Structure and dynamics of the Somatostatin receptor 3 ( SSTR3 )‐ligand binding in presence of lipids examined using computational structural biology methods

2021 ◽  
Author(s):  
Santhosh Kumar Nagarajan ◽  
Sathya Babu ◽  
Panneer Devaraju ◽  
Honglae Sohn ◽  
Thirumurthy Madhavan
Keyword(s):  
Ligand Binding ◽  
Structural Biology ◽  
Somatostatin Receptor ◽  
Structure And Dynamics ◽  
Computational Structural Biology

scholarly journals Molecular-Level Understanding of the Somatostatin Receptor 1 (SSTR1)–Ligand Binding: A Structural Biology Study Based on Computational Methods

ACS Omega ◽  
2020 ◽  
Vol 5 (33) ◽  
pp. 21145-21161
Author(s):  
Santhosh Kumar Nagarajan ◽  
Sathya Babu ◽  
Honglae Sohn ◽  
Thirumurthy Madhavan
Keyword(s):  
Ligand Binding ◽  
Structural Biology ◽  
Computational Methods ◽  
Molecular Level ◽  
Somatostatin Receptor

Computational Structural Biology

10.1142/6659 ◽  
2008 ◽  
Author(s):  
Torsten Schwede ◽  
Manuel C Peitsch
Keyword(s):  
Structural Biology ◽  
Computational Structural Biology

scholarly journals Amino acid physical chemistry furnishes a two-dimensional basis set for computational structural biology

2017 ◽  
Vol 73 (a1) ◽  
pp. a299-a299
Author(s):  
Charles W. Carter ◽  
Richard Wolfenden ◽  
Celia A. Schiffer ◽  
Ronald Swanstrom ◽  
Marc Potempa
Keyword(s):  
Physical Chemistry ◽  
Amino Acid ◽  
Structural Biology ◽  
Basis Set ◽  
Two Dimensional ◽  
Computational Structural Biology

scholarly journals Recent Advances in Structure, Function, and Pharmacology of Class A Lipid GPCRs: Opportunities and Challenges for Drug Discovery

2021 ◽  
Vol 15 (1) ◽  
pp. 12
Author(s):  
R. N. V. Krishna Deepak ◽  
Ravi Kumar Verma ◽  
Yossa Dwi Hartono ◽  
Wen Shan Yew ◽  
Hao Fan
Keyword(s):  
Ligand Binding ◽  
Structural Biology ◽  
Drug Targets ◽  
Molecular Mechanisms ◽  
Structural Features ◽  
Structure Based Drug Design ◽  
Bovine Rhodopsin ◽  
Receptor Dynamics ◽  
Ligand Interactions ◽  
Approaches To Study

Great progress has been made over the past decade in understanding the structural, functional, and pharmacological diversity of lipid GPCRs. From the first determination of the crystal structure of bovine rhodopsin in 2000, much progress has been made in the field of GPCR structural biology. The extraordinary progress in structural biology and pharmacology of GPCRs, coupled with rapid advances in computational approaches to study receptor dynamics and receptor-ligand interactions, has broadened our comprehension of the structural and functional facets of the receptor family members and has helped usher in a modern age of structure-based drug design and development. First, we provide a primer on lipid mediators and lipid GPCRs and their role in physiology and diseases as well as their value as drug targets. Second, we summarize the current advancements in the understanding of structural features of lipid GPCRs, such as the structural variation of their extracellular domains, diversity of their orthosteric and allosteric ligand binding sites, and molecular mechanisms of ligand binding. Third, we close by collating the emerging paradigms and opportunities in targeting lipid GPCRs, including a brief discussion on current strategies, challenges, and the future outlook.

Sign in / Sign up

Export Citation Format

Share Document