scholarly journals Prescribing trend in cardiovascular patients at Ethiopian university hospital: The number of medications and implication on the clinical improvement

2019 ◽  
Vol 7 (3) ◽  
pp. e00474 ◽  
Author(s):  
Yonas G. Tefera ◽  
Tamrat B. Abebe ◽  
Abebe B. Mekuria ◽  
Misganaw S. Kelkay ◽  
Tadesse M. Abegaz
Keyword(s):  
Clinical Improvement ◽  
University Hospital ◽  
Cardiovascular Patients ◽  
Prescribing Trend

scholarly journals Impaired cardiac function is associated with mortality in patients with acute COVID-19 infection

2020 ◽  
Vol 109 (12) ◽  
pp. 1491-1499 ◽  
Author(s):  
Dominik Rath ◽  
Álvaro Petersen-Uribe ◽  
Alban Avdiu ◽  
Katja Witzel ◽  
Philippa Jaeger ◽  
...  
Keyword(s):  
Cardiac Function ◽  
Poor Prognosis ◽  
Troponin I ◽  
Left Ventricular ◽  
University Hospital ◽  
Severe Respiratory Distress ◽  
Cardiovascular Patients ◽  
Cardiovascular Evaluation ◽  
The University ◽  
Impaired Cardiac Function

Abstract Background COVID-19 infection may cause severe respiratory distress and is associated with increased morbidity and mortality. Impaired cardiac function and/or pre-existing cardiovascular disease may be associated with poor prognosis. In the present study, we report a comprehensive cardiovascular characterization in the first consecutive collective of patients that was admitted and treated at the University Hospital of Tübingen, Germany. Methods 123 consecutive patients with COVID-19 were included. Routine blood sampling, transthoracic echocardiography and electrocardiography were performed at hospital admission. Results We found that impaired left-ventricular and right-ventricular function as well as tricuspid regurgitation > grade 1 were significantly associated with higher mortality. Furthermore, elevated levels of myocardial distress markers (troponin-I and NT pro-BNP) were associated with poor prognosis in this patient collective. Conclusion Impaired cardiac function is associated with poor prognosis in COVID-19 positive patients. Consequently, treatment of these patients should include careful guideline-conform cardiovascular evaluation and treatment. Thus, formation of a competent Cardio-COVID-19 team may represent a major clinical measure to optimize therapy of cardiovascular patients during this pandemic.

Evaluation von Messmethoden zur Erfassung der Durchblutung bei chronischer kritischer Extremitätenischämie

VASA ◽  
2002 ◽  
Vol 31 (3) ◽  
pp. 173-178 ◽  
Author(s):  
Zwicky ◽  
Mahler ◽  
Baumgartner
Keyword(s):  
Clinical Improvement ◽  
Clinical Course ◽  
Limb Ischemia ◽  
University Hospital ◽  
Poor Correlation ◽  
Capillary Microscopy ◽  
Chronic Critical Limb Ischemia ◽  
Group 2 ◽  
The University

Background: Evaluation of macro- and microcirculatory tests to confirm diagnosis, and recognize perfusion changes in chronic critical limb ischemia (CLI). Patients and methods: Forty-two consecutive patients with CLI examined at the University Hospital Bern, with 21 included in this prospective follow-up analysis. Patients underwent serial clinical examinations, and assessment of the macro- (ankle arterial pressure [AP], great toe pressure [TP], oscillography) and microcirculation (transcutaneous partial oxygen pressure [tcPO2] recumbent, sitting, O2-inhalation; capillary microscopy) at baseline, 6 weeks after revascularization (group 1; [n = 11]), or after 10 weeks in patients unsuitable for revascularization (group 2; [n = 10]). Clinical improvement was considered to indicate increased perfusion. Results: Eleven patients with revascularization (11/11), and 2 without revascularization (2/10) showed clinical improvement. AP measurements were not reliable or feasible in 9 (43%), TP in 4 patients (19%), respectively. All measurable pressures were in accordance to clinical course. Oszillography gave a moderate perception of perfusion changes. Baseline tcPO2 levels were critical (< 30 mmHg) in all 21 patients, whereas follow-up gave poor correlation with the clinical course. Reliability to detect perfusion changes increased by adding provocation manoeuvers in patients with clinical improvement (39% [5/13] recumbent, 77% [10/13] sitting, 85% [11/13] O2-inhalation). Capillary microscopy revealed a relevant pathology at the forefoot level in all patients with feasible examinations (18/21), and significant improvements according to the clinical course in 92% of patients (12/13). Conclusions: TP measurements represented most reliable test to confirm diagnosis and disclose improved perfusion in CLI. TcPO2 measurements in recumbent position gave unreliable results, improved by provocation manoeuvers. Capillary microscopy was reliable, but time consuming and limited by anatomical restrictions.

scholarly journals Rationale for COVID-19 Treatment by Nebulized Interferon-β-1b–Literature Review and Personal Preliminary Experience

2020 ◽  
Vol 11 ◽  
Author(s):  
Aurélien Mary ◽  
Lucie Hénaut ◽  
Pierre Yves Macq ◽  
Louise Badoux ◽  
Arnaud Cappe ◽  
...  
Keyword(s):  
Side Effects ◽  
Clinical Improvement ◽  
The United States ◽  
University Hospital ◽  
Inhalation Therapy ◽  
Type I ◽  
Intensive Care Patients ◽  
Significant Clinical Improvement ◽  
Systemic Side Effects ◽  
Set Up

The inflammatory response to COVID-19 is specifically associated with an impaired type I interferon (IFN) response and complete blockade of IFN-β secretion. Clinically, nebulization of IFN-α-2b has been historically used in China to treat viral pneumonia associated with SARS-CoV. Very recent data show that the use of inhaled type I IFN is associated with decreased mortality in Chinese COVID-19 patients. However, IFN nebulization is currently not standard in Europe and the United States. Therefore, our group has set up a project aimed to evaluate the possibility to nebulize IFN-β-1b (a drug currently used in Europe to treat multiple sclerosis via subcutaneous injections) and to assess the safety of this new mode of administration in SARS-CoV-2 infected patients. We present here literature data that allowed us to build our hypothesis and to develop collaboration between clinical pharmacists, intensivists and nebulization engineers in order to gain first pre-clinical and clinical experience of IFN-β-1b nebulization. After validation of the nebulization method and verification of droplet size compatible with nebulization, the method has been applied to four intensive care patients treated at our university hospital, for whom none of the COVID-19 therapies initially used in France led to significant clinical improvement. All patients exhibited negative viral carriage and experienced clinical improvement 7–16 days after having initiated nebulized IFN-β-1b inhalation therapy. No side effects were observed. All patients were alive within a 90-days follow-up. Although it is not possible to draw firm conclusions on treatment efficacy based on this case report, our study shows that pulmonary IFN-β-1b administration is feasible, with a good safety profile. This procedure, which presents the advantage of directly targeting the lungs and reducing the risks of systemic side effects, may represent a promising therapeutic strategy for the care of patients with severe COVID-19. However, our preliminary observation requires confirmation by randomized controlled trials.

scholarly journals Olfaction in Primary Atrophic Rhinitis and Effect of Treatment

OTO Open ◽  
2020 ◽  
Vol 4 (3) ◽  
pp. 2473974X2094950
Author(s):  
Anupam Mishra ◽  
Nimisha Mishra Shukla ◽  
Veerendra Verma ◽  
Subhash Chandra Mishra
Keyword(s):  
Clinical Improvement ◽  
Care Center ◽  
Surrogate Marker ◽  
Neck Surgery ◽  
Clinical Severity ◽  
University Hospital ◽  
Atrophic Rhinitis ◽  
Clinical Parameters ◽  
Severity Of Disease ◽  
Systemic Pathology

Objective To assess olfactory and clinical morbidity in primary (idiopathic)–type atrophic rhinitis and its course following treatment. Study Design Prospective nonrandomized controlled cohort study with follow-up. Setting Department of Otorhinolaryngology and Head and Neck Surgery of a university hospital (tertiary heath care center). Methods Sixty-one patients with atrophic rhinitis underwent assessment of clinical severity with baseline olfaction with the Brief Smell Identification test, while the improvement of their status following surgical versus nonsurgical treatment was further assessed. Results Olfaction was universally deranged with bimodal age presentation and female predominance (61%). Clinical improvement was significantly associated with surgical treatment but did not reveal any relation with up-front severity of disease. A near-significant association of age with severity did not reveal significance when stratified by age group. Baseline olfaction or its change following treatment did not reveal any significance with severity of disease or clinical improvement. Radiologic atrophy also did not reveal any significant relation with severity criteria. Conclusions Olfactory functions as compared with clinical parameters provided better reflection of underlying (systemic) pathology with environmental interaction, while later it mainly signified localized condition. Accordingly, olfaction was affected early and recovered slowly (or not at all), independent of clinical morbidity, which in turn is affected rather late but recovers early. Olfactory dysfunction at the initial stage may be a surrogate marker of potential worsening clinical condition, since bacteria often superinfect underlying susceptible nasal environment. While surgery mainly improved clinical parameters without affecting olfaction directly, a true improvement would include recovery of both.

scholarly journals Life Events and Adaptive Coping Approaches to Self-Management From the Perspectives of Hospitalized Cardiovascular Patients: A Qualitative Study

2021 ◽  
Vol 12 ◽  
Author(s):  
Ruolin Qiu ◽  
Leiwen Tang ◽  
Xiyi Wang ◽  
Zhihong Ye
Keyword(s):  
Qualitative Study ◽  
Life Events ◽  
Sampling Procedure ◽  
Stressful Events ◽  
University Hospital ◽  
Self Management ◽  
Psychological Resilience ◽  
Adaptive Coping ◽  
Structured Interviews ◽  
Cardiovascular Patients

Objectives: This study aimed to explore the association between hospitalized cardiovascular patients' life events and adaptive coping approaches to self-management.Methods: The study was a qualitative study that was conducted in a cardiology department of one affiliated university hospital in Hangzhou, China. Twenty-eight participants with cardiovascular diseases were recruited through a purposive sampling procedure. Semi-structured interviews were used to gain insights into adaptive coping approaches to self-management when living with different life events. Interviews were audio-recorded and transcribed, and the data were analyzed by thematic analysis.Results: Life events reported by hospitalized cardiovascular participants could be summarized in four categories: daily routines, life changes, life-threatening experiences, and emotional sufferings. The adaptive coping approaches were also summarized in four themes: decision-making, avoidance, consistent responses, and episodic responses.Conclusion: This study described essential insights into the mutual influences between various life events and adaptive coping approaches to self-management by a group of hospitalized cardiovascular patients. Participants coped with their problems flexibly by processing comprehensive information from various and unpredictable life events regarding the situations and contexts. While inequity was cumulated, psychological resilience was a vital mediator between stressful events and their responses. The study illuminated the importance of understanding context, situations, and experiences on how cardiovascular patients adapted to their self-management regimens.

scholarly journals Performa Klasifikasi K-NN dan Cross Validation Pada Data Pasien Pengidap Penyakit Jantung

2020 ◽  
Vol 12 (2) ◽  
pp. 81-86
Author(s):  
Huzain Azis ◽  
Purnawansyah Purnawansyah ◽  
Farniwati Fattah ◽  
Inggrianti Pratiwi Putri
Keyword(s):  
Heart Failure ◽  
Cardiovascular Disease ◽  
Cross Validation ◽  
University Hospital ◽  
Research Results ◽  
A Value ◽  
Cardiovascular Patient ◽  
Cardiovascular Patients ◽  
K 13 ◽  
F Measure

Globally, the number one cause of death each year is cardiovascular disease. Cardiovascular disease is a disease caused by impaired function of the heart and blood vessels, such as coronary heart disease, heart failure or heart failure, hypertension and stroke. The purpose of this study was to measure the performance of accuracy, precision, recall and f-measure of the K-NN and Crossvalidation methods on a dataset of cardiovascular patients. The dataset used was 1000 records consisting of 11 attributes (age, gender, height, etc.) cardiovascular and non cardiovascular patient data, the dataset was obtained from the UCI Machine Learning Repository managed by the Hungarian Institute of Cardiology Budapest: Andras Janosi, MD, University Hospital, Zurich, Switzerland. The steps taken are: dividing the simulation ratio of the dataset to 20:80, 50:50 and 80:20, applying crossvalidation (k-fold = 10) and classification using the K-NN method (k = 2 to K = 900). The research results from the simulation of the dataset ratio 50:50 obtained an accuracy value of 82%, 82% precision, 82% recall and 80% f-measure at a value of K = 13, then the research results from the simulation of the dataset ratio 20:80 obtained an accuracy value of 87%, 87% precision, 97% recall and 92% f-measure at the value of K = 3, and the results of research from the simulation of the dataset ratio 80:20 obtained an accuracy value of 91%, 92% precision, 60% recall and 72% f-measure at the value K = 5.

scholarly journals Prevalence and determinants of polypharmacy in cardiovascular patients attending outpatient clinic in Ethiopia University Hospital

PLoS ONE ◽  
2020 ◽  
Vol 15 (6) ◽  
pp. e0234000
Author(s):  
Yonas Getaye Tefera ◽  
Mekuriaw Alemayehu ◽  
Gashaw Binega Mekonnen
Keyword(s):  
Outpatient Clinic ◽  
University Hospital ◽  
Cardiovascular Patients

An Ultrastructural Study of the Proliferation Patterns of the Reserve Cells of the Human Cervix Uteri

1972 ◽  
Vol 30 ◽  
pp. 80-81
Author(s):  
Takanori Sohda ◽  
Hiroshi Saito ◽  
Goro Asano ◽  
Katsunari Fukushi ◽  
Katsuya Suzuki ◽  
...  
Keyword(s):  
Ultrastructural Study ◽  
Age Groups ◽  
Point Of View ◽  
University Hospital ◽  
Cervix Uteri ◽  
Morphological Aspect ◽  
Functional Aspect ◽  
Pathological Conditions ◽  
Human Cervix ◽  
Morphological Patterns

Recently, the functional aspect as well as morphological aspect of the reserve cells in the cervix uteri drew much attention in view of the carcinogenesis in squamocolumunar junction. In this communication, the authors elucidate the ultrastructural features of the reserve cells in patients of various age groups visiting our university hospital and affiliated hospital.From conventional light microscopic point of view, the reserve cells tend to be pronounced in various pathological conditions, such as the persisting inflammation, proliferative disorders and irritation of hormones. The morphological patterns of the reserve cells from various stage and degree of irritation were observed.

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