo tools for elucidating the human metabolism of alpha-cathinone-derived drugs of abuse

2018 ◽  
Vol 10 (7) ◽  
pp. 1119-1130 ◽  
Author(s):  
Sascha K. Manier ◽  
Lilian H.J. Richter ◽  
Jan Schäper ◽  
Hans H. Maurer ◽  
Markus R. Meyer
Keyword(s):  
Drugs Of Abuse ◽  
Human Metabolism

scholarly journals In vitro and in vivo human metabolism of a new synthetic cannabinoid NM-2201 (CBL-2201)

2016 ◽  
Vol 35 (1) ◽  
pp. 20-32 ◽  
Author(s):  
Xingxing Diao ◽  
Jeremy Carlier ◽  
Mingshe Zhu ◽  
Shaokun Pang ◽  
Robert Kronstrand ◽  
...  
Keyword(s):  
Synthetic Cannabinoid ◽  
Human Metabolism

scholarly journals In vitro and in vivo Human Metabolism of (S)-[18F]Fluspidine – A Radioligand for Imaging σ1 Receptors With Positron Emission Tomography (PET)

2019 ◽  
Vol 10 ◽  
Author(s):  
Friedrich-Alexander Ludwig ◽  
Steffen Fischer ◽  
Richard Houska ◽  
Alexander Hoepping ◽  
Winnie Deuther-Conrad ◽  
...  
Keyword(s):  
Positron Emission Tomography ◽  
Emission Tomography ◽  
Human Metabolism ◽  
Positron Emission

scholarly journals In Vitro and In Vivo Human Metabolism of Synthetic Cannabinoids FDU-PB-22 and FUB-PB-22

2016 ◽  
Vol 18 (2) ◽  
pp. 455-464 ◽  
Author(s):  
Xingxing Diao ◽  
Karl B. Scheidweiler ◽  
Ariane Wohlfarth ◽  
Shaokun Pang ◽  
Robert Kronstrand ◽  
...  
Keyword(s):  
Synthetic Cannabinoids ◽  
Human Metabolism

Minipig and Human Metabolism of Aldehyde Oxidase Substrates: In Vitro–In Vivo Comparisons

2017 ◽  
Vol 19 (4) ◽  
pp. 1163-1174 ◽  
Author(s):  
David J. Wilkinson ◽  
Rosalind L. Southall ◽  
Mingguang Li ◽  
Lisa M. Wright ◽  
Lindsay J. Corfield ◽  
...  
Keyword(s):  
Aldehyde Oxidase ◽  
Human Metabolism
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