scholarly journals Deguelin‐induced blockade of PI 3K/protein kinase B/ MAP kinase signaling in zebrafish and breast cancer cell lines is mediated by down‐regulation of fibroblast growth factor receptor 4 activity

2016 ◽  
Vol 4 (2) ◽  
Author(s):  
Wei Wu ◽  
Yang Hai ◽  
Lu Chen ◽  
Rui‐Jin Liu ◽  
Yu‐Xiang Han ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Growth Factor ◽  
Protein Kinase ◽  
Fibroblast Growth Factor ◽  
Breast Cancer Cell ◽  
Fibroblast Growth Factor Receptor ◽  
Protein Kinase B ◽  
Growth Factor Receptor ◽  
Breast Cancer Cell Lines ◽  
Fibroblast Growth

scholarly journals Current Status of Fibroblast Growth Factor Receptor-Targeted Therapies in Breast Cancer

Cells ◽  
2018 ◽  
Vol 7 (7) ◽  
pp. 76 ◽  
Author(s):  
Navid Sobhani ◽  
Anna Ianza ◽  
Alberto D’Angelo ◽  
Giandomenico Roviello ◽  
Fabiola Giudici ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Growth Factor ◽  
Fibroblast Growth Factor ◽  
Fibroblast Growth Factor Receptor ◽  
Growth Factor Receptor ◽  
Metastatic Breast ◽  
Tumor Formation ◽  
Current Status ◽  
Fibroblast Growth ◽  
Fibroblast Growth Factor Receptors

Breast cancer (BC) is the most common malignancy and second only to lung cancer in terms of mortality in women. Despite the incredible progress made in this field, metastatic breast cancer has a poor prognosis. In an era of personalized medicine, there is an urgent need for better knowledge of the biology leading to the disease, which can lead to the design of increasingly accurate drugs against patients’ specific molecular aberrations. Among one of the actionable targets is the fibroblast growth factor receptor (FGFR) pathway, triggered by specific ligands. The Fibroblast Growth Factor Receptors/Fibroblast Growth Factors (FGFRs/FGFs) axis offers interesting molecular targets to be pursued in clinical development. This mini-review will focus on the current knowledge of FGFR mutations, which lead to tumor formation and summarizes the state-of-the-art therapeutic strategies for targeted treatments against the FGFRs/FGFs axis in the context of BC.

Altered intracellular localization of fibroblast growth factor receptor 3 in human breast cancer

2001 ◽  
Vol 194 (1) ◽  
pp. 27-34 ◽  
Author(s):  
Charles Zammit ◽  
Richard Barnard ◽  
Jennifer Gomm ◽  
Rebecca Coope ◽  
S. Shousha ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Growth Factor ◽  
Fibroblast Growth Factor ◽  
Human Breast Cancer ◽  
Fibroblast Growth Factor Receptor ◽  
Intracellular Localization ◽  
Growth Factor Receptor ◽  
Fibroblast Growth ◽  
Human Breast

Targeting fibroblast growth factor receptor in breast cancer: a promise or a pitfall?

2014 ◽  
Vol 18 (6) ◽  
pp. 665-678 ◽  
Author(s):  
Francesca Bedussi ◽  
Alberto Bottini ◽  
Maurizio Memo ◽  
Stephen B Fox ◽  
Sandra Sigala ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Growth Factor ◽  
Fibroblast Growth Factor ◽  
Fibroblast Growth Factor Receptor ◽  
Growth Factor Receptor ◽  
Fibroblast Growth

scholarly journals Fibroblast growth factor receptor 4 (FGFR4) and fibroblast growth factor 19 (FGF19) autocrine enhance breast cancer cells survival

Oncotarget ◽  
2016 ◽  
Vol 7 (36) ◽  
pp. 57633-57650 ◽  
Author(s):  
Kai Hung Tiong ◽  
Boon Shing Tan ◽  
Heng Lungh Choo ◽  
Felicia Fei-Lei Chung ◽  
Ling-Wei Hii ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Growth Factor ◽  
Cancer Cells ◽  
Fibroblast Growth Factor ◽  
Breast Cancer Cells ◽  
Fibroblast Growth Factor Receptor ◽  
Growth Factor Receptor ◽  
Fibroblast Growth ◽  
Fibroblast Growth Factor 19

scholarly journals Impact of fibroblast growth factor receptor 1 (FGFR1) amplification on the prognosis of breast cancer patients

2020 ◽  
Vol 184 (2) ◽  
pp. 311-324
Author(s):  
Ramona Erber ◽  
Matthias Rübner ◽  
Simon Davenport ◽  
Sven Hauke ◽  
Matthias W. Beckmann ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Growth Factor ◽  
Fibroblast Growth Factor ◽  
Fibroblast Growth Factor Receptor ◽  
Statistical Significance ◽  
Growth Factor Receptor ◽  
Small Sample ◽  
Fibroblast Growth ◽  
Luminal B ◽  
The Impact

Abstract Purpose Various aberrations in the fibroblast growth factor receptor genes FGFR1, FGFR2, and FGFR3 are found in different cancers, including breast cancer (BC). This study analyzed the impact of FGFR amplification on the BC prognosis. Methods The study included 894 BC patients. The amplification rates of FGFR1, FGFR2, and FGFR3 were evaluated on tissue microarrays using fluorescence in situ hybridization (FISH). Associations between these parameters and prognosis were analyzed using multivariate Cox regression analyses. Results FGFR1 FISH was assessable in 503 samples, FGFR2 FISH in 447, and FGFR3 FISH in 562. The FGFR1 amplification rate was 6.6% (n = 33). Increased FGFR2 copy numbers were seen in 0.9% (n = 4); only one patient had FGFR3 amplification (0.2%). Most patients with FGFR1 amplification had luminal B-like tumors (69.7%, n = 23); only 32.6% (n = 153) of patients without FGFR1 amplification had luminal B-like BC. Other patient and tumor characteristics appeared similar between these two groups. Observed outcome differences between BC patients with and without FGFR1 amplification did not achieve statistical significance; however, there was a trend toward poorer distant metastasis-free survival in BC patients with FGFR1 amplification (HR = 2.08; 95% CI 0.98 to 4.39, P = 0.05). Conclusion FGFR1 amplification occurs most frequently in patients with luminal B-like BC. The study showed a nonsignificant correlation with the prognosis, probably due to the small sample size. Further research is therefore needed to address the role of FGFR1 amplifications in early BC patients. FGFR2 and FGFR3 amplifications are rare in patients with primary BC.

Sign in / Sign up

Export Citation Format

Share Document