Assessing the reliability of sequence similarities detected through hydrophobic cluster analysis

2007 ◽  
Vol 70 (4) ◽  
pp. 1588-1594 ◽  
Author(s):  
Pedro J. Silva
Keyword(s):  
Cluster Analysis ◽  
Hydrophobic Cluster Analysis ◽  
Hydrophobic Cluster ◽  
Sequence Similarities

scholarly journals Identification of the catalytic residues of the first family of β(1–3)glucanosyltransferases identified in fungi

2000 ◽  
Vol 347 (3) ◽  
pp. 741-747 ◽  
Author(s):  
Isabelle MOUYNA ◽  
Michel MONOD ◽  
Thierry FONTAINE ◽  
Bernard HENRISSAT ◽  
Barbara LÉCHENNE ◽  
...  
Keyword(s):  
Cluster Analysis ◽  
Active Site ◽  
Biochemical Analysis ◽  
Site Directed Mutagenesis ◽  
Directed Mutagenesis ◽  
Sequence Comparisons ◽  
Catalytic Residues ◽  
Hydrophobic Cluster Analysis ◽  
Hydrophobic Cluster ◽  
New Family

A new family of glycosylphosphatidylinositol-anchored β(1-3)glucanosyltransferases (Gelp), recently identified and characterized in the filamentous fungus Aspergillus fumigatus, showed functional similarity to the Gas/Phr/Epd protein families, which are involved in yeast morphogenesis. Sequence comparisons and hydrophobic cluster analysis (HCA) showed that all the Gas/Phr/Epd/Gel proteins belong to a new family of glycosylhydrolases, family 72. We confirmed by site-directed mutagenesis and biochemical analysis that the two conserved glutamate residues (the putative catalytic residues of this family, as determined by HCA) are involved in the active site of this family of glycosylhydrolases.

Hydrophobic Cluster Analysis Reveals a Third Chromodomain in theTetrahymenaPdd1p Protein of the Chromo Superfamily

1997 ◽  
Vol 235 (1) ◽  
pp. 103-107 ◽  
Author(s):  
Isabelle Callebaut ◽  
Jean-Claude Courvalin ◽  
Howard J. Worman ◽  
Jean-Paul Mornon
Keyword(s):  
Cluster Analysis ◽  
Hydrophobic Cluster Analysis ◽  
Hydrophobic Cluster

Hydrophobic cluster analysis of the primary sequences of α-amylases

1989 ◽  
Vol 11 (4) ◽  
pp. 217-225 ◽  
Author(s):  
E. Raimbaud ◽  
A. Buléon ◽  
S. Perez ◽  
B. Henrissat
Keyword(s):  
Cluster Analysis ◽  
Hydrophobic Cluster Analysis ◽  
Hydrophobic Cluster

Detection of orphan domains in Drosophila using “hydrophobic cluster analysis”

Biochimie ◽  
2015 ◽  
Vol 119 ◽  
pp. 244-253 ◽  
Author(s):  
Tristan Bitard-Feildel ◽  
Magdalena Heberlein ◽  
Erich Bornberg-Bauer ◽  
Isabelle Callebaut
Keyword(s):  
Cluster Analysis ◽  
Hydrophobic Cluster Analysis ◽  
Hydrophobic Cluster

Hydrophobic cluster analysis: a tool for protein modeling

1989 ◽  
Vol 7 (3) ◽  
pp. 171
Author(s):  
L. Lemesle-Varloot ◽  
V. Bissery ◽  
A. Morgat ◽  
C. Gaboriaud ◽  
J.P. Mornon
Keyword(s):  
Cluster Analysis ◽  
Protein Modeling ◽  
Hydrophobic Cluster Analysis ◽  
Hydrophobic Cluster

Hydrophobic cluster analysis (HCA) of the hormone-binding domain of receptor proteins

1989 ◽  
Vol 34 (1-6) ◽  
pp. 355-361 ◽  
Author(s):  
J.P. Mornon ◽  
V. Bissery ◽  
C. Gaboriaud ◽  
A. Thomas ◽  
T. Ojasoo ◽  
...  
Keyword(s):  
Cluster Analysis ◽  
Binding Domain ◽  
Hormone Binding ◽  
Receptor Proteins ◽  
Hydrophobic Cluster Analysis ◽  
Hydrophobic Cluster ◽  
Hormone Binding Domain
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