scholarly journals Structural characterization of the zinc binding domain in cytosolic PSD‐95 interactor (cypin): Role of zinc binding in guanine deamination and dendrite branching

2008 ◽  
Vol 70 (3) ◽  
pp. 873-881 ◽  
Author(s):  
José R. Fernández ◽  
William J. Welsh ◽  
Bonnie L. Firestein
Keyword(s):  
Structural Characterization ◽  
Binding Domain ◽  
Zinc Binding ◽  
Dendrite Branching ◽  
Zinc Binding Domain

scholarly journals A general role of zinc binding domain revealed by structures of σ28-dependent transcribing complexes

2020 ◽  
Author(s):  
Wei Shi ◽  
Wei Zhou ◽  
Baoyue Zhang ◽  
Shaojia Huang ◽  
Yanan Jiang ◽  
...  
Keyword(s):  
Binding Domain ◽  
Zinc Binding ◽  
General Mechanism ◽  
General Role ◽  
Template Strand ◽  
Promoter Dna ◽  
Zinc Binding Domain

AbstractIn bacteria, σ28 is the flagella-specific sigma factor that controls the expression of flagella-related genes involving bacterial motility and chemotaxis. However, its transcriptional mechanism remains largely unclear. Here we report cryo-EM structures of σ28-dependent transcribing complexes on a complete flagella-specific DNA promoter. The structures reveal how σ28-RNA polymerase (RNAP) recognizes promoter DNA through strong interaction with −10 element but weak contact with −35 element to initiate transcription. In addition, we observed a distinct architecture in which the β′ zinc binding domain (ZBD) of RNAP stretches out from its canonical position to interact with the upstream non-template strand. Further in vitro and in vivo assays demonstrate that this interaction facilitates the isomerization of RNAP-promoter closed to open complex due to compensating the weak interaction between σ4/−35 element, and suggest that ZBD-relocation is a general mechanism employed by the σ70-family factors to enhance transcription from promoters with weak σ4/−35 element interactions.

scholarly journals Role of the linker between the zinc binding domain and the polymerization domain of the bacteriophage T7 DNA primase

2006 ◽  
Vol 20 (5) ◽  
Author(s):  
Udi Qimron ◽  
Seung‐Joo Lee ◽  
Samir M Hamdan ◽  
Charles C Richardson
Keyword(s):  
Binding Domain ◽  
Zinc Binding ◽  
Bacteriophage T7 ◽  
Dna Primase ◽  
Zinc Binding Domain

EXAFS analysis of the zinc-binding domain of boar spermatidal transition protein 2

2001 ◽  
Vol 8 (2) ◽  
pp. 993-995
Author(s):  
Takeshi Kawai ◽  
Takehisa Konishi ◽  
Takashi Fujikawa ◽  
Atushi Sekine ◽  
Lica F. Imai ◽  
...  
Keyword(s):  
Binding Domain ◽  
Zinc Binding ◽  
Exafs Analysis ◽  
Zinc Binding Domain ◽  
Transition Protein

scholarly journals Assembly of HIV-1 Vif-Cul5 E3 ubiquitin ligase through a novel zinc-binding domain-stabilized hydrophobic interface in Vif

Virology ◽  
2006 ◽  
Vol 349 (2) ◽  
pp. 290-299 ◽  
Author(s):  
Zuoxiang Xiao ◽  
Elana Ehrlich ◽  
Yunkai Yu ◽  
Kun Luo ◽  
Tao Wang ◽  
...  
Keyword(s):  
Ubiquitin Ligase ◽  
E3 Ubiquitin Ligase ◽  
Binding Domain ◽  
Zinc Binding ◽  
Zinc Binding Domain ◽  
Hiv 1 ◽  
Hydrophobic Interface

scholarly journals Novel topology of a zinc-binding domain from a protein involved in regulating early Xenopus development.

1995 ◽  
Vol 14 (23) ◽  
pp. 5947-5956 ◽  
Author(s):  
K. L. Borden ◽  
J. M. Lally ◽  
S. R. Martin ◽  
N. J. O'Reilly ◽  
L. D. Etkin ◽  
...  
Keyword(s):  
Binding Domain ◽  
Zinc Binding ◽  
Xenopus Development ◽  
Zinc Binding Domain
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