scholarly journals Protein domain assignment from the recurrence of locally similar structures

2010 ◽  
Vol 79 (3) ◽  
pp. 853-866 ◽  
Author(s):  
Chin-Hsien Tai ◽  
Vichetra Sam ◽  
Jean-Francois Gibrat ◽  
Jean Garnier ◽  
Peter J. Munson ◽  
...  
Keyword(s):  
Protein Domain ◽  
Domain Assignment

A world-wide web server of protein domain assignment

2005 ◽  
pp. 235-236
Author(s):  
Jing-Chu Luo ◽  
Suhail A. Islam ◽  
Rob. B. Russell ◽  
Michael J.E. Sternberg
Keyword(s):  
World Wide Web ◽  
World Wide ◽  
Web Server ◽  
Protein Domain ◽  
Domain Assignment

scholarly journals Rapid protein domain assignment from amino acid sequence using predicted secondary structure

2009 ◽  
Vol 11 (12) ◽  
pp. 2814-2824 ◽  
Author(s):  
Russell L. Marsden ◽  
Liam J. McGuffin ◽  
David T. Jones
Keyword(s):  
Amino Acid ◽  
Secondary Structure ◽  
Amino Acid Sequence ◽  
Protein Domain ◽  
Domain Assignment

Self-Assembling Micelles Based on an Intrinsically Disordered Protein Domain

2018 ◽  
Author(s):  
Sarah Klass ◽  
Matthew J. Smith ◽  
Tahoe Fiala ◽  
Jessica Lee ◽  
Anthony Omole ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Fusion Proteins ◽  
Organic Molecules ◽  
Intrinsically Disordered Protein ◽  
Protein Domain ◽  
Enzymatic Cleavage ◽  
Intrinsically Disordered ◽  
Disordered Protein ◽  
Self Assembling ◽  
Protein Tag

Herein, we describe a new series of fusion proteins that have been developed to self-assemble spontaneously into stable micelles that are 27 nm in diameter after enzymatic cleavage of a solubilizing protein tag. The sequences of the proteins are based on a human intrinsically disordered protein, which has been appended with a hydrophobic segment. The micelles were found to form across a broad range of pH, ionic strength, and temperature conditions, with critical micelle concentration (CMC) values below 1 µM being observed in some cases. The reported micelles were found to solubilize hydrophobic metal complexes and organic molecules, suggesting their potential suitability for catalysis and drug delivery applications.

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