scholarly journals T-type voltage-gated Ca2+channels do not contribute to the negative feedback regulation of myogenic tone in murine superior epigastric arteries

2017 ◽  
Vol 5 (3) ◽  
pp. e00320 ◽  
Author(s):  
Brendan Mullan ◽  
Jessica Pettis ◽  
William F. Jackson
Keyword(s):  
Negative Feedback ◽  
Feedback Regulation ◽  
Myogenic Tone ◽  
Negative Feedback Regulation ◽  
Voltage Gated ◽  
Ca2 Channels ◽  
Epigastric Arteries

scholarly journals Calcium-Dependent Ion Channels and the Regulation of Arteriolar Myogenic Tone

2021 ◽  
Vol 12 ◽  
Author(s):  
William F. Jackson
Keyword(s):  
Blood Pressure ◽  
Ion Channels ◽  
Negative Feedback ◽  
Transient Receptor Potential ◽  
Feedback Regulation ◽  
Receptor Potential ◽  
Myogenic Tone ◽  
Negative Feedback Regulation ◽  
Voltage Gated ◽  
Transient Receptor

Arterioles in the peripheral microcirculation regulate blood flow to and within tissues and organs, control capillary blood pressure and microvascular fluid exchange, govern peripheral vascular resistance, and contribute to the regulation of blood pressure. These important microvessels display pressure-dependent myogenic tone, the steady state level of contractile activity of vascular smooth muscle cells (VSMCs) that sets resting arteriolar internal diameter such that arterioles can both dilate and constrict to meet the blood flow and pressure needs of the tissues and organs that they perfuse. This perspective will focus on the Ca2+-dependent ion channels in the plasma and endoplasmic reticulum membranes of arteriolar VSMCs and endothelial cells (ECs) that regulate arteriolar tone. In VSMCs, Ca2+-dependent negative feedback regulation of myogenic tone is mediated by Ca2+-activated K+ (BKCa) channels and also Ca2+-dependent inactivation of voltage-gated Ca2+ channels (VGCC). Transient receptor potential subfamily M, member 4 channels (TRPM4); Ca2+-activated Cl− channels (CaCCs; TMEM16A/ANO1), Ca2+-dependent inhibition of voltage-gated K+ (KV) and ATP-sensitive K+ (KATP) channels; and Ca2+-induced-Ca2+ release through inositol 1,4,5-trisphosphate receptors (IP3Rs) participate in Ca2+-dependent positive-feedback regulation of myogenic tone. Calcium release from VSMC ryanodine receptors (RyRs) provide negative-feedback through Ca2+-spark-mediated control of BKCa channel activity, or positive-feedback regulation in cooperation with IP3Rs or CaCCs. In some arterioles, VSMC RyRs are silent. In ECs, transient receptor potential vanilloid subfamily, member 4 (TRPV4) channels produce Ca2+ sparklets that activate IP3Rs and intermediate and small conductance Ca2+ activated K+ (IKCa and sKCa) channels causing membrane hyperpolarization that is conducted to overlying VSMCs producing endothelium-dependent hyperpolarization and vasodilation. Endothelial IP3Rs produce Ca2+ pulsars, Ca2+ wavelets, Ca2+ waves and increased global Ca2+ levels activating EC sKCa and IKCa channels and causing Ca2+-dependent production of endothelial vasodilator autacoids such as NO, prostaglandin I2 and epoxides of arachidonic acid that mediate negative-feedback regulation of myogenic tone. Thus, Ca2+-dependent ion channels importantly contribute to many aspects of the regulation of myogenic tone in arterioles in the microcirculation.

scholarly journals The Structure of the PanD/PanZ Protein Complex Reveals Negative Feedback Regulation of Pantothenate Biosynthesis by Coenzyme A

2015 ◽  
Vol 22 (4) ◽  
pp. 492-503 ◽  
Author(s):  
Diana C.F. Monteiro ◽  
Vijay Patel ◽  
Christopher P. Bartlett ◽  
Shingo Nozaki ◽  
Thomas D. Grant ◽  
...  
Keyword(s):  
Negative Feedback ◽  
Protein Complex ◽  
Coenzyme A ◽  
Feedback Regulation ◽  
Negative Feedback Regulation ◽  
Pantothenate Biosynthesis

scholarly journals Negative-feedback regulation of ATP release: ATP release from cardiomyocytes is strictly regulated during ischemia

2011 ◽  
Vol 416 (3-4) ◽  
pp. 409-415 ◽  
Author(s):  
Satohiko Kunugi ◽  
Sadahiro Iwabuchi ◽  
Daisuke Matsuyama ◽  
Takaharu Okajima ◽  
Koichi Kawahara
Keyword(s):  
Negative Feedback ◽  
Atp Release ◽  
Feedback Regulation ◽  
Negative Feedback Regulation
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