Structure-based investigation into the functional roles of the extended loop and substrate-recognition sites in an endo-β-1,4-d-mannanase from the Antarctic springtail,Cryptopygus antarcticus

2014 ◽  
Vol 82 (11) ◽  
pp. 3217-3223 ◽  
Author(s):  
Min-Kyu Kim ◽  
Young Jun An ◽  
Jung Min Song ◽  
Chang-Sook Jeong ◽  
Mee Hye Kang ◽  
...  
Keyword(s):  
Substrate Recognition ◽  
Functional Roles ◽  
Recognition Sites ◽  
The Antarctic

Differential Contribution of Active Site Residues in Substrate Recognition Sites 1 and 5 to Cytochrome P450 2C8 Substrate Selectivity and Regioselectivity†

Biochemistry ◽  
2004 ◽  
Vol 43 (24) ◽  
pp. 7834-7842 ◽  
Author(s):  
Oranun Kerdpin ◽  
David J. Elliot ◽  
Sanford L. Boye ◽  
Donald J. Birkett ◽  
Krongtong Yoovathaworn ◽  
...  
Keyword(s):  
Cytochrome P450 ◽  
Active Site ◽  
Substrate Recognition ◽  
Substrate Selectivity ◽  
Active Site Residues ◽  
Recognition Sites ◽  
Cytochrome P450 2C8 ◽  
Differential Contribution

Methylene chain ruler for evaluating the regioselectivity of a substrate-recognising oxidation catalyst

2019 ◽  
Vol 55 (58) ◽  
pp. 8378-8381
Author(s):  
Shota Teramae ◽  
Akane Kito ◽  
Tomoteru Shingaki ◽  
Yu Hamaguchi ◽  
Yuuki Yano ◽  
...  
Keyword(s):  
Substrate Recognition ◽  
Major Product ◽  
Oxidation Catalyst ◽  
Central Position ◽  
Recognition Sites ◽  
Methylene Chain ◽  
Catalysed Oxidation

We designed and synthesised Ru porphyrin 1a as an oxidation catalyst with substrate recognition sites. The 1a catalysed oxidation of substrate 7 selectively oxidised the central position of the methylene chain, affording ketone 8 as the major product.

scholarly journals Extracellular Enzymes and Bioactive Compounds from Antarctic Terrestrial Fungi for Bioprospecting

2020 ◽  
Vol 17 (18) ◽  
pp. 6459
Author(s):  
Laura Zucconi ◽  
Fabiana Canini ◽  
Marta Elisabetta Temporiti ◽  
Solveig Tosi
Keyword(s):  
Bioactive Compounds ◽  
Extracellular Enzymes ◽  
Biological Properties ◽  
Metabolic Potential ◽  
Functional Roles ◽  
Antarctic Soils ◽  
Terrestrial Fungi ◽  
The Antarctic ◽  
Abiotic Environmental Factors

Antarctica, one of the harshest environments in the world, has been successfully colonized by extremophilic, psychrophilic, and psychrotolerant microorganisms, facing a range of extreme conditions. Fungi are the most diverse taxon in the Antarctic ecosystems, including soils. Genetic adaptation to this environment results in the synthesis of a range of metabolites, with different functional roles in relation to the biotic and abiotic environmental factors, some of which with new biological properties of potential biotechnological interest. An overview on the production of cold-adapted enzymes and other bioactive secondary metabolites from filamentous fungi and yeasts isolated from Antarctic soils is here provided and considerations on their ecological significance are reported. A great number of researches have been carried out to date, based on cultural approaches. More recently, metagenomics approaches are expected to increase our knowledge on metabolic potential of these organisms, leading to the characterization of unculturable taxa. The search on fungi in Antarctica deserves to be improved, since it may represent a useful strategy for finding new metabolic pathways and, consequently, new bioactive compounds.

Inhibition of CYP2C8 by metallofullerenol Gd@C82(OH)22 through blocking substrate channels and substrate recognition sites

Carbon ◽  
2018 ◽  
Vol 127 ◽  
pp. 667-675 ◽  
Author(s):  
Dongfang Ma ◽  
Xuan-Yu Meng ◽  
David R. Bell ◽  
Shengtang Liu ◽  
Ruhong Zhou
Keyword(s):  
Substrate Recognition ◽  
Recognition Sites

scholarly journals Factor XIIIa-derived peptides inhibit transglutaminase activity. Localization of substrate recognition sites.

1993 ◽  
Vol 268 (28) ◽  
pp. 21284-21292
Author(s):  
K.E. Achyuthan ◽  
T.F. Slaughter ◽  
M.A. Santiago ◽  
J.J. Enghild ◽  
C.S. Greenberg
Keyword(s):  
Substrate Recognition ◽  
Factor Xiiia ◽  
Transglutaminase Activity ◽  
Recognition Sites
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