scholarly journals The mechanism of the converter domain rotation in the recovery stroke of myosin motor protein

2012 ◽  
Vol 80 (12) ◽  
pp. 2701-2710 ◽  
Author(s):  
Andrij Baumketner
Keyword(s):  
Motor Protein ◽  
Myosin Motor ◽  
Recovery Stroke ◽  
Domain Rotation

scholarly journals The class V myosin motor protein, Myo2, plays a major role in mitochondrial motility in Saccharomyces cerevisiae

2008 ◽  
Vol 181 (1) ◽  
pp. 119-130 ◽  
Author(s):  
Katrin Altmann ◽  
Martina Frank ◽  
Daniel Neumann ◽  
Stefan Jakobs ◽  
Benedikt Westermann
Keyword(s):  
Saccharomyces Cerevisiae ◽  
Actin Cytoskeleton ◽  
Molecular Mechanisms ◽  
Budding Yeast ◽  
Motor Protein ◽  
Mitochondrial Morphology ◽  
Direct Role ◽  
Class V ◽  
Myosin Motor ◽  
Mitochondrial Motility

The actin cytoskeleton is essential for polarized, bud-directed movement of cellular membranes in Saccharomyces cerevisiae and thus ensures accurate inheritance of organelles during cell division. Also, mitochondrial distribution and inheritance depend on the actin cytoskeleton, though the precise molecular mechanisms are unknown. Here, we establish the class V myosin motor protein, Myo2, as an important mediator of mitochondrial motility in budding yeast. We found that mutants with abnormal expression levels of Myo2 or its associated light chain, Mlc1, exhibit aberrant mitochondrial morphology and loss of mitochondrial DNA. Specific mutations in the globular tail of Myo2 lead to aggregation of mitochondria in the mother cell. Isolated mitochondria lacking functional Myo2 are severely impaired in their capacity to bind to actin filaments in vitro. Time-resolved fluorescence microscopy revealed a block of bud-directed anterograde mitochondrial movement in cargo binding–defective myo2 mutant cells. We conclude that Myo2 plays an important and direct role for mitochondrial motility and inheritance in budding yeast.

The Principal Motions Involved in the Coupling Mechanism of the Recovery Stroke of the Myosin Motor

2007 ◽  
Vol 367 (2) ◽  
pp. 591-602 ◽  
Author(s):  
Sidonia Mesentean ◽  
Sampath Koppole ◽  
Jeremy C. Smith ◽  
Stefan Fischer
Keyword(s):  
Coupling Mechanism ◽  
Myosin Motor ◽  
Recovery Stroke

scholarly journals It takes two

eLife ◽  
2015 ◽  
Vol 4 ◽  
Author(s):  
Teresa Nicolson
Keyword(s):  
Hair Cells ◽  
Motor Protein ◽  
Auditory Hair Cells ◽  
Unconventional Myosin ◽  
Myosin Motor ◽  
Hair Bundles

Two forms of an unconventional myosin motor protein have separate functions in the growth and maintenance of hair bundles in auditory hair cells.

Subcellular Analysis of the Motor Protein Apparatus in Ependymal Cilia

2015 ◽  
Vol 46 (S 01) ◽  
Author(s):  
O. Schwartz ◽  
N. Loges ◽  
J. Wallmeier ◽  
G. Dougherty ◽  
P. Pennekamp ◽  
...  
Keyword(s):  
Motor Protein ◽  
Ependymal Cilia
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