scholarly journals The amyloid concentric β‐barrel hypothesis: models of Synuclein oligomers, annular protofibrils, lipoproteins, and transmembrane channels

2021 ◽  
Author(s):  
Stewart R. Durell ◽  
H. Robert Guy
Keyword(s):  
Transmembrane Channels

An Ion Transport Switch Based on Light-Responsive Conformation-Dependent G-Quadruplex Transmembrane Channels

2021 ◽  
Author(s):  
Chunying Li ◽  
Hui Chen ◽  
Xiaohai Yang ◽  
Kemin Wang ◽  
Jianbo Liu
Keyword(s):  
Ion Transport ◽  
Selective Transport ◽  
G Quadruplex ◽  
Transmembrane Channels

A light-responsive ion transport switch has been developed based on conformation-dependent azobenzene-incorporated lipophilic G-quadruplex channels, which provides a new smart approach for the selective transport of K+ ions across the...

Heterogeneity in the size and stability of transmembrane channels produced by whole complement

1981 ◽  
Vol 20 (3) ◽  
pp. 287-295 ◽  
Author(s):  
Michael D.P. Boyle ◽  
Adrian P. Gee ◽  
Tibor Borsos
Keyword(s):  
Transmembrane Channels

scholarly journals Aquaporin Channels in the Heart—Physiology and Pathophysiology

2019 ◽  
Vol 20 (8) ◽  
pp. 2039 ◽  
Author(s):  
Arie O. Verkerk ◽  
Elisabeth M. Lodder ◽  
Ronald Wilders
Keyword(s):  
Cardiac Function ◽  
Digestive System ◽  
The Body ◽  
Monovalent Cations ◽  
Biological Functions ◽  
Specific Distribution ◽  
Transmembrane Channels ◽  
Heart Physiology ◽  
Aquaporin Channels ◽  
Coupling Processes

Mammalian aquaporins (AQPs) are transmembrane channels expressed in a large variety of cells and tissues throughout the body. They are known as water channels, but they also facilitate the transport of small solutes, gasses, and monovalent cations. To date, 13 different AQPs, encoded by the genes AQP0–AQP12, have been identified in mammals, which regulate various important biological functions in kidney, brain, lung, digestive system, eye, and skin. Consequently, dysfunction of AQPs is involved in a wide variety of disorders. AQPs are also present in the heart, even with a specific distribution pattern in cardiomyocytes, but whether their presence is essential for proper (electro)physiological cardiac function has not intensively been studied. This review summarizes recent findings and highlights the involvement of AQPs in normal and pathological cardiac function. We conclude that AQPs are at least implicated in proper cardiac water homeostasis and energy balance as well as heart failure and arsenic cardiotoxicity. However, this review also demonstrates that many effects of cardiac AQPs, especially on excitation-contraction coupling processes, are virtually unexplored.

Selective Artificial Transmembrane Channels for Protons by Formation of Water Wires

2011 ◽  
Vol 50 (52) ◽  
pp. 12564-12568 ◽  
Author(s):  
Wen Si ◽  
Lei Chen ◽  
Xiao-Bo Hu ◽  
Gangfeng Tang ◽  
Zhenxia Chen ◽  
...  
Keyword(s):  
Transmembrane Channels

scholarly journals A platform for light-controlled formation of free-stranding lipid membranes

2020 ◽  
Vol 17 (163) ◽  
pp. 20190740 ◽  
Author(s):  
Nikolay V. Ryzhkov ◽  
Ekaterina V. Skorb
Keyword(s):  
Lipid Bilayers ◽  
Lipid Membranes ◽  
Science And Technology Studies ◽  
Separation Distance ◽  
Layer By Layer ◽  
Net Charge ◽  
Novel Approach ◽  
Layer Deposition ◽  
Transmembrane Channels

The engineering of artificial cells is one of the most significant scientific challenges. Thus, controlled fabrication and in situ monitoring of biomimetic nanoscale objects are among the central issues in current science and technology. Studies of transmembrane channels and cell mechanics often require the formation of lipid bilayers (LBs), their modification and their transfer to a particular place. We present here a novel approach for remotely controlled manipulation of LBs. Layer-by-layer deposition of polyethyleneimine and poly(sodium 4-styrenesulfonate) on a nanostructured TiO 2 photoanode was performed to obtain a surface with the desired net charge and to enhance photocatalytic performance. The LB was deposited on top of a multi-layer positive polymer cushion by the dispersion of negative vesicles. The separation distance between the electrostatically linked polyelectrolyte cushion and the LB can be adjusted by changing the environmental pH, as zwitter-ionic lipid molecules undergo pH-triggered charge-shifting. Protons were generated remotely by photoanodic water decomposition on the TiO 2 surface under 365 nm illumination. The resulting pH gradient was characterized by scanning vibrating electrode and scanning ion-selective electrode techniques. The light-induced reversible detachment of the LB from the polymer-cushioned photoactive substrate was found to correlate with suggested impedance models.

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