Three-dimensional model of the human urotensin-II receptor: Docking of human urotensin-II and nonpeptide antagonists in the binding site and comparison with an antagonist pharmacophore model

2008 ◽  
Vol 73 (1) ◽  
pp. 173-184 ◽  
Author(s):  
Elodie Lescot ◽  
Jana Sopkova-de Oliveira Santos ◽  
Nathalie Colloc'h ◽  
Jordi Rodrigo ◽  
Isabelle Milazzo-Segalas ◽  
...  
Keyword(s):  
Binding Site ◽  
Three Dimensional ◽  
Pharmacophore Model ◽  
Urotensin Ii ◽  
Dimensional Model ◽  
Three Dimensional Model

scholarly journals Amino acids important in enzyme activity and dimer stability for Drosophila alcohol dehydrogenase

1995 ◽  
Vol 308 (2) ◽  
pp. 419-423 ◽  
Author(s):  
S W Chenevert ◽  
N G Fossett ◽  
S H Chang ◽  
I Tsigelny ◽  
M E Baker ◽  
...  
Keyword(s):  
Enzyme Activity ◽  
Alcohol Dehydrogenase ◽  
Binding Site ◽  
Aspartic Acid ◽  
Three Dimensional ◽  
Side Chain ◽  
Wild Type ◽  
Dimensional Model ◽  
Three Dimensional Model ◽  
Substrate Binding Site

We have determined the nucleotide sequences of eight ethyl methanesulphonate-induced mutants in Drosophila alcohol dehydrogenase (ADH), of which six were previously characterized by Hollocher and Place [(1988) Genetics 116, 253-263 and 265-274]. Four of these ADH mutants contain a single amino acid change: glycine-17 to arginine, glycine-93 to glutamic acid, alanine-159 to threonine, and glycine-184 to aspartic acid. Although these mutants are inactive, three mutants (Gly17Arg, Gly93Glu and Gly184Asp) form stable homodimers, as well as heterodimers with wild-type ADH, in which the wild-type ADH subunit retains full enzyme activity [Hollocher and Place (1988) Genetics 116, 265-274]. Interestingly, the Ala159Thr mutant does not form either stable homodimers or heterodimers with wild-type ADH, suggesting that alanine-159 is important in stabilizing ADH dimers. The mutations were analysed in terms of a three-dimensional model of ADH using bacterial 20 beta-hydroxysteroid dehydrogenase and rat dihydropteridine reductase as templates. The model indicates that mutations in glycine-17 and glycine-93 affect the binding of NAD+. It also shows that alanine-159 is part of a hydrophobic anchor on the dimer interface of ADH. Replacement of alanine-159 with threonine, which has a larger side chain and can hydrogen bond with water, is likely to reduce the strength of the hydrophobic interaction. The three-dimensional model shows that glycine-184 is close to the substrate binding site. Replacement of glycine-184 with aspartic acid is likely to alter the position of threonine-186, which we propose hydrogen bonds to the carboxamide moiety of NAD+. Also, the negative charge on the aspartic acid side chain may interact with the substrate and/or residues in the substrate binding site. These mutations provide information about ADH catalysis and the stability of dimers, which may also be useful in understanding homologous dehydrogenases, which include the human 17 beta-hydroxysteroid, 11 beta-hydroxysteroid and 15-hydroxyprostaglandin dehydrogenases.

Three-Dimensional Model for Virtual Surgical Simulation, during Complex Skull Base Surgery and Aneurysm Surgery

Skull Base ◽  
2008 ◽  
Vol 18 (S 01) ◽  
Author(s):  
Akio Morita ◽  
Toshikazu Kimura ◽  
Shigeo Sora ◽  
Kengo Nishimura ◽  
Hisayuki Sugiyama ◽  
...  
Keyword(s):  
Skull Base ◽  
Surgical Simulation ◽  
Skull Base Surgery ◽  
Three Dimensional ◽  
Aneurysm Surgery ◽  
Dimensional Model ◽  
Three Dimensional Model

A Variant Group Assignment Three Dimensional Model Using Pattern Recognition Technique

2019 ◽  
Vol 10 (6) ◽  
pp. 1382-1394
Author(s):  
R. Vijayalakshmi ◽  
V. K. Soma Sekhar Srinivas ◽  
E. Manjoolatha ◽  
G. Rajeswari ◽  
M. Sundaramurthy
Keyword(s):  
Pattern Recognition ◽  
Three Dimensional ◽  
Dimensional Model ◽  
Three Dimensional Model ◽  
Pattern Recognition Technique ◽  
Group Assignment ◽  
Recognition Technique

Technology of creating of the unified three-dimensional model of a real estate object

2018 ◽  
Vol 62 (6) ◽  
pp. 659-662
Author(s):  
Korchagina O.A. ◽  
◽  
Trang Nguyen Thuy ◽  
Tevkina A.V. ◽  
◽  
...  
Keyword(s):  
Real Estate ◽  
Three Dimensional ◽  
Dimensional Model ◽  
Three Dimensional Model
Sign in / Sign up

Export Citation Format

Share Document