scholarly journals Geometrical characterization of T cell receptor binding modes reveals class‐specific binding to maximize access to antigen

2019 ◽  
Vol 88 (3) ◽  
pp. 503-513 ◽  
Author(s):  
Nishant K. Singh ◽  
Esam T. Abualrous ◽  
Cory M. Ayres ◽  
Frank Noé ◽  
Ragul Gowthaman ◽  
...  
Keyword(s):  
T Cell ◽  
T Cell Receptor ◽  
Receptor Binding ◽  
Specific Binding ◽  
Cell Receptor ◽  
Binding Modes ◽  
Geometrical Characterization

scholarly journals Characterization of human T cells reactive with the Mycoplasma arthritidis-derived superantigen (MAM): generation of a monoclonal antibody against V beta 17, the T cell receptor gene product expressed by a large fraction of MAM-reactive human T cells.

1991 ◽  
Vol 174 (4) ◽  
pp. 891-900 ◽  
Author(s):  
S M Friedman ◽  
M K Crow ◽  
J R Tumang ◽  
M Tumang ◽  
Y Q Xu ◽  
...  
Keyword(s):  
Monoclonal Antibody ◽  
T Cells ◽  
T Cell ◽  
T Cell Receptor ◽  
Cell Activity ◽  
Cell Receptor ◽  
Cytotoxic T Cell ◽  
Mycoplasma Arthritidis ◽  
Human T Cells

While all known microbial superantigens are mitogenic for human peripheral blood lymphocytes (PBL), the functional response induced by Mycoplasma arthritidis-derived superantigen (MAM) is unique in that MAM stimulation of PBL consistently results in T cell-dependent B cell activation characterized by polyclonal IgM and IgG production. These immunostimulatory effects of MAM on the humoral arm of the human immune system warranted a more precise characterization of MAM-reactive human T cells. Using an uncloned MAM reactive human T cell line as immunogen, we have generated a monoclonal antibody (mAb) (termed C1) specific for the T cell receptor V beta gene expressed by the major fraction of MAM-reactive human T cells, V beta 17. In addition, a V beta 17- MAM-reactive T cell population exists, assessed by MAM, induced T cell proliferation and cytotoxic T cell activity. mAb C1 will be useful in characterizing the functional properties of V beta 17+ T cells and their potential role in autoimmune disease.

scholarly journals Single MHC Mutation Eliminates Enthalpy Associated with T Cell Receptor Binding

2007 ◽  
Vol 373 (2) ◽  
pp. 315-327 ◽  
Author(s):  
Peter J. Miller ◽  
Yael Pazy ◽  
Brian Conti ◽  
David Riddle ◽  
Ettore Appella ◽  
...  
Keyword(s):  
T Cell ◽  
T Cell Receptor ◽  
Receptor Binding ◽  
Cell Receptor

scholarly journals Functional characterization of a T-cell receptor BV6+T-cell clone derived from a leprosy lesion

Immunology ◽  
2007 ◽  
Vol 120 (3) ◽  
pp. 354-361 ◽  
Author(s):  
Shereen Sabet ◽  
Maria-Teresa Ochoa ◽  
Peter A. Sieling ◽  
Thomas H. Rea ◽  
Robert L. Modlin
Keyword(s):  
T Cell ◽  
T Cell Receptor ◽  
Cell Clone ◽  
Functional Characterization ◽  
Cell Receptor ◽  
T Cell Clone

scholarly journals Crystallographic and Mutational Data Show That the Streptococcal Pyrogenic Exotoxin J Can Use a Common Binding Surface for T-cell Receptor Binding and Dimerization

2004 ◽  
Vol 279 (37) ◽  
pp. 38571-38576 ◽  
Author(s):  
Heather M. Baker ◽  
Thomas Proft ◽  
Phillip D. Webb ◽  
Vickery L. Arcus ◽  
John D. Fraser ◽  
...  
Keyword(s):  
T Cell ◽  
T Cell Receptor ◽  
Receptor Binding ◽  
Cell Receptor ◽  
Binding Surface

Mouse autoreactive γ/δ T cells II. Molecular characterization of the T cell receptor

1992 ◽  
Vol 22 (2) ◽  
pp. 491-498 ◽  
Author(s):  
Angel Ezquerra ◽  
David B. Wilde ◽  
Thomas J. McConnell ◽  
Knut Sturmhöfel ◽  
Robert B. Valas ◽  
...  
Keyword(s):  
T Cells ◽  
T Cell ◽  
Molecular Characterization ◽  
T Cell Receptor ◽  
Cell Receptor
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