scholarly journals Bayesian model aggregation for ensemble-based estimates of protein pKa values

2013 ◽  
Vol 82 (3) ◽  
pp. 354-363 ◽  
Author(s):  
Luke J. Gosink ◽  
Emilie A. Hogan ◽  
Trenton C. Pulsipher ◽  
Nathan A. Baker
Keyword(s):  
Bayesian Model ◽  
Pka Values ◽  
Model Aggregation ◽  
Protein Pka

Very fast empirical prediction and rationalization of protein pKa values

2005 ◽  
Vol 61 (4) ◽  
pp. 704-721 ◽  
Author(s):  
Hui Li ◽  
Andrew D. Robertson ◽  
Jan H. Jensen
Keyword(s):  
Pka Values ◽  
Empirical Prediction ◽  
Protein Pka

scholarly journals pKD: re-designing protein pKa values

2006 ◽  
Vol 34 (Web Server) ◽  
pp. W48-W51 ◽  
Author(s):  
B. M. Tynan-Connolly ◽  
J. E. Nielsen
Keyword(s):  
Pka Values ◽  
Protein Pka

scholarly journals NMR Determination of Protein pKa Values in the Solid State

2010 ◽  
Vol 1 (10) ◽  
pp. 1623-1628 ◽  
Author(s):  
Heather L. Frericks Schmidt ◽  
Gautam J. Shah ◽  
Lindsay J. Sperling ◽  
Chad M. Rienstra
Keyword(s):  
Solid State ◽  
Pka Values ◽  
Protein Pka

scholarly journals Rapid Calculation of Protein pKa Values Using Rosetta

2012 ◽  
Vol 103 (3) ◽  
pp. 587-595 ◽  
Author(s):  
Krishna Praneeth Kilambi ◽  
Jeffrey J. Gray
Keyword(s):  
Pka Values ◽  
Rapid Calculation ◽  
Protein Pka

scholarly journals Redesigning protein pKa values

2006 ◽  
Vol 16 (2) ◽  
pp. 239-249 ◽  
Author(s):  
B. M. Tynan-Connolly ◽  
J. E. Nielsen
Keyword(s):  
Pka Values ◽  
Protein Pka

Evaluating the Validity of a Bayesian Program for Predicting Stage in Hodgkin’s Disease

1981 ◽  
Vol 20 (03) ◽  
pp. 174-178 ◽  
Author(s):  
A. I. Barnett ◽  
J. Cynthia ◽  
F. Jane ◽  
Nancy Gutensohn ◽  
B. Davies
Keyword(s):  
New England ◽  
Hodgkin's Disease ◽  
Bayesian Model ◽  
Medical Center ◽  
Hodgkin’S Disease ◽  
Test Procedure ◽  
Disease Patient ◽  
Probabilistic Information ◽  
Probabilistic Forecasts ◽  
England Medical

A Bayesian model that provides probabilistic information about the spread of malignancy in a Hodgkin’s disease patient has been developed at the Tufts New England Medical Center. In assessing the model’s reliability, it seemed important to use it to make predictions about patients other than those relevant to its construction. The accuracy of these predictions could then be tested statistically. This paper describes such a test, based on 243 Hodgkin’s disease patients of known pathologic stage. The results obtained were supportive of the model, and the test procedure might interest those wishing to determine whether the imperfections that attend any attempt to make probabilistic forecasts have gravely damaged their accuracy.

Machine Learning of Motor Vehicle Accident Categories from Narrative Data

1996 ◽  
Vol 35 (04/05) ◽  
pp. 309-316 ◽  
Author(s):  
M. R. Lehto ◽  
G. S. Sorock
Keyword(s):  
Machine Learning ◽  
Bayesian Model ◽  
Keyword Search ◽  
Motor Vehicle ◽  
Motor Vehicle Accident ◽  
Computer Search ◽  
Vehicle Accident ◽  
Learning Technique ◽  
Expert Ratings ◽  
Keyword Searches

Abstract:Bayesian inferencing as a machine learning technique was evaluated for identifying pre-crash activity and crash type from accident narratives describing 3,686 motor vehicle crashes. It was hypothesized that a Bayesian model could learn from a computer search for 63 keywords related to accident categories. Learning was described in terms of the ability to accurately classify previously unclassifiable narratives not containing the original keywords. When narratives contained keywords, the results obtained using both the Bayesian model and keyword search corresponded closely to expert ratings (P(detection)≥0.9, and P(false positive)≤0.05). For narratives not containing keywords, when the threshold used by the Bayesian model was varied between p>0.5 and p>0.9, the overall probability of detecting a category assigned by the expert varied between 67% and 12%. False positives correspondingly varied between 32% and 3%. These latter results demonstrated that the Bayesian system learned from the results of the keyword searches.

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